2013
Elucidating the Landscape of Aberrant DNA Methylation in Hepatocellular Carcinoma
Song M, Tiirikainen M, Kwee S, Okimoto G, Yu H, Wong L. Elucidating the Landscape of Aberrant DNA Methylation in Hepatocellular Carcinoma. PLOS ONE 2013, 8: e55761. PMID: 23437062, PMCID: PMC3577824, DOI: 10.1371/journal.pone.0055761.Peer-Reviewed Original ResearchConceptsDifferentially Methylated RegionsPromoter CpG islandsCpG islandsDNA methylationDifferential methylationMethylation changesGenome-wide methylation profilingDM locusGenome-wide levelDifferential methylation patternsAberrant DNA methylationPotential biological functionsSignificant differential methylationGene bodiesIllumina HumanMethylation450 BeadChipGenomic regionsIntergenic regionMethylated regionsMethylation patternsCellular developmentEpigenetic changesGene promoterGene listsMethylation profilingBiological functions
2011
Relationship of folate, vitamin B12 and methylation of insulin-like growth factor-II in maternal and cord blood
Ba Y, Yu H, Liu F, Geng X, Zhu C, Zhu Q, Zheng T, Ma S, Wang G, Li Z, Zhang Y. Relationship of folate, vitamin B12 and methylation of insulin-like growth factor-II in maternal and cord blood. European Journal Of Clinical Nutrition 2011, 65: 480-485. PMID: 21245875, PMCID: PMC3071883, DOI: 10.1038/ejcn.2010.294.Peer-Reviewed Original ResearchConceptsCord bloodMaternal bloodVitamin B12Serum levelsMother's bloodWeight gainMother's weight gainRelationship of folateInsulin-like growth factor IISerum folate levelsCross-sectional studyFetal origins hypothesisLevels of folateGrowth factor IIMultivariate linear regression modelPassive smokingInsulin-like growth factor 2 geneBreast cancerFolate levelsIGF2 P3Growth factor 2 geneFactor 2 genePercentage of methylationFactor IIBlood
2007
IGF-I in epithelial ovarian cancer and its role in disease progression
Brokaw J, Katsaros D, Wiley A, Lu L, Su D, Sochirca O, de la Longrais IA, Mayne S, Risch H, Yu H. IGF-I in epithelial ovarian cancer and its role in disease progression. Growth Factors 2007, 25: 346-354. PMID: 18236213, DOI: 10.1080/08977190701838402.Peer-Reviewed Original ResearchConceptsIGF-I transcriptsDisease progressionOvarian cancerTumor progressionEpithelial ovarian cancer patientsIGF-I mRNA expressionInsulin-like growth factorParacrine/autocrine regulationIGF-I activityEpithelial ovarian cancerIGF-I actionOvarian cancer patientsFresh tumor samplesIGF-I expressionIGF-I mRNAOvarian cancer progressionEnzyme-linked immunosorbentParacrine/autocrineTotal IGFFree IGFClinicopathologic featuresCA polymorphismCancer patientsReal-time PCRElevated risk
2004
Insulin‐like growth factor‐I gene polymorphism and breast cancer risk in Chinese women
Wen W, Gao Y, Shu X, Yu H, Cai Q, Smith J, Zheng W. Insulin‐like growth factor‐I gene polymorphism and breast cancer risk in Chinese women. International Journal Of Cancer 2004, 113: 307-311. PMID: 15386404, DOI: 10.1002/ijc.20571.Peer-Reviewed Original ResearchConceptsBreast cancer riskBreast cancerPremenopausal womenCancer riskPopulation-based case-control studyAge frequency-matched controlsChinese womenIncident breast cancer casesPlasma IGF-I levelsInsulin-like growth factorIGF-I levelsFrequency-matched controlsCase-control studyBreast cancer casesAssociation of IGFDose-response mannerMeta-analysis resultsBreast cancer susceptibilityIGF-I geneSignificant genetic factorInsulin-like growth factor-I gene polymorphismPlasma IGFCancer casesGeneral populationGene polymorphismsMethylation of tumor suppressor gene p16 and prognosis of epithelial ovarian cancer
Katsaros D, Cho W, Singal R, Fracchioli S, de la Longrais I, Arisio R, Massobrio M, Smith M, Zheng W, Glass J, Yu H. Methylation of tumor suppressor gene p16 and prognosis of epithelial ovarian cancer. Gynecologic Oncology 2004, 94: 685-692. PMID: 15350359, DOI: 10.1016/j.ygyno.2004.06.018.Peer-Reviewed Original ResearchMeSH KeywordsAdultAgedAged, 80 and overDisease ProgressionDisease-Free SurvivalDNA MethylationFemaleGenes, p16HumansMiddle AgedOvarian NeoplasmsPrognosisPromoter Regions, GeneticConceptsEpithelial ovarian cancerOvarian cancer prognosisOvarian cancerP16 methylationMethylation-specific PCRCancer prognosisPrimary epithelial ovarian cancerResidual tumor sizePromoter methylationRegression survival analysisOvarian cancer progressionFresh frozen tumor tissueP16 promoter methylationFrozen tumor tissueAdvanced diseaseNegative patientsOverall survivalPatient agePositive patientsPathological variablesTumor sizeDisease stageHistological gradeAggressive tumorsDisease progression