2021
Facility-Level Variation in Use of Locoregional Therapy for Metastatic Prostate Cancer
Buck M, Ghiraldi E, Demkowicz P, Park H, An Y, Kann B, Yu J, Sprenkle P, Kim I, Leapman M. Facility-Level Variation in Use of Locoregional Therapy for Metastatic Prostate Cancer. Urology Practice 2021, 9: 141-149. PMID: 37145694, DOI: 10.1097/upj.0000000000000290.Peer-Reviewed Original ResearchMetastatic prostate cancerLocal therapyProstate cancerLocoregional therapyFacility-level useFacility-level variationM1 prostate cancerDefinitive local therapyNational Cancer DatabaseMetastatic prostate adenocarcinomaClinical practice guidelinesMultilevel logistic regressionM1 diseasePatient factorsTherapy useUninsured statusRadical prostatectomyCancer DatabaseProstate adenocarcinomaHigh comorbidityLocal treatmentPatient levelPractice guidelinesLower oddsPatients
2020
Quantifying treatment selection bias effect on survival in comparative effectiveness research: findings from low-risk prostate cancer patients
Miccio JA, Talcott WJ, Jairam V, Park HS, Yu JB, Leapman MS, Johnson SB, King MT, Nguyen PL, Kann BH. Quantifying treatment selection bias effect on survival in comparative effectiveness research: findings from low-risk prostate cancer patients. Prostate Cancer And Prostatic Diseases 2020, 24: 414-422. PMID: 32989262, DOI: 10.1038/s41391-020-00291-3.Peer-Reviewed Original ResearchConceptsProstate cancer-specific survivalLow-risk prostate cancerExternal beam radiotherapyTreatment selection biasOverall survivalRadical prostatectomyProstate cancerOS differenceLow-risk prostate cancer patientsCancer-specific survivalEnd Results (SEER) databaseProstate cancer patientsClinical trial designEffectiveness researchComparative effectiveness researchPropensity-score matchingMethodsThe SurveillanceTreatment guidelinesResults databaseEntire cohortResultsA totalCancer patientsTreatment modalitiesNational registryPatient managementRadiation Dose to the Rectum With Definitive Radiation Therapy and Hydrogel Spacer Versus Postprostatectomy Radiation Therapy
Yang DX, Verma V, An Y, Yu JB, Sprenkle PC, Leapman MS, Park HS. Radiation Dose to the Rectum With Definitive Radiation Therapy and Hydrogel Spacer Versus Postprostatectomy Radiation Therapy. Advances In Radiation Oncology 2020, 5: 1225-1231. PMID: 33305083, PMCID: PMC7718530, DOI: 10.1016/j.adro.2020.08.015.Peer-Reviewed Original ResearchDefinitive radiation therapyPostoperative radiation therapyHydrogel spacerRadiation therapyRectal dosimetryProstate cancerGroup 1Rectal dose-volume parametersPostprostatectomy radiation therapyDose-volume parametersPostprostatectomy settingSurgical patientsPrimary managementRectal volumeDefinitive settingRadical prostatectomyRectal dosesGroup 2High riskPatientsLinear regression analysisProstatectomyMann-WhitneyTherapyCancerNational trends in the management of patients with positive surgical margins at radical prostatectomy
Ghabili K, Park HS, Yu JB, Sprenkle PC, Kim SP, Nguyen KA, Ma X, Gross CP, Leapman MS. National trends in the management of patients with positive surgical margins at radical prostatectomy. World Journal Of Urology 2020, 39: 1141-1151. PMID: 32562045, DOI: 10.1007/s00345-020-03298-6.Peer-Reviewed Original ResearchConceptsAndrogen deprivation therapyPositive surgical marginsUse of ADTPost-prostatectomy radiation therapyRadiation therapySurgical marginsRadical prostatectomyInitial courseNode-negative prostate cancerPost-operative radiation therapyMultivariable logistic regression modelNational Cancer DatabaseAdverse pathologic featuresManagement of patientsPost-operative managementLogistic regression modelsDeprivation therapySurgical cancersPrimary endpointRT useSecondary endpointsPathologic characteristicsPathologic featuresUninsured statusCancer Database
2018
National trends in the management of patients with positive surgical margins at the time of radical prostatectomy.
Ghabili K, Nguyen K, Hsiang W, Syed J, Suarez-Sarmiento A, Shuch B, Park H, Yu J, Leapman M. National trends in the management of patients with positive surgical margins at the time of radical prostatectomy. Journal Of Clinical Oncology 2018, 36: 111-111. DOI: 10.1200/jco.2018.36.6_suppl.111.Peer-Reviewed Original ResearchAdjuvant radiation therapyAndrogen deprivation therapyPositive surgical marginsNational Cancer DatabaseAdjuvant therapyRadical prostatectomyRadiation therapyProstate cancerPathologic featuresSurgical marginsAddition of ADTAdjuvant androgen deprivation therapyStudy periodPre-treatment PSAPrimary definitive treatmentMajority of patientsManagement of patientsGleason grade groupCourse of managementOptimal management approachNon-academic facilitiesLogistic regression modelsBinary logistic regression modelAnalysis menDeprivation therapy
2013
Statins and prostate cancer recurrence following radical prostatectomy or radiotherapy: a systematic review and meta-analysis
Park HS, Schoenfeld JD, Mailhot RB, Shive M, Hartman RI, Ogembo R, Mucci LA. Statins and prostate cancer recurrence following radical prostatectomy or radiotherapy: a systematic review and meta-analysis. Annals Of Oncology 2013, 24: 1427-1434. PMID: 23508824, PMCID: PMC3660083, DOI: 10.1093/annonc/mdt077.Peer-Reviewed Original ResearchConceptsRecurrence-free survivalPrimary treatment modalityLocalized prostate cancerEffect of statinsRadical prostatectomy patientsProstate cancer recurrenceHazard ratioProstatectomy patientsTreatment modalitiesRadical prostatectomyCancer recurrenceProstate cancerProstate cancer patientsOncologic outcomesDefinitive treatmentRT patientsCancer patientsEmbase databasesEligible studiesStatinsPatientsSystematic reviewRadiotherapyBeneficial effectsSystematic search