Helen Pushkarskaya, PhD
Assistant Professor in PsychiatryCards
About
Research
Publications
2026
Regional, functional and transcriptomic decoding of multidimensional brain structure alterations in obsessive-compulsive disorder
Cardoso Saraiva L, Sato J, Sebenius I, Dzinalija N, del Río-Torné C, Godinho F, Lopes A, Fernandez T, Lima M, Ramos V, Iglesio R, Abe Y, Alonso P, Ameis S, Anticevic A, Araújo A, Arnold P, Balachander S, Banaj N, Batistuzzo M, Benedetti F, Bollettini I, Bravi B, Brennan B, Buitelaar J, Castelo-Branco M, Choi S, Costa A, Dallaspezia S, Denys D, Duarte I, Echevarria M, Eng G, Fernandes A, Feusner J, Figee M, Fitzsimmons S, Fontenelle L, Grazioplene R, Ha M, Hinojosa A, Hoexter M, Huijser C, Hu H, James A, Kim M, Kwon J, Lazaro L, Lochner C, Machado-Sousa M, van Marle H, Martínez-Zalacaín I, Mataix-Cols D, Menchón J, Minuzzi L, Morgado P, Muñoz-Moreno E, Nakao T, Narayanaswamy J, Nurmi E, O’Neill J, Park I, Phillips M, Piacentini J, Picó-Pérez M, Piras F, Piras F, Postma T, Li C, Reddy J, van Rooij D, Sakai Y, de Salles Andrade J, Scheffler F, Shivakumar V, Soreni N, Stern E, van der Straten A, Thomopoulos S, Tomiyama H, Tovar-Moll F, Vecchio D, Veltman D, Venkatasubramanian G, Vriend C, Wang Z, van der Werf Y, van Wingen G, Zhao Q, Charney A, Cho Y, Shavitt R, Pushkarskaya H, Soriano-Mas C, Romero-Garcia R, Thompson P, Stein D, van den Heuvel O, Winkler A, Miguel Filho E, Pittenger C, Cappi C. Regional, functional and transcriptomic decoding of multidimensional brain structure alterations in obsessive-compulsive disorder. Nature Communications 2026 PMID: 42343090, DOI: 10.1038/s41467-026-74153-2.Peer-Reviewed Original ResearchObsessive-compulsive disorderPostmortem brain studiesBrain morphologyStudies of obsessive-compulsive disorderCortical alterationsStudies of brain morphologyDorsolateral prefrontal cortexBrain structural alterationsSubcortical shape alterationsTranscriptomic decodingPrefrontal cortexFrontoparietal networkDefault modeNeuroimaging phenotypesSensorimotor regionsMental illnessNetwork phenotypesRegional alterationsCortical curvatureExcitatory neuronsDisordersStructural phenotypesMedication useGene expression patternsSimilar alterationsCOVID Diaries, State Response to COVID Vaccination Program, December 2020 to September 2021
Moore A, Vitu B, Fraizer-Bisner F, Williams P, van der Merwe L, Gouda A, Kirilova D, Pittenger C, Pushkarskaya H. COVID Diaries, State Response to COVID Vaccination Program, December 2020 to September 2021. Scientific Data 2026, 13: 775. PMID: 41862527, PMCID: PMC13199395, DOI: 10.1038/s41597-026-06975-0.Peer-Reviewed Original ResearchThis study investigates U.S. state responses to COVID-19 vaccination programs, analyzing 5,223 public documents to assess communication strategies' impact on vaccine uptake and public trust.Threading the needle: Practical considerations for merging theory-driven computational psychiatry with data-driven analytics to enhance precision health at scale
Cheng A, Konova A, Powers A, Corlett P, Levy I, Gu X, Huys Q, Pushkarskaya H, Fineberg S, Hauser T, Chase H, Bzdok D, Harpaz-Rotem I, Babuscio T, Nichols L, Zhao Y, Sharma M, Meeker D, Xu H, Rutledge R, Pearlson G, Pittenger C, Yip S. Threading the needle: Practical considerations for merging theory-driven computational psychiatry with data-driven analytics to enhance precision health at scale. Biological Psychiatry Cognitive Neuroscience And Neuroimaging 2026 PMID: 41763489, DOI: 10.1016/j.bpsc.2026.02.009.Peer-Reviewed Reviews, Practice Guidelines, Standards, and Consensus StatementsComputational psychiatryLongitudinal trajectoriesLongitudinal dataParsing heterogeneityDiagnostic boundariesBehavioral tasksPsychiatric disordersPsychiatric diagnosticsDimensional approachLongitudinal courseSymptom trajectoriesCognitive processesDiagnostic categoriesPsychiatryIndividual changesUnderlying mechanismsClinical research methodsClinical researchHiTOPRDoCIndividualsClinical realityDisordersSymptomsTask
2025
How to Probe Dynamics of Brain Function: A Narrative Review
Pushkarskaya H, Krishnaswamy S, Pittenger C. How to Probe Dynamics of Brain Function: A Narrative Review. Biological Psychiatry 2025, 99: 874-885. PMID: 41371462, DOI: 10.1016/j.biopsych.2025.11.023.Peer-Reviewed Reviews, Practice Guidelines, Standards, and Consensus StatementsBrain functionPatterns of brain activityTheories of brain functionDynamic causal modelingComplex neural processesNeural processesPsychiatric illnessBrain processesProbe dynamicsBrain activityClinical populationsLatent trajectoriesCausal modelDynamics of brain functionBrainNarrative reviewConceptual shiftSliding-window correlationsRepresentation spaceTime-averagedTemporal complexityIllnessRecurrent neural networkTemporal ICANeural differential equationsPsychological first aid for Ukrainian civilians: protocol and reflections on a volunteer international phone-based intervention
Shraga Y, Pushkarskaya H, Sarid O. Psychological first aid for Ukrainian civilians: protocol and reflections on a volunteer international phone-based intervention. Frontiers In Digital Health 2025, 7: 1539189. PMID: 40313912, PMCID: PMC12045101, DOI: 10.3389/fdgth.2025.1539189.Peer-Reviewed Original ResearchPsychological first aidFirst aidCrisis interventionPsychological First Aid principlesPhone-based interventionsEnhancing coping strategiesEvidence-based practiceTelephone interventionInnovative careImproving future implementationReduce distressHealthcare groupsDecrease distressSense of purposeCoping strategiesSupport servicesPanic attacksCrisis settingsVolunteer biasVolunteer therapistsTherapists' reflectionsTherapistsAcute stressInterventionStandardized measures
2024
Information processing style and institutional trust as factors of COVID vaccine hesitancy
Zhao W, Russell C, Jankovsky A, Cannon T, Pittenger C, Pushkarskaya H. Information processing style and institutional trust as factors of COVID vaccine hesitancy. Scientific Reports 2024, 14: 10416. PMID: 38710827, PMCID: PMC11074285, DOI: 10.1038/s41598-024-60788-y.Peer-Reviewed Original ResearchConceptsInformation processing styleIndividual cognitive styleProcessing styleCognitive styleSelf-report measures of personalityMeasures of personalitySelf-report measuresInformation processing capacityPersonality traitsBehavioral tasksStructural equation modelingAuthoritarian submissionEquation modelingProcessing capacityStylePersonsComprehensive assessmentInformation processing capabilitiesPerceptionTrust levelProcessing capabilitiesMultifactorial natureSocio-demographic factorsClinical characteristicsTaskExternally orienting cues improve cognitive control in OCD
Bednarek L, Glover S, Ma X, Pittenger C, Pushkarskaya H. Externally orienting cues improve cognitive control in OCD. Journal Of Behavior Therapy And Experimental Psychiatry 2024, 84: 101959. PMID: 38531125, PMCID: PMC11192454, DOI: 10.1016/j.jbtep.2024.101959.Peer-Reviewed Original ResearchANT-RObsessive thoughtsWarning cueFlanker taskAlerting benefitsModels of obsessive-compulsive disorderHealthy controlsRevised attention network testObsessive-compulsive disorderAttention Network TestSelf-report measuresConflict costsCognitive controlContamination symptomsIncongruent trialsNeurocognitive tasksExecutive functionAttention taskSymptom severityNetwork TestAssociated with severityDistracted participantsCuesExternally orienting cuesFlanker
2022
Ignorance and the Brain
Smithson M, Pushkarskaya H. Ignorance and the Brain. 2022, 136-149. DOI: 10.4324/9781003100607-17.BooksNaturalistic decision makingVisual cortical areasPerceptual switchingPerceptual statesBrain activityBrain imagingCortical areasSceptical viewpointEveryday lifeDecision makingStimuliInternal informationBrainPerceptionNew informationMindDifferent interpretationsMakingBrief reviewFindingsInformationThemes
2020
Hoarding symptoms correlate with the endowment effect
Pushkarskaya H, Lenkic P, Stewart B, Tolin D, Woody S. Hoarding symptoms correlate with the endowment effect. Journal Of Behavioral And Cognitive Therapy 2020, 30: 201-210. DOI: 10.1016/j.jbct.2020.06.002.Peer-Reviewed Original ResearchExcessive acquisition of information during simple judgments in individuals with hoarding disorder
Pushkarskaya H, Stern E, Tolin D, Pittenger C. Excessive acquisition of information during simple judgments in individuals with hoarding disorder. Journal Of Obsessive-Compulsive And Related Disorders 2020, 24: 100505. DOI: 10.1016/j.jocrd.2020.100505.Peer-Reviewed Original Research
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New Haven, CT 06519