2008
Insulin, Insulin-Like Growth Factor-I, and Risk of Breast Cancer in Postmenopausal Women
Gunter MJ, Hoover DR, Yu H, Wassertheil-Smoller S, Rohan TE, Manson JE, Li J, Ho GY, Xue X, Anderson GL, Kaplan RC, Harris TG, Howard BV, Wylie-Rosett J, Burk RD, Strickler HD. Insulin, Insulin-Like Growth Factor-I, and Risk of Breast Cancer in Postmenopausal Women. Journal Of The National Cancer Institute 2008, 101: 48-60. PMID: 19116382, PMCID: PMC2639294, DOI: 10.1093/jnci/djn415.Peer-Reviewed Original ResearchMeSH KeywordsAge FactorsAgedBiomarkers, TumorBlood GlucoseBody Mass IndexBreast NeoplasmsCase-Control StudiesEstradiolEstrogen Replacement TherapyFemaleHumansHyperinsulinismInsulinInsulin-Like Growth Factor Binding Protein 3Insulin-Like Growth Factor IMiddle AgedMultivariate AnalysisObesityOdds RatioPostmenopauseProportional Hazards ModelsProspective StudiesRisk AssessmentRisk FactorsStatistics, NonparametricConceptsInsulin-like growth factorLevels of insulinBreast cancerInsulin levelsRisk factorsPostmenopausal womenGrowth factorMultiple breast cancer risk factorsMultivariable Cox proportional hazards modelsWomen's Health Initiative Observational StudyBreast cancer case subjectsBreast cancer risk factorsCox proportional hazards modelHormone therapy useIncident breast cancerIndependent risk factorPostmenopausal breast cancerCancer risk factorsCase-cohort studyProportional hazards modelTotal IGFNondiabetic womenBaseline characteristicsFree IGFProspective cohortA Prospective Evaluation of Insulin and Insulin-like Growth Factor-I as Risk Factors for Endometrial Cancer
Gunter M, Hoover D, Yu H, Wassertheil-Smoller S, Manson J, Li J, Harris T, Rohan T, Xue X, Ho G, Einstein M, Kaplan R, Burk R, Wylie-Rosett J, Pollak M, Anderson G, Howard B, Strickler H. A Prospective Evaluation of Insulin and Insulin-like Growth Factor-I as Risk Factors for Endometrial Cancer. Cancer Epidemiology Biomarkers & Prevention 2008, 17: 921-929. PMID: 18398032, PMCID: PMC3090086, DOI: 10.1158/1055-9965.epi-07-2686.Peer-Reviewed Original ResearchMeSH KeywordsAgedBody Mass IndexCarcinoma, EndometrioidEndometrial NeoplasmsEstradiolFemaleHumansHypoglycemic AgentsInsulinInsulin-Like Growth Factor Binding Protein 1Insulin-Like Growth Factor Binding Protein 3Middle AgedMulticenter Studies as TopicObesityProportional Hazards ModelsProspective StudiesRisk FactorsConceptsInsulin-like growth factorEndometrial cancerEndometrioid adenocarcinomaRisk factorsFree IGFObese womenEstrogen levelsWomen's Health Initiative Observational StudyFree IGF-I levelsIGF-binding protein-3Growth factorBaseline serum specimensIncident endometrial cancerHormone therapy useIGF-I levelsMain histologic typesCase-cohort studyMajor risk factorHigh estrogen levelsTotal IGFPostmenopausal womenHormone therapyProspective cohortRandom subcohortTherapy useInsulin, Insulin-like Growth Factor-I, Endogenous Estradiol, and Risk of Colorectal Cancer in Postmenopausal Women
Gunter MJ, Hoover DR, Yu H, Wassertheil-Smoller S, Rohan TE, Manson JE, Howard BV, Wylie-Rosett J, Anderson GL, Ho GY, Kaplan RC, Li J, Xue X, Harris TG, Burk RD, Strickler HD. Insulin, Insulin-like Growth Factor-I, Endogenous Estradiol, and Risk of Colorectal Cancer in Postmenopausal Women. Cancer Research 2008, 68: 329-337. PMID: 18172327, PMCID: PMC4225702, DOI: 10.1158/0008-5472.can-07-2946.Peer-Reviewed Original ResearchConceptsInsulin-like growth factorFree IGFColorectal cancerPostmenopausal womenEndogenous estradiolWaist circumferenceWomen's Health Initiative Observational StudyIncident colorectal cancer casesGrowth factorBaseline serum specimensColorectal cancer incidenceColorectal cancer casesEndogenous estradiol levelsColorectal Cancer StudyStrong mitogenic effectIndependent biological pathwaysTotal IGFObese patientsProspective cohortRandom subcohortNondiabetic subjectsEstradiol levelsRisk factorsCancer incidenceExtreme quartiles
2006
Specimen processing time and measurement of total insulin-like growth factor-I (IGF-I), free IGF-I, and IGF binding protein-3 (IGFBP-3)
Harris T, Strickler H, Yu H, Pollak M, Monrad E, Travin M, Xue X, Rohan T, Kaplan R. Specimen processing time and measurement of total insulin-like growth factor-I (IGF-I), free IGF-I, and IGF binding protein-3 (IGFBP-3). Growth Hormone & IGF Research 2006, 16: 86-92. PMID: 16530441, DOI: 10.1016/j.ghir.2006.01.002.Peer-Reviewed Original ResearchConceptsFree IGF-I levelsIGF-I levelsInsulin-like growth factorTotal IGFIGFBP-3 levelsFree IGFIGFBP-3Blood specimensBlood collectionEpidemiologic studiesTotal insulin-like growth factorSerum separation tubesGrowth factorRisk of cancerEquation linear regression modelsSerum levelsCardiovascular diseaseMajor binding proteinSerum valuesIGFCommercial assaysIGFBPSpecimen processing timeProtein 3Immunosorbent assayMethylation of the insulin‐like growth factor binding protein‐3 gene and prognosis of epithelial ovarian cancer
WILEY A, KATSAROS D, FRACCHIOLI S, YU H. Methylation of the insulin‐like growth factor binding protein‐3 gene and prognosis of epithelial ovarian cancer. International Journal Of Gynecological Cancer 2006, 16: 210-218. PMID: 16445635, DOI: 10.1111/j.1525-1438.2006.00299.x.Peer-Reviewed Original ResearchMeSH KeywordsBiomarkers, TumorBiopsy, NeedleCarcinomaCohort StudiesDNA MethylationFemaleHumansImmunohistochemistryInsulin-Like Growth Factor Binding Protein 3Multivariate AnalysisNeoplasm StagingOvarian NeoplasmsOvariectomyProbabilityPrognosisProportional Hazards ModelsRetrospective StudiesRisk FactorsSensitivity and SpecificitySurvival RateConceptsIGFBP-3 promoter methylationInsulin-like growth factorIGFBP-3Disease progressionOvarian cancerGrowth factorPromoter methylationEarly-stage ovarian cancerEpithelial ovarian cancer patientsResidual tumor sizeEarly-stage diseaseIGFBP-3 expressionEpithelial ovarian cancerOvarian cancer patientsUseful prognostic markerOvarian cancer progressionIGFBP-3 promoterMethylation-specific polymerase chain reactionIGFBP-3 genePathologic variablesTumor sizeDisease stageCancer patientsPolymerase chain reactionPrognostic markerMethylation of the insulin-like growth factor binding protein-3 gene and prognosis of epithelial ovarian cancer
Wiley A, Katsaros D, Fracchioli S, Yu H. Methylation of the insulin-like growth factor binding protein-3 gene and prognosis of epithelial ovarian cancer. International Journal Of Gynecological Cancer 2006, 16: 210. DOI: 10.1136/ijgc-00009577-200601000-00034.Peer-Reviewed Original ResearchIGFBP-3 promoter methylationInsulin-like growth factorIGFBP-3Disease progressionOvarian cancerGrowth factorPromoter methylationEarly-stage ovarian cancerEpithelial ovarian cancer patientsResidual tumor sizeEarly-stage diseaseIGFBP-3 expressionEpithelial ovarian cancerOvarian cancer patientsUseful prognostic markerOvarian cancer progressionIGFBP-3 promoterMethylation-specific polymerase chain reactionIGFBP-3 genePathologic variablesTumor sizeDisease stageCancer patientsPolymerase chain reactionPrognostic marker
2004
Evaluation of the synergistic effect of insulin resistance and insulin‐like growth factors on the risk of breast carcinoma
Malin A, Dai Q, Yu H, Shu X, Jin F, Gao Y, Zheng W. Evaluation of the synergistic effect of insulin resistance and insulin‐like growth factors on the risk of breast carcinoma. Cancer 2004, 100: 694-700. PMID: 14770423, PMCID: PMC1780270, DOI: 10.1002/cncr.20023.Peer-Reviewed Original ResearchConceptsInsulin-like growth factorBreast carcinomaC-peptideIGFBP-3Insulin resistanceIGF-1Odds ratioShanghai Breast Cancer StudyGrowth factorBreast carcinoma riskHigh blood levelsBreast carcinoma casesCase-control pairsDose-response mannerBreast Cancer StudyCurrent studyHighest quartileBlood levelsLowest quartileCarcinoma casesCarcinoma riskHigh riskHigh levelsCarcinomaSignificant twofold
2003
Relation of serum insulin-like growth factor-I (IGF-I) and IGF binding protein-3 to risk of prostate cancer (United States)
Li L, Yu H, Schumacher F, Casey G, Witte J. Relation of serum insulin-like growth factor-I (IGF-I) and IGF binding protein-3 to risk of prostate cancer (United States). Cancer Causes & Control 2003, 14: 721-726. PMID: 14674736, DOI: 10.1023/a:1026383824791.Peer-Reviewed Original ResearchConceptsIGFBP-3 molar ratioInsulin-like growth factorIGFBP-3Prostate cancerHigher IGFOdds ratioSibling-matched case-control studySerum insulin-like growth factorInsulin-like growth factor IProtein 3Growth factorIGFBP-3 associationSerum IGF levelsEffects of IGFConfidence intervalsImportant risk factorCase-control studyConditional logistic regressionGrowth factor IProstatic epithelial cellsAdvanced diseaseSerum IGFIGF levelsAggressive diseaseRisk factorsAssessment of Insulin-Like Growth Factors and Mutagen Sensitivity as Predictors of Lung Cancer Risk
Wu X, Yu H, Makan N, Spitz M. Assessment of Insulin-Like Growth Factors and Mutagen Sensitivity as Predictors of Lung Cancer Risk. Methods In Molecular Medicine 2003, 75: 279-287. PMID: 12407747, DOI: 10.1385/1-59259-324-0:279.Peer-Reviewed Original ResearchMeSH Keywords7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxideBleomycinChromatidsChromosome AberrationsEnzyme-Linked Immunosorbent AssayHumansInsulin-Like Growth Factor Binding Protein 3Insulin-Like Growth Factor IInsulin-Like Growth Factor IILung NeoplasmsLymphocytesMutagenicity TestsMutagensPredictive Value of TestsRisk FactorsConceptsInsulin-like growth factorSignal transduction pathwaysGrowth factorCell cycle progressionCell membrane receptorsTransduction pathwaysBcl proteinsMAP kinaseLung cancer cellsIGF-1 receptorCell deathMembrane receptorsS phaseAntiproliferative moleculesBinding of IGFBax proteinCell proliferationLung cancer riskImportant functionsProteinCancer cellsCyclin D1Retinoic acidTypes of peptidesMitogenic action
2002
Plasma concentrations of insulin-like growth factors among healthy adult men and postmenopausal women: associations with body composition, lifestyle, and reproductive factors.
Chang S, Wu X, Yu H, Spitz M. Plasma concentrations of insulin-like growth factors among healthy adult men and postmenopausal women: associations with body composition, lifestyle, and reproductive factors. Cancer Epidemiology Biomarkers & Prevention 2002, 11: 758-66. PMID: 12163330.Peer-Reviewed Original ResearchConceptsInsulin-like growth factorIGF BP-3 levelsBody mass indexBP-3 levelsIGF BP-3IGF-II levelsHormone replacement therapyIGF-I levelsLow physical activityIGF levelsIGF-IIPhysical activityPostmenopausal womenHRT useCaloric intakeReproductive factorsLower IGF-II levelsTraditional cancer risk factorsLow IGF-I levelsPlasma insulin-like growth factorHigher body mass indexGrowth factorIGF-BP levelsPlasma IGF-IIRecent HRT useInsulin Resistance, IGFs and Energy Balance on the Risk of Breast Cancer
Malin A, Zheng W, Yu H. Insulin Resistance, IGFs and Energy Balance on the Risk of Breast Cancer. 2002 DOI: 10.21236/ada406834.Peer-Reviewed Original ResearchShanghai Breast Cancer StudyBreast cancer riskC-peptide levelsBreast cancerC-peptideCancer riskInsulin resistanceBlood C-peptide levelsPre-treatment blood samplesBreast cancer casesSubset of subjectsBreast Cancer StudyIGF bioavailabilityBlood levelsFat distributionPotential joint effectsCancer casesIGF-1Physical activityBlood samplesEpidemiological studiesBody weightIGFCancerGrowth factor
2001
Insulin-like growth factor-I and prostate cancer: a meta-analysis
Shi R, Berkel H, Yu H. Insulin-like growth factor-I and prostate cancer: a meta-analysis. British Journal Of Cancer 2001, 85: 991-996. PMID: 11592771, PMCID: PMC2375097, DOI: 10.1054/bjoc.2001.1961.Peer-Reviewed Original ResearchConceptsHedges's standardized mean differenceLevels of IGFProstate cancer patientsStandardized mean differenceIGFBP-3Prostate cancerHigher IGFCancer patientsInsulin-like growth factorIGF-binding proteinsEffects of IGFCase-control studyLow IGFMEDLINE searchIGFMean differenceGrowth factorCancerPatientsStandard protocolRiskLevelsFree insulin‐like growth factor‐I and breast cancer risk
Li B, Khosravi M, Berkel H, Diamandi A, Dayton M, Smith M, Yu H. Free insulin‐like growth factor‐I and breast cancer risk. International Journal Of Cancer 2001, 91: 736-739. PMID: 11267989, DOI: 10.1002/1097-0215(200002)9999:9999<::aid-ijc1111>3.0.co;2-#.Peer-Reviewed Original ResearchConceptsIGF-I receptorInsulin-like growth factorFree IGFIGFBP-3Action of IGFBreast cancer patientsTotal IGFBreast cancer riskBreast cancerIGF-IICancer patientsPlasma levelsCancer riskFree insulin-like growth factorRace-matched healthy controlsFree IGF-I levelsConditional logistic regression analysisGrowth factorIGF-I levelsIGF binding proteinBinding of IGFHigher plasma levelsLogistic regression analysisHigher plasma IGFAnti-apoptotic effectsIGFBP-3 in epithelial ovarian carcinoma and its association with clinico-pathological features and patient survival
Katsaros D, Yu H, Levesque M, Danese S, Genta F, Richiardi G, Fracchioli S, Khosravi M, Diamandi A, Gordini G, Diamandis E, Massobrio M. IGFBP-3 in epithelial ovarian carcinoma and its association with clinico-pathological features and patient survival. European Journal Of Cancer 2001, 37: 478-485. PMID: 11267857, DOI: 10.1016/s0959-8049(00)00423-8.Peer-Reviewed Original ResearchMeSH KeywordsAdultAgedAged, 80 and overBiomarkers, TumorDisease-Free SurvivalEnzyme-Linked Immunosorbent AssayFemaleFollow-Up StudiesHumansInsulin-Like Growth Factor Binding Protein 3Middle AgedNeoplasm ProteinsNeoplasm StagingNeoplasms, Glandular and EpithelialOvarian NeoplasmsPrognosisRisk FactorsConceptsIGFBP-3 levelsInsulin-like growth factorLower IGFBP-3 levelsEpithelial ovarian carcinomaIGFBP-3Overall survivalPatient survivalOvarian carcinomaGrowth factorUnfavourable prognostic featuresIGFBP-3 concentrationsClinico-pathological featuresEpithelial ovarian cancerPatients' overall survivalResponse of patientsOvarian cancer progressionAnti-apoptotic actionClinicopathological featuresPathological variablesPrognostic featuresResidual tumorDisease progressionOvarian cancerDisease prognosisAverage age
2000
Role of the Insulin-Like Growth Factor Family in Cancer Development and Progression
Yu H, Rohan T. Role of the Insulin-Like Growth Factor Family in Cancer Development and Progression. Journal Of The National Cancer Institute 2000, 92: 1472-1489. PMID: 10995803, DOI: 10.1093/jnci/92.18.1472.Peer-Reviewed Original ResearchMeSH KeywordsAge FactorsAlcohol DrinkingAnimalsApoptosisCase-Control StudiesCell DivisionDisease ProgressionEnergy IntakeEpidemiologic StudiesExerciseFeeding BehaviorHumansInsulin-Like Growth Factor Binding ProteinsLife StyleNeoplasmsPredictive Value of TestsPrognosisReceptors, SomatomedinSex FactorsSmokingSomatomedinsConceptsInsulin-like growth factorIGF-binding proteinsRole of IGFsEffects of IGFActions of IGFsCancer growthInsulin-like growth factor (IGF) familyGrowth factorIGF-I levelsCell proliferationIGF-I receptorHigher energy intakeGrowth factor familyIGFBP proteasesIGFBP-3Etiology of cancerMitogenic growth factorsCommon cancerCancer preventionEpidemiologic studiesHigh-energy dietCancer riskEnergy restrictionEnergy intakeCancer development
1999
Insulin‐like growth factors (IGF‐I, free IGF‐I, and IGF‐II) and insulin‐like growth factor binding proteins (IGFBP‐2, IGFBP‐3, IGFBP‐6, and ALS) in blood circulation
Yu H, Mistry J, Nicar M, Khosravi M, Diamandis A, van Doorn J, Juul A. Insulin‐like growth factors (IGF‐I, free IGF‐I, and IGF‐II) and insulin‐like growth factor binding proteins (IGFBP‐2, IGFBP‐3, IGFBP‐6, and ALS) in blood circulation. Journal Of Clinical Laboratory Analysis 1999, 13: 166-172. PMID: 10414596, PMCID: PMC6808158, DOI: 10.1002/(sici)1098-2825(1999)13:4<166::aid-jcla5>3.0.co;2-x.Peer-Reviewed Original ResearchMeSH KeywordsAdultBlood CirculationBlood ProteinsCarrier ProteinsFemaleGlycoproteinsHumansImmunoassayInsulin-Like Growth Factor Binding Protein 2Insulin-Like Growth Factor Binding Protein 3Insulin-Like Growth Factor Binding Protein 6Insulin-Like Growth Factor IInsulin-Like Growth Factor IIMaleMiddle AgedProtein BindingReceptors, SomatomedinReference ValuesSomatomedinsConceptsInsulin-like growth factorTotal insulin-like growth factorIGF-II levelsIGFBP-3IGFBP-6Growth factorLevels of IGFFree insulin-like growth factorIGFBP-2 levelsIGFBP-2Plasma levelsEpidemiological studiesReference rangeNormal populationPubertyBlood circulationAgeSerumBirthCell growthALSMalesFemalesSimilar patternGenderDo insulin-like growth factors mediate the effect of alcohol on breast cancer risk?
Yu H, Berkel J. Do insulin-like growth factors mediate the effect of alcohol on breast cancer risk? Medical Hypotheses 1999, 52: 491-496. PMID: 10459827, DOI: 10.1054/mehy.1998.0828.Peer-Reviewed Original ResearchConceptsInsulin-like growth factorBreast cancer riskBreast cancerEffects of alcoholIGF productionCancer riskElevated insulin-like growth factorHeavy drinkersGrowth factorDose-response relationshipHeavy alcohol usersAlcohol intakeEpidemiologic studiesHigh riskModerate drinkersAlcohol consumptionModerate consumptionAlcohol usersCancerDrinkersRiskModest increaseBiological mechanismsAssociationBiological roleInsulin-like growth factors and cancer.
Yu H, Berkel H. Insulin-like growth factors and cancer. Journal Of The Louisiana State Medical Society 1999, 151: 218-23. PMID: 10234899.Peer-Reviewed Original ResearchConceptsInsulin-like growth factorIGF binding proteinIGF-1Growth hormoneIGF familyInvolvement of IGFsEffects of IGFActions of IGFsGrowth factorGH replacement therapyCancer cellsIGF-1 receptorLong-term safetyAnti-proliferative effectsAging-related diseasesProgression of cancerTreatment warrantsReplacement therapyVitamin DCancer preventionIGF-1RIGF-2Epidemiologic studiesWild-type p53 proteinCancer etiologySeminal plasma biochemical markers and their association with semen analysis findings
Diamandis E, Arnett W, Foussias G, Pappas H, Ghandi S, Melegos D, Mullen B, Yu H, Srigley J, Jarvi K. Seminal plasma biochemical markers and their association with semen analysis findings. Urology 1999, 53: 596-603. PMID: 10096390, DOI: 10.1016/s0090-4295(98)00550-0.Peer-Reviewed Original ResearchConceptsVasectomy patientsProstaglandin D synthaseDifferential diagnosisBiochemical markersInsulin-like growth factorPlasma biochemical markersProstate-specific antigenSemen analysis findingsPercentage of motilityPGDS concentrationSeminal plasmaNormal morphologySperm qualitySeminal plasma correlatesPatient ageClinical valueNormal subjectsNonobstructive azoospermiaPatientsClinical groupsBiochemical parametersPlasma correlateProtein 3Immunofluorometric procedureGrowth factorPlasma Levels of Insulin-Like Growth Factor-I and Lung Cancer Risk: a Case-Control Analysis
Yu H, Spitz M, Mistry J, Gu J, Hong W, Wu X. Plasma Levels of Insulin-Like Growth Factor-I and Lung Cancer Risk: a Case-Control Analysis. Journal Of The National Cancer Institute 1999, 91: 151-156. PMID: 9923856, DOI: 10.1093/jnci/91.2.151.Peer-Reviewed Original ResearchConceptsInsulin-like growth factorLung cancer riskHigher plasma levelsPlasma levelsIGFBP-3Lung cancerControl subjectsIGF-IICancer riskOdds ratioLevels of IGFIGFBP-3 plasma levelsGrowth factorIGFBP-3 levelsPlasma IGFBP-3Primary lung cancerIGF-binding proteinsCase-control studyLung cancer developmentCase-control analysisEnzyme-linked immunosorbentPossible causal roleIGF variablesCase patientsConsecutive patients