2020
Quantifying treatment selection bias effect on survival in comparative effectiveness research: findings from low-risk prostate cancer patients
Miccio JA, Talcott WJ, Jairam V, Park HS, Yu JB, Leapman MS, Johnson SB, King MT, Nguyen PL, Kann BH. Quantifying treatment selection bias effect on survival in comparative effectiveness research: findings from low-risk prostate cancer patients. Prostate Cancer And Prostatic Diseases 2020, 24: 414-422. PMID: 32989262, DOI: 10.1038/s41391-020-00291-3.Peer-Reviewed Original ResearchConceptsProstate cancer-specific survivalLow-risk prostate cancerExternal beam radiotherapyTreatment selection biasOverall survivalRadical prostatectomyProstate cancerOS differenceLow-risk prostate cancer patientsCancer-specific survivalEnd Results (SEER) databaseProstate cancer patientsClinical trial designEffectiveness researchComparative effectiveness researchPropensity-score matchingMethodsThe SurveillanceTreatment guidelinesResults databaseEntire cohortResultsA totalCancer patientsTreatment modalitiesNational registryPatient management
2019
Suicide among cancer patients
Zaorsky NG, Zhang Y, Tuanquin L, Bluethmann SM, Park HS, Chinchilli VM. Suicide among cancer patients. Nature Communications 2019, 10: 207. PMID: 30643135, PMCID: PMC6331593, DOI: 10.1038/s41467-018-08170-1.Peer-Reviewed Original ResearchConceptsStandardized mortality ratioCancer patientsHigh riskHigher standardized mortality ratiosColorectal cancer patientsEnd Results ProgramPopulation-based studyYears of agePredominant patientsLocalized diseasePerson yearsResults ProgramHodgkin's lymphomaTesticular tumorsMortality ratioRates of suicideGeneral populationPatientsCommitted suicideUnmarried malesLungSuicideRiskRepresentative dataLymphoma
2014
Prophylactic Cranial Irradiation for Patients With Locally Advanced Non–Small-Cell Lung Cancer at High Risk for Brain Metastases
Park HS, Decker RH, Wilson LD, Yu JB. Prophylactic Cranial Irradiation for Patients With Locally Advanced Non–Small-Cell Lung Cancer at High Risk for Brain Metastases. Clinical Lung Cancer 2014, 16: 292-297. PMID: 25499149, DOI: 10.1016/j.cllc.2014.11.005.Peer-Reviewed Original ResearchConceptsProphylactic cranial irradiationLA-NSCLC patientsSequential landmark analysesCell lung cancerBrain metastasesHigh riskCranial irradiationSurvival benefitLung cancerLandmark analysisEffect of PCICox proportional hazards regressionNon-PCI patientsOverall survival benefitEnd Results (SEER) databaseHigh-risk patientsStage III NSCLCGroup of patientsProportional hazards regressionLog-rank testSignificant survival differenceImmortal time biasPopulation-based analysisAdult patientsOnly patients
2012
Using the Surveillance, Epidemiology, and End Results Database to Investigate Rare Cancers, Second Malignancies, and Trends in Epidemiology, Treatment, and Outcomes
Lloyd S, Park HS, Decker RH, Wilson LD, Yu JB. Using the Surveillance, Epidemiology, and End Results Database to Investigate Rare Cancers, Second Malignancies, and Trends in Epidemiology, Treatment, and Outcomes. Current Problems In Cancer 2012, 36: 191-199. PMID: 22495057, DOI: 10.1016/j.currproblcancer.2012.03.008.Peer-Reviewed Original ResearchComparative Effectiveness Research and the Surveillance, Epidemiology, and End Results Database
Yu JB, Lloyd S, Decker RH, Wilson LD, Park HS. Comparative Effectiveness Research and the Surveillance, Epidemiology, and End Results Database. Current Problems In Cancer 2012, 36: 208-215. PMID: 22481005, DOI: 10.1016/j.currproblcancer.2012.03.010.Peer-Reviewed Original ResearchOverview of the Surveillance, Epidemiology, and End Results Database: Evolution, Data Variables, and Quality Assurance
Park HS, Lloyd S, Decker RH, Wilson LD, Yu JB. Overview of the Surveillance, Epidemiology, and End Results Database: Evolution, Data Variables, and Quality Assurance. Current Problems In Cancer 2012, 36: 183-190. PMID: 22481006, DOI: 10.1016/j.currproblcancer.2012.03.007.Peer-Reviewed Original ResearchPrediction Models, Nomograms, and Staging Validation with the Surveillance, Epidemiology, and End Results Database
Lloyd S, Park HS, Wilson LD, Decker RH, Yu JB. Prediction Models, Nomograms, and Staging Validation with the Surveillance, Epidemiology, and End Results Database. Current Problems In Cancer 2012, 36: 200-207. PMID: 22481008, DOI: 10.1016/j.currproblcancer.2012.03.009.Peer-Reviewed Original ResearchLimitations and Biases of the Surveillance, Epidemiology, and End Results Database
Park HS, Lloyd S, Decker RH, Wilson LD, Yu JB. Limitations and Biases of the Surveillance, Epidemiology, and End Results Database. Current Problems In Cancer 2012, 36: 216-224. PMID: 22481009, DOI: 10.1016/j.currproblcancer.2012.03.011.Peer-Reviewed Original ResearchImmortal Time Bias: A Frequently Unrecognized Threat to Validity in the Evaluation of Postoperative Radiotherapy
Park HS, Gross CP, Makarov DV, Yu JB. Immortal Time Bias: A Frequently Unrecognized Threat to Validity in the Evaluation of Postoperative Radiotherapy. International Journal Of Radiation Oncology • Biology • Physics 2012, 83: 1365-1373. PMID: 22342097, DOI: 10.1016/j.ijrobp.2011.10.025.Peer-Reviewed Original ResearchConceptsSequential landmark analysesPostoperative radiotherapyImmortal time biasLandmark analysisTumor typesEnd Results (SEER) databaseObservational cohort studyTime biasObservation cohortCohort studyHazard ratioProspective trialImproved survivalResults databaseConditional survivalRoutine useSurvivalApparent benefitRadiotherapyCohort
2011
Survival outcomes in atypical teratoid rhabdoid tumor for patients undergoing radiotherapy in a Surveillance, Epidemiology, and End Results analysis
Buscariollo DL, Park HS, Roberts KB, Yu JB. Survival outcomes in atypical teratoid rhabdoid tumor for patients undergoing radiotherapy in a Surveillance, Epidemiology, and End Results analysis. Cancer 2011, 118: 4212-4219. PMID: 22213196, DOI: 10.1002/cncr.27373.Peer-Reviewed Original ResearchConceptsAtypical teratoid rhabdoid tumorMedian overall survivalOverall survivalRT useLandmark analysisRhabdoid tumorRare central nervous system malignanciesNational Cancer Institute's SurveillanceCentral nervous system malignanciesCox proportional hazards modelRole of radiotherapyEnd Results (SEER) databaseEnd Results analysisSignificant survival benefitProspective clinical trialsGross total resectionPatients ages 4Nervous system malignanciesImmortal time biasProportional hazards modelLong-term survivorshipAdjuvant radiotherapyInitial radiotherapyPrimary endpointInitial management