2019
First-line ovulation induction for polycystic ovary syndrome: an individual participant data meta-analysis
Wang R, Li W, Bordewijk E, Legro R, Zhang H, Wu X, Gao J, Morin-Papunen L, Homburg R, König T, Moll E, Kar S, Huang W, Johnson N, Amer S, Vegetti W, Palomba S, Falbo A, Özmen Ü, Nazik H, Williams C, Federica G, Lord J, Sahin Y, Bhattacharya S, Norman R, van Wely M, Mol B, Network+ R, Collaboration T. First-line ovulation induction for polycystic ovary syndrome: an individual participant data meta-analysis. Human Reproduction Update 2019, 25: 717-732. PMID: 31647106, DOI: 10.1093/humupd/dmz029.Peer-Reviewed Original ResearchConceptsPolycystic ovary syndromeClinical pregnancy rateClomiphene citrateLive birth rateOvulation inductionTime-to-pregnancyAnovulatory infertilityFrequent cause of anovulatory infertilityPregnancy rateCause of anovulatory infertilityBirth rateMetformin to CCOvulation induction agentsIncreased clinical pregnancyLive birthsPrimary randomised controlled trialsClinical pregnancyRandomised controlled trialsInfertilityIndividual participant dataIPD meta-analysesWomenPositive interactionsLetrozoleAccurate assessment of outcomes
2012
Altering Hirsutism Through Ovulation Induction in Women With Polycystic Ovary Syndrome
Roth LW, Huang H, Legro RS, Diamond MP, Coutifaris C, Carson SA, Steinkampf MP, Carr BR, McGovern PG, Cataldo NA, Gosman GG, Nestler JE, Myers ER, Zhang H, Schlaff WD. Altering Hirsutism Through Ovulation Induction in Women With Polycystic Ovary Syndrome. Obstetrics And Gynecology 2012, 119: 1151-1156. PMID: 22617579, PMCID: PMC3360417, DOI: 10.1097/aog.0b013e31825618fb.Peer-Reviewed Original ResearchConceptsPolycystic ovary syndromeFerriman-Gallwey scoreClomiphene citrateOvary syndromePolycystic Ovary Syndrome IDouble-blind trialDuration of treatmentAbsence of ovulationHirsutism scoreOvulation inductionHirsute womenHirsutismSecondary analysisMetforminWomenGroup assignmentSignificant decreaseSignificant differencesTreatmentSyndromeInfertilityGreater improvementScoresPregnancyGroupEndometrial Shedding Effect on Conception and Live Birth in Women With Polycystic Ovary Syndrome
Diamond MP, Kruger M, Santoro N, Zhang H, Casson P, Schlaff W, Coutifaris C, Brzyski R, Christman G, Carr BR, McGovern PG, Cataldo NA, Steinkampf MP, Gosman GG, Nestler JE, Carson S, Myers EE, Eisenberg E, Legro RS. Endometrial Shedding Effect on Conception and Live Birth in Women With Polycystic Ovary Syndrome. Obstetrics And Gynecology 2012, 119: 902-908. PMID: 22525900, PMCID: PMC4007263, DOI: 10.1097/aog.0b013e31824da35c.Peer-Reviewed Original ResearchConceptsPolycystic ovary syndromeLive birth rateAnovulatory cyclesEndometrial sheddingClomiphene citrateOvary syndromeLive birthsEunice Kennedy Shriver National InstituteBirth rateCommon clinical practiceOccurrence of ovulationRate of conceptionAnovulatory womenOvarian stimulationOvulation inductionSpontaneous mensesProgestin withdrawalChild healthClinical practiceNetwork trialSecondary analysisOvulation rateMetforminAdverse effectsWomen
2010
Decision trees for identifying predictors of treatment effectiveness in clinical trials and its application to ovulation in a study of women with polycystic ovary syndrome
Zhang H, Legro RS, Zhang J, Zhang L, Chen X, Huang H, Casson PR, Schlaff WD, Diamond MP, Krawetz SA, Coutifaris C, Brzyski RG, Christman GM, Santoro N, Eisenberg E. Decision trees for identifying predictors of treatment effectiveness in clinical trials and its application to ovulation in a study of women with polycystic ovary syndrome. Human Reproduction 2010, 25: 2612-2621. PMID: 20716558, PMCID: PMC2939757, DOI: 10.1093/humrep/deq210.Peer-Reviewed Original ResearchMeSH KeywordsAge FactorsAndrogensAnovulationBody Mass IndexClomipheneDecision TreesDrug Therapy, CombinationFemaleFertility Agents, FemaleHumansInfertility, FemaleMetforminOrgan SizeOvulation InductionPolycystic Ovary SyndromePregnancyProinsulinRandomized Controlled Trials as TopicSex Hormone-Binding GlobulinTreatment OutcomeWaist-Hip RatioConceptsPolycystic ovary syndromeCombination of CCClomiphene citrateClinical trialsOvarian volumeOvary syndromeOvulation inductionHigher sex hormone-binding globulin levelsSex hormone-binding globulin levelsHormone-binding globulin levelsTreatment effectivenessHigher baseline insulinHip circumference ratioIncidence of ovulationBaseline physical characteristicsBaseline laboratoryOvulatory rateClinical parametersHigher waistBaseline variablesPredictive biomarkersGlobulin levelsCircumference ratioOvulatory responseTreatment outcomes