2024
Self-Assembled Fibroblast Growth Factor Nanoparticles as a Therapeutic for Oxidant-Induced Neuronal and Skin Cell Injury
Kumar S, Chu A, Theis T, Rastogi S, Costea D, Banerjee R, Das B, Yarmush M, Hsia H, Cohen R, Schachner M, Berthiaume F. Self-Assembled Fibroblast Growth Factor Nanoparticles as a Therapeutic for Oxidant-Induced Neuronal and Skin Cell Injury. ACS Applied Bio Materials 2024, 7: 5158-5170. PMID: 39038169, DOI: 10.1021/acsabm.4c00135.Peer-Reviewed Original ResearchSpinal cord injuryFGF-2Cell injuryTraumatic brain injurySkin wound healingResponses in vivoInflammatory response in vivoWound healingPressure woundsOxidant-mediated injuryFibroblast growth factor-2Growth factor 2Delayed injuryLocal inflammationNanoparticle sizeChronic skin woundsSecondary complicationsCultured neuronal cellsEndothelial cellsGrowth factorPromote neurite outgrowthCord injuryNeurological sensationsRecombinant fusion proteinNanoparticles
2016
Soluble Receptor for Advanced Glycation End Products Improves Stromal Cell–Derived Factor-1 Activity in Model Diabetic Environments
Olekson MP, Faulknor RA, Hsia HC, Schmidt AM, Berthiaume F. Soluble Receptor for Advanced Glycation End Products Improves Stromal Cell–Derived Factor-1 Activity in Model Diabetic Environments. Advances In Wound Care 2016, 5: 527-538. PMID: 28078186, PMCID: PMC5165672, DOI: 10.1089/wound.2015.0674.Peer-Reviewed Original ResearchStromal cell-derived factor-1Advanced glycation end productsPeripheral blood mononuclear cellsCellular responsesSoluble RAGEGlycation end productsBaseline ROS levelsGrowth factorExtracellular signalsExogenous SDF-1Mouse peripheral blood mononuclear cellsStem cell recruitmentHuman leukaemia 60 cellsCell-derived factor-1Exogenous growth factorsReactive oxygen species generationDiabetic murine woundsReceptor CXCR-4Blood mononuclear cellsWound healingCellular migrationCell migrationOxygen species generationMurine excisional wound modelROS levels
2014
Reversible Modulation of Myofibroblast Differentiation in Adipose-Derived Mesenchymal Stem Cells
Desai VD, Hsia HC, Schwarzbauer JE. Reversible Modulation of Myofibroblast Differentiation in Adipose-Derived Mesenchymal Stem Cells. PLOS ONE 2014, 9: e86865. PMID: 24466271, PMCID: PMC3900664, DOI: 10.1371/journal.pone.0086865.Peer-Reviewed Original ResearchMeSH KeywordsAdipose TissueBlotting, WesternCell DifferentiationCell MovementCells, CulturedExtracellular Matrix ProteinsFibroblast Growth Factor 2HumansMesenchymal Stem CellsMyofibroblastsReal-Time Polymerase Chain ReactionReverse Transcriptase Polymerase Chain ReactionRNA, MessengerSignal TransductionConceptsAdipose-derived mesenchymal stem cellsMesenchymal stem cellsExtracellular matrixERK/MAP kinaseMyofibroblastic phenotypeStem cellsRegulation of tenascinProtein type IActivation of Smad2Abundant extracellular matrixFocal adhesionsGrowth factorKinase downstreamHuman adipose-derived mesenchymal stem cellsCytoskeletal proteinsMAP kinaseStress fibersECM proteinsCell differentiationADSC differentiationDifferentiation processFibroblast-like cellsMyofibroblast differentiationNovel therapeutic strategiesRegenerative medicine