2022
Insulin increases placental triglyceride as a potential mechanism for fetal adiposity in maternal obesity
Anam AK, Cooke KM, Dratver MB, O'Bryan JV, Perley LE, Guller SM, Hwang JJ, Taylor HS, Goedeke L, Kliman HJ, Vatner DF, Flannery CA. Insulin increases placental triglyceride as a potential mechanism for fetal adiposity in maternal obesity. Molecular Metabolism 2022, 64: 101574. PMID: 35970449, PMCID: PMC9440306, DOI: 10.1016/j.molmet.2022.101574.Peer-Reviewed Original ResearchConceptsDe novo lipogenesisFetal adiposityFatty acid uptakeMaternal obesityObese womenNormal weightExcess adiposityVillous explantsInsulin receptorNewborns of mothersNormal-weight womenAcid uptakePlacental villous explantsTranscription factor SREBP-1Insulin-like growth factor 2Effect of insulinFatty acid oxidationPlacental triglyceridesPlacental responsesElevated triglyceridesMaternal hyperglycemiaWeight womenGrowth factor 2Diabetes riskPlacental metabolismTrophoblast inclusions and adverse birth outcomes
Firestein MR, Kliman HJ, Sania A, Brink LT, Holzer PH, Hofmann KM, Milano KM, Pini N, Shuffrey LC, Odendaal HJ, Fifer WP. Trophoblast inclusions and adverse birth outcomes. PLOS ONE 2022, 17: e0264733. PMID: 35231069, PMCID: PMC8887719, DOI: 10.1371/journal.pone.0264733.Peer-Reviewed Original ResearchConceptsBirth outcomesGestational ageLiveborn deliveryLive birthsFull-term live birthsChorionic villiPreterm live birthsSpecific placental pathologyFull-term birthInduction of laborAdverse birth outcomesGestational age birthweightSafe Passage StudyTrophoblast inclusionsGreater odds ratioWarrants further investigationPlacental infarctionPlacenta accretaPreterm birthPlacental pathologyVillous edemaPatient populationAlcohol exposureOdds ratioChorionic plate
2017
Estimated Placental Volume and Gestational Age
Isakov KMM, Emerson JW, Campbell KH, Galerneau F, Anders AM, Lee YK, Subramanyam P, Roberts AE, Kliman HJ. Estimated Placental Volume and Gestational Age. American Journal Of Perinatology 2017, 35: 748-757. PMID: 29281842, DOI: 10.1055/s-0037-1615285.Peer-Reviewed Original ResearchConceptsGestational ageBirth weightPlacental volumeSignificant placental pathologyWeeks gestational agePlacental pathologyUltrasound scanClinical utilityNormative curvesMicroscopic evaluationPatientsFurther validationVariety of settingsAgePercentileEPVDifferent populationsSubanalysisGestationNewbornsPlacentaPathology
2013
Utilizing Two-Dimensional Ultrasound to Develop Normative Curves for Estimated Placental Volume
Arleo EK, Troiano RN, da Silva R, Greenbaum D, Kliman HJ. Utilizing Two-Dimensional Ultrasound to Develop Normative Curves for Estimated Placental Volume. American Journal Of Perinatology 2013, 31: 683-688. PMID: 24108663, DOI: 10.1055/s-0033-1357265.Peer-Reviewed Original Research
2008
Timing of Fetal Meconium Absorption by Amnionic Macrophages
Funai E, Labowsky A, Drewes C, Kliman H. Timing of Fetal Meconium Absorption by Amnionic Macrophages. American Journal Of Perinatology 2008, 26: 093-097. PMID: 19031358, DOI: 10.1055/s-0028-1103028.Peer-Reviewed Original ResearchThe fetus, not the mother, elicits maternal immunologic rejection: lessons from discordant dizygotic twin placentas
Yusuf K, Kliman HJ. The fetus, not the mother, elicits maternal immunologic rejection: lessons from discordant dizygotic twin placentas. Journal Of Perinatal Medicine 2008, 36: 291-296. PMID: 18598117, DOI: 10.1515/jpm.2008.054.Peer-Reviewed Original ResearchConceptsChronic villitisTwin placentasT cellsMaternal immunologic rejectionMaternal immune responseNumerous T cellsBirth weight differenceMouse monoclonal antibodyWeight discordancePathologic evidenceDizygotic pregnanciesAutoimmune disordersImmunologic rejectionDichorionic placentasHistologic examinationImmune responseVillitisBacterial infectionsPlacentaMonoclonal antibodiesChorionic villiFetusesMaternal environmentWeight differencesVilli
2007
Reference Weights for Placentas Delivered before the 28th Week of Gestation
Hecht JL, Kliman HJ, Allred EN, Pflueger SM, Chang C, Doss BJ, Roberts D, Livasy CA, Bhan I, Zambrano E, Ross DW, Senagore P, Husain AN, Leviton A. Reference Weights for Placentas Delivered before the 28th Week of Gestation. Placenta 2007, 28: 987-990. PMID: 17573110, DOI: 10.1016/j.placenta.2007.04.009.Peer-Reviewed Original ResearchConceptsPost-menstrual weeksSingleton placentasBirth weightPlacenta weightBirth weight z-scoreStandard weight tableWeight z-scoreSmall birth weightWeeks of gestationFetal indicationsLive infantsGestational ageTwin placentasPoor perfusionGrowth restrictionLarger sample sizeZ-scorePlacentaWeeksFetal processesStandard weightReference weightSample sizePreeclampsiaPregnancy
1991
Fetal akinesia deformation sequence (Pena-Shokeir phenotype) associated with acquired intrauterine brain damage.
Lavi E, Montone K, Rorke L, Kliman H. Fetal akinesia deformation sequence (Pena-Shokeir phenotype) associated with acquired intrauterine brain damage. Neurology 1991, 41: 1467-8. PMID: 1891100, DOI: 10.1212/wnl.41.9.1467.Peer-Reviewed Original ResearchConceptsIntrauterine brain damageFocal cerebral infarctionTetralogy of FallotFetal akinesia deformation sequenceCocaine-using mothersPena-Shokeir phenotypeDiffuse brainstemCerebral infarctionNeuropathologic findingsPulmonary hypoplasiaIschemic damagePathologic findingsNeuronal degenerationBrain damageFacial anomaliesFallotInfarctionBrainstemTetralogyInfantsHypoplasiaCamptodactylyArthrogryposisFindingsDegeneration