2019
Overall survival is improved when DCIS accompanies invasive breast cancer
Kole AJ, Park HS, Johnson SB, Kelly JR, Moran MS, Patel AA. Overall survival is improved when DCIS accompanies invasive breast cancer. Scientific Reports 2019, 9: 9934. PMID: 31289308, PMCID: PMC6616329, DOI: 10.1038/s41598-019-46309-2.Peer-Reviewed Original ResearchMeSH KeywordsAdultAgedAged, 80 and overBiomarkers, TumorBreast NeoplasmsCarcinoma, Ductal, BreastCarcinoma, Intraductal, NoninfiltratingCarcinoma, LobularCombined Modality TherapyFemaleFollow-Up StudiesHumansMiddle AgedNeoplasm InvasivenessPrognosisReceptor, ErbB-2Receptors, EstrogenReceptors, ProgesteroneRetrospective StudiesSurvival RateConceptsInvasive ductal carcinomaOverall survivalDCIS componentDuctal carcinomaBreast cancerER/PR positivityPure invasive ductal carcinomasMultivariable Cox modelingReceipt of mastectomyNational Cancer DatabaseSuperior overall survivalNode-negative diseaseBetter overall survivalInvasive breast cancerFavorable clinical characteristicsTreatment-related variablesUseful prognostic factorBreast cancer patientsInvasive tumor sizeDifferent biological behaviorPR positivityClinical characteristicsNegative diseaseCox modelingPrognostic factors
2015
Growing Use of Mastectomy for Ductal Carcinoma-In Situ of the Breast Among Young Women in the United States
Rutter CE, Park HS, Killelea BK, Evans SB. Growing Use of Mastectomy for Ductal Carcinoma-In Situ of the Breast Among Young Women in the United States. Annals Of Surgical Oncology 2015, 22: 2378-2386. PMID: 25564175, DOI: 10.1245/s10434-014-4334-x.Peer-Reviewed Original ResearchConceptsContralateral prophylactic mastectomyUse of mastectomyYounger patientsHigh-risk histopathologic featuresNational Cancer Data BaseGreater medical comorbidityRate of mastectomyYounger patient ageBreast conservation therapyMultivariable logistic regressionHigh tumor gradeProportion of womenBackgroundDuctal carcinomaPreinvasive formExtensive diseaseMastectomy ratesMedical comorbiditiesPatient ageConservation therapyDuctal carcinomaHistopathologic featuresExcellent outcomesProphylactic mastectomySurgical choiceTumor grade