2010
ABO Blood Group, Helicobacter pylori Seropositivity, and Risk of Pancreatic Cancer: A Case–Control Study
Risch HA, Yu H, Lu L, Kidd MS. ABO Blood Group, Helicobacter pylori Seropositivity, and Risk of Pancreatic Cancer: A Case–Control Study. Journal Of The National Cancer Institute 2010, 102: 502-505. PMID: 20181960, PMCID: PMC2902822, DOI: 10.1093/jnci/djq007.Peer-Reviewed Original ResearchMeSH KeywordsABO Blood-Group SystemAdultAgedAged, 80 and overAntibodies, BacterialAntigens, BacterialBacterial ProteinsCase-Control StudiesConfounding Factors, EpidemiologicConnecticutEnzyme-Linked Immunosorbent AssayFemaleHelicobacter InfectionsHelicobacter pyloriHumansIncidenceMaleMiddle AgedOdds RatioPancreatic NeoplasmsConceptsNon-O blood typeH pylori seropositivityCase-control studyPancreatic cancerPylori seropositivityABO blood groupEnzyme-linked immunosorbent assayBlood typeBlood groupPopulation-based case-control studyNon-O blood groupControl subjects frequencyH pylori colonizationVirulence protein CagAHelicobacter pylori seropositivityPancreatic cancer riskO blood typeRandom digit dialingCagA seropositivityCase patientsH pyloriControl subjectsRisk factorsPylori colonizationCancer risk
2009
Genome-wide association study identifies variants in the ABO locus associated with susceptibility to pancreatic cancer
Amundadottir L, Kraft P, Stolzenberg-Solomon RZ, Fuchs CS, Petersen GM, Arslan AA, Bueno-de-Mesquita HB, Gross M, Helzlsouer K, Jacobs EJ, LaCroix A, Zheng W, Albanes D, Bamlet W, Berg CD, Berrino F, Bingham S, Buring JE, Bracci PM, Canzian F, Clavel-Chapelon F, Clipp S, Cotterchio M, de Andrade M, Duell EJ, Fox Jr J, Gallinger S, Gaziano JM, Giovannucci EL, Goggins M, González CA, Hallmans G, Hankinson SE, Hassan M, Holly EA, Hunter DJ, Hutchinson A, Jackson R, Jacobs KB, Jenab M, Kaaks R, Klein AP, Kooperberg C, Kurtz RC, Li D, Lynch SM, Mandelson M, McWilliams RR, Mendelsohn JB, Michaud DS, Olson SH, Overvad K, Patel AV, Peeters PH, Rajkovic A, Riboli E, Risch HA, Shu XO, Thomas G, Tobias GS, Trichopoulos D, Van Den Eeden SK, Virtamo J, Wactawski-Wende J, Wolpin BM, Yu H, Yu K, Zeleniuch-Jacquotte A, Chanock SJ, Hartge P, Hoover RN. Genome-wide association study identifies variants in the ABO locus associated with susceptibility to pancreatic cancer. Nature Genetics 2009, 41: 986-990. PMID: 19648918, PMCID: PMC2839871, DOI: 10.1038/ng.429.Peer-Reviewed Original ResearchMeSH KeywordsABO Blood-Group SystemAllelesCase-Control StudiesChromosomes, Human, Pair 9Cohort StudiesFemaleGene FrequencyGenetic Predisposition to DiseaseGenetic VariationGenome-Wide Association StudyGenotypeHaplotypesHumansIntronsLinkage DisequilibriumLogistic ModelsMaleOdds RatioPancreatic NeoplasmsPolymorphism, Single NucleotideProspective StudiesRisk FactorsUnited States
2008
Insulin, Insulin-Like Growth Factor-I, and Risk of Breast Cancer in Postmenopausal Women
Gunter MJ, Hoover DR, Yu H, Wassertheil-Smoller S, Rohan TE, Manson JE, Li J, Ho GY, Xue X, Anderson GL, Kaplan RC, Harris TG, Howard BV, Wylie-Rosett J, Burk RD, Strickler HD. Insulin, Insulin-Like Growth Factor-I, and Risk of Breast Cancer in Postmenopausal Women. Journal Of The National Cancer Institute 2008, 101: 48-60. PMID: 19116382, PMCID: PMC2639294, DOI: 10.1093/jnci/djn415.Peer-Reviewed Original ResearchMeSH KeywordsAge FactorsAgedBiomarkers, TumorBlood GlucoseBody Mass IndexBreast NeoplasmsCase-Control StudiesEstradiolEstrogen Replacement TherapyFemaleHumansHyperinsulinismInsulinInsulin-Like Growth Factor Binding Protein 3Insulin-Like Growth Factor IMiddle AgedMultivariate AnalysisObesityOdds RatioPostmenopauseProportional Hazards ModelsProspective StudiesRisk AssessmentRisk FactorsStatistics, NonparametricConceptsInsulin-like growth factorLevels of insulinBreast cancerInsulin levelsRisk factorsPostmenopausal womenGrowth factorMultiple breast cancer risk factorsMultivariable Cox proportional hazards modelsWomen's Health Initiative Observational StudyBreast cancer case subjectsBreast cancer risk factorsCox proportional hazards modelHormone therapy useIncident breast cancerIndependent risk factorPostmenopausal breast cancerCancer risk factorsCase-cohort studyProportional hazards modelTotal IGFNondiabetic womenBaseline characteristicsFree IGFProspective cohort
2004
Insulin‐like growth factor‐I gene polymorphism and breast cancer risk in Chinese women
Wen W, Gao Y, Shu X, Yu H, Cai Q, Smith J, Zheng W. Insulin‐like growth factor‐I gene polymorphism and breast cancer risk in Chinese women. International Journal Of Cancer 2004, 113: 307-311. PMID: 15386404, DOI: 10.1002/ijc.20571.Peer-Reviewed Original ResearchConceptsBreast cancer riskBreast cancerPremenopausal womenCancer riskPopulation-based case-control studyAge frequency-matched controlsChinese womenIncident breast cancer casesPlasma IGF-I levelsInsulin-like growth factorIGF-I levelsFrequency-matched controlsCase-control studyBreast cancer casesAssociation of IGFDose-response mannerMeta-analysis resultsBreast cancer susceptibilityIGF-I geneSignificant genetic factorInsulin-like growth factor-I gene polymorphismPlasma IGFCancer casesGeneral populationGene polymorphismsReports: Insulin-Like Growth Factor-I, Soy Protein Intake, and Breast Cancer Risk
Sanderson M, Shu X, Yu H, Dai Q, Malin A, Gao Y, Zheng W. Reports: Insulin-Like Growth Factor-I, Soy Protein Intake, and Breast Cancer Risk. Nutrition And Cancer 2004, 50: 8-15. PMID: 15572292, DOI: 10.1207/s15327914nc5001_2.Peer-Reviewed Original ResearchConceptsIGF-I levelsShanghai Breast Cancer StudyIGFBP-3 levelsSoy protein intakeBreast cancer riskCancer riskProtein intakeBreast cancerInsulin-like growth factor-binding protein-3 levelsPopulation-based case-control studyIncident breast cancer casesPremenopausal breast cancer riskPopulation-based cancer registriesBreast cancer cell growthInsulin-like growth factorPremenopausal breast cancerProtein-3 levelsEffects of IGFCase-control studyBreast cancer casesInsulin-like growthCancer cell growthBreast Cancer StudyPostmenopausal womenCancer RegistryIGF‐I and breast cancer: A meta‐analysis
Shi R, Yu H, McLarty J, Glass J. IGF‐I and breast cancer: A meta‐analysis. International Journal Of Cancer 2004, 111: 418-423. PMID: 15221971, DOI: 10.1002/ijc.20233.Peer-Reviewed Original ResearchConceptsHedges's standardized mean differenceIGFBP-3 levelsLevels of IGFIGF-binding proteinsBreast cancer riskStandardized mean differencePremenopausal womenBreast cancerIGFBP-3Cancer riskBreast cancer patientsEffects of IGFPostmenopausal womenPostmenopausal groupPremenopausal groupHigher IGFCancer patientsClinical studiesEpidemiologic studiesParacrine mechanismsIGFOverall associationMean differenceCancerWomenGenetic polymorphisms in the IGFBP3 gene: association with breast cancer risk and blood IGFBP-3 protein levels among Chinese women.
Ren Z, Cai Q, Shu X, Cai H, Li C, Yu H, Gao Y, Zheng W. Genetic polymorphisms in the IGFBP3 gene: association with breast cancer risk and blood IGFBP-3 protein levels among Chinese women. Cancer Epidemiology Biomarkers & Prevention 2004, 13: 1290-5. PMID: 15298948, DOI: 10.1158/1055-9965.1290.13.8.Peer-Reviewed Original ResearchMeSH KeywordsAdultAge DistributionBase SequenceBiomarkers, TumorBreast NeoplasmsCase-Control StudiesChinaConfidence IntervalsFemaleGenetic Predisposition to DiseaseHumansIncidenceInsulin-Like Growth Factor Binding Protein 3Insulin-Like Growth Factor Binding ProteinsMiddle AgedMolecular Sequence DataOdds RatioPolymerase Chain ReactionPolymorphism, GeneticPopulation SurveillanceReference ValuesRisk AssessmentConceptsInsulin-like growth factorIGFBP-3 protein levelsBreast cancer riskBreast cancerVariant allelesIGFBP3 polymorphismsIGFBP-3IGFBP3 geneCancer riskElevated riskRisk genotypesActions of IGFsIncident breast cancer patientsChinese womenIGFBP-3 levelsIGF binding proteinBreast cancer patientsGenetic polymorphismsIGFBP-3 proteinProtein levelsCase-control studyDose-response mannerCancer patientsOdds ratioPolymorphism A
2001
Insulin-like growth factor-I and prostate cancer: a meta-analysis
Shi R, Berkel H, Yu H. Insulin-like growth factor-I and prostate cancer: a meta-analysis. British Journal Of Cancer 2001, 85: 991-996. PMID: 11592771, PMCID: PMC2375097, DOI: 10.1054/bjoc.2001.1961.Peer-Reviewed Original ResearchConceptsHedges's standardized mean differenceLevels of IGFProstate cancer patientsStandardized mean differenceIGFBP-3Prostate cancerHigher IGFCancer patientsInsulin-like growth factorIGF-binding proteinsEffects of IGFCase-control studyLow IGFMEDLINE searchIGFMean differenceGrowth factorCancerPatientsStandard protocolRiskLevelsFree insulin‐like growth factor‐I and breast cancer risk
Li B, Khosravi M, Berkel H, Diamandi A, Dayton M, Smith M, Yu H. Free insulin‐like growth factor‐I and breast cancer risk. International Journal Of Cancer 2001, 91: 736-739. PMID: 11267989, DOI: 10.1002/1097-0215(200002)9999:9999<::aid-ijc1111>3.0.co;2-#.Peer-Reviewed Original ResearchConceptsIGF-I receptorInsulin-like growth factorFree IGFIGFBP-3Action of IGFBreast cancer patientsTotal IGFBreast cancer riskBreast cancerIGF-IICancer patientsPlasma levelsCancer riskFree insulin-like growth factorRace-matched healthy controlsFree IGF-I levelsConditional logistic regression analysisGrowth factorIGF-I levelsIGF binding proteinBinding of IGFHigher plasma levelsLogistic regression analysisHigher plasma IGFAnti-apoptotic effects
2000
Joint effect of insulin-like growth factors and mutagen sensitivity in lung cancer risk
Wu X, Yu H, Amos C, Hong W, Spitz M. Joint effect of insulin-like growth factors and mutagen sensitivity in lung cancer risk. Growth Hormone & IGF Research 2000, 10: s26-s27. PMID: 10984281, DOI: 10.1016/s1096-6374(00)90012-1.Peer-Reviewed Original Research
1999
Plasma Levels of Insulin-Like Growth Factor-I and Lung Cancer Risk: a Case-Control Analysis
Yu H, Spitz M, Mistry J, Gu J, Hong W, Wu X. Plasma Levels of Insulin-Like Growth Factor-I and Lung Cancer Risk: a Case-Control Analysis. Journal Of The National Cancer Institute 1999, 91: 151-156. PMID: 9923856, DOI: 10.1093/jnci/91.2.151.Peer-Reviewed Original ResearchConceptsInsulin-like growth factorLung cancer riskHigher plasma levelsPlasma levelsIGFBP-3Lung cancerControl subjectsIGF-IICancer riskOdds ratioLevels of IGFIGFBP-3 plasma levelsGrowth factorIGFBP-3 levelsPlasma IGFBP-3Primary lung cancerIGF-binding proteinsCase-control studyLung cancer developmentCase-control analysisEnzyme-linked immunosorbentPossible causal roleIGF variablesCase patientsConsecutive patients