Featured Publications
Trophoblast inclusions in the human placenta: Identification, characterization, quantification, and interrelations of subtypes
Kliman HJ, Firestein MR, Hofmann KM, Milano KM, Holzer PH, Brink LT, Odendaal HJ, Fifer WP. Trophoblast inclusions in the human placenta: Identification, characterization, quantification, and interrelations of subtypes. Placenta 2020, 103: 172-176. PMID: 33152642, PMCID: PMC8448462, DOI: 10.1016/j.placenta.2020.10.014.Peer-Reviewed Original Research
2022
Sex differences in early and term placenta are conserved in adult tissues
Olney K, Plaisier S, Phung T, Silasi M, Perley L, O’Bryan J, Ramirez L, Kliman H, Wilson M. Sex differences in early and term placenta are conserved in adult tissues. Biology Of Sex Differences 2022, 13: 74. PMID: 36550527, PMCID: PMC9773522, DOI: 10.1186/s13293-022-00470-y.Peer-Reviewed Original ResearchConceptsFirst trimester placentaLate first trimesterTerm placentaTrimester placentaFirst trimesterAdult tissuesGene expressionSex differencesLifelong health outcomesSex-differential gene expressionGenetic sexInnate immune responseFull-term placentaSex-linked genesInnate immune genesImmune responsePlacenta samplesHealth outcomesBrain tissuePlacentaGametologous genesDifferent timepointsSex chromosomesImmune genesSex
2017
Estimated Placental Volume and Gestational Age
Isakov KMM, Emerson JW, Campbell KH, Galerneau F, Anders AM, Lee YK, Subramanyam P, Roberts AE, Kliman HJ. Estimated Placental Volume and Gestational Age. American Journal Of Perinatology 2017, 35: 748-757. PMID: 29281842, DOI: 10.1055/s-0037-1615285.Peer-Reviewed Original ResearchConceptsGestational ageBirth weightPlacental volumeSignificant placental pathologyWeeks gestational agePlacental pathologyUltrasound scanClinical utilityNormative curvesMicroscopic evaluationPatientsFurther validationVariety of settingsAgePercentileEPVDifferent populationsSubanalysisGestationNewbornsPlacentaPathologyFirst-trimester screening for early and late preeclampsia using maternal characteristics, biomarkers, and estimated placental volume
Sonek J, Krantz D, Carmichael J, Downing C, Jessup K, Haidar Z, Ho S, Hallahan T, Kliman HJ, McKenna D. First-trimester screening for early and late preeclampsia using maternal characteristics, biomarkers, and estimated placental volume. American Journal Of Obstetrics And Gynecology 2017, 218: 126.e1-126.e13. PMID: 29097177, DOI: 10.1016/j.ajog.2017.10.024.Peer-Reviewed Original ResearchConceptsLate-onset preeclampsiaEarly-onset preeclampsiaFirst-trimester screeningWeeks' gestationMaternal characteristicsPlacental volumeUterine artery pulsatility indexArtery pulsatility indexRisk of preeclampsiaAddition of biomarkersDiagnosis of preeclampsiaDetection rateFalse positive rateMaternal biomarkersCombination of markersLate preeclampsiaPerinatal morbidityCohort studyOnset preeclampsiaArterial pressurePulsatility indexFirst trimesterMedical historySerum biomarkersMedical recordsLuteal start vaginal micronized progesterone improves pregnancy success in women with recurrent pregnancy loss
Stephenson MD, McQueen D, Winter M, Kliman HJ. Luteal start vaginal micronized progesterone improves pregnancy success in women with recurrent pregnancy loss. Fertility And Sterility 2017, 107: 684-690.e2. PMID: 28081870, DOI: 10.1016/j.fertnstert.2016.11.029.Peer-Reviewed Original ResearchConceptsPregnancy successEndometrial biopsySubsequent pregnancyLH surgePregnancy lossVaginal micronized progesteroneObservational cohort studyUnexplained pregnancy lossRecurrent pregnancy lossCohort of womenCyclin E expressionMicronized progesteronePrior pregnancyCohort studyOngoing pregnancyConcomitant findingsEndometrial glandsOdds ratioInclusion criteriaMAIN OUTCOMEPregnancyE expressionWomenCohortWeeks
2013
Utilizing Two-Dimensional Ultrasound to Develop Normative Curves for Estimated Placental Volume
Arleo EK, Troiano RN, da Silva R, Greenbaum D, Kliman HJ. Utilizing Two-Dimensional Ultrasound to Develop Normative Curves for Estimated Placental Volume. American Journal Of Perinatology 2013, 31: 683-688. PMID: 24108663, DOI: 10.1055/s-0033-1357265.Peer-Reviewed Original Research
2012
Placental Protein 13 and Decidual Zones of Necrosis: An Immunologic Diversion That May be Linked to Preeclampsia
Kliman HJ, Sammar M, Grimpel YI, Lynch SK, Milano KM, Pick E, Bejar J, Arad A, Lee JJ, Meiri H, Gonen R. Placental Protein 13 and Decidual Zones of Necrosis: An Immunologic Diversion That May be Linked to Preeclampsia. Reproductive Sciences 2012, 19: 16-30. PMID: 21989657, DOI: 10.1177/1933719111424445.Peer-Reviewed Original ResearchConceptsPlacental protein 13Spiral arteriolesImmune cellsDecidual zoneProtein 13Decidual spiral arteriolesMaternal immune cellsWeeks of gestationElective pregnancy terminationHuman placental lactogenMaternal spiral arteriolesDecidual necrosisPregnancy terminationT cellsImmunohistochemical analysisDecidual veinsIntervillus spacePlacental lactogenInvasive trophoblastApoptosis markersPP13Chorionic villiNecrosisTrophoblastArterioles
2009
Determination of Placental Weight Using Two-dimensional Sonography and Volumetric Mathematic Modeling
Azpurua H, Funai E, Coraluzzi L, Doherty L, Sasson I, Kliman M, Kliman H. Determination of Placental Weight Using Two-dimensional Sonography and Volumetric Mathematic Modeling. American Journal Of Perinatology 2009, 27: 151-155. PMID: 19653142, DOI: 10.1055/s-0029-1234034.Peer-Reviewed Original ResearchConceptsIntrauterine fetal demisePlacental weightPlacental volumePerinatal complicationsTwo-dimensional sonographyFetal growth restrictionThird trimester pregnancyHours of birthRoutine prenatal careHigh-risk casesSignificant correlationTwo-dimensional ultrasoundPlacental widthPreterm gestationFetal demisePrenatal careSubgroup analysisGrowth restrictionFetal movementsComplicationsSonographySpearman's rhoIUGRPregnancyGestation
2008
The fetus, not the mother, elicits maternal immunologic rejection: lessons from discordant dizygotic twin placentas
Yusuf K, Kliman HJ. The fetus, not the mother, elicits maternal immunologic rejection: lessons from discordant dizygotic twin placentas. Journal Of Perinatal Medicine 2008, 36: 291-296. PMID: 18598117, DOI: 10.1515/jpm.2008.054.Peer-Reviewed Original ResearchConceptsChronic villitisTwin placentasT cellsMaternal immunologic rejectionMaternal immune responseNumerous T cellsBirth weight differenceMouse monoclonal antibodyWeight discordancePathologic evidenceDizygotic pregnanciesAutoimmune disordersImmunologic rejectionDichorionic placentasHistologic examinationImmune responseVillitisBacterial infectionsPlacentaMonoclonal antibodiesChorionic villiFetusesMaternal environmentWeight differencesVilli
2006
Optimization of endometrial preparation results in a normal endometrial function test® (EFT®) and good reproductive outcome in donor ovum recipients
Kliman HJ, Honig S, Walls D, Luna M, McSweet JC, Copperman AB. Optimization of endometrial preparation results in a normal endometrial function test® (EFT®) and good reproductive outcome in donor ovum recipients. Journal Of Assisted Reproduction And Genetics 2006, 23: 299-303. PMID: 16983518, DOI: 10.1007/s10815-006-9061-1.Peer-Reviewed Original ResearchConceptsFunction testsCourse of estrogensOvum donation cyclesUnexplained infertility patientsBetter reproductive outcomesCyclin EOvum recipientsClinical pregnancyEndometrial biopsyInfertility patientsProgesterone supplementationSuch patientsEndometrial receptivityDonation cyclesSuccessful pregnancyPregnancy failureDonor oocytesLeuprolide acetateSole patientUterine preparationsImmunohistochemical stainingReproductive outcomesStimulation protocolTransfer cyclesSuccessful implantationMouse ascites Golgi mucin expression abnormalities in natural cycle endometrial biopsies predict subsequent in vitro fertilization–embryo transfer (IVF-ET) failure in patients with previous IVF-ET failures
Catalanotti JS, Spandorfer SD, Barmat LI, Rosenwaks Z, McSweet JC, Kliman HJ. Mouse ascites Golgi mucin expression abnormalities in natural cycle endometrial biopsies predict subsequent in vitro fertilization–embryo transfer (IVF-ET) failure in patients with previous IVF-ET failures. Fertility And Sterility 2006, 85: 255-258. PMID: 16412771, DOI: 10.1016/j.fertnstert.2005.06.060.Peer-Reviewed Original ResearchConceptsIVF-ET failureFertilization-embryo transfer failureIVF-ET outcomeClinical pregnancy rateRetrospective cohort studyHigh positive predictive valuePositive predictive valueCohort studyEndometrial biopsyIVF-ETEndometrial expressionPregnancy ratePredictive valueExpression abnormalitiesAbnormal miceSignificant decreaseMiceWomenTransfer failureFailureBiopsyPatientsExpressionAbnormalitiesGolgi expression
2002
Sexual Activity, Orgasm and Tampon Use Are Associated with a Decreased Risk for Endometriosis
Meaddough EL, Olive DL, Gallup P, Perlin M, Kliman HJ. Sexual Activity, Orgasm and Tampon Use Are Associated with a Decreased Risk for Endometriosis. Gynecologic And Obstetric Investigation 2002, 53: 163-169. PMID: 12053101, DOI: 10.1159/000058368.Peer-Reviewed Original Research
2000
Endometrial dating and determination of the window of implantation in healthy fertile women
Acosta A, Elberger L, Borghi M, Calamera J, Chemes H, Doncel G, Kliman H, Lema B, Lustig L, Papier S. Endometrial dating and determination of the window of implantation in healthy fertile women. Fertility And Sterility 2000, 73: 788-798. PMID: 10731542, DOI: 10.1016/s0015-0282(99)00605-6.Peer-Reviewed Original ResearchMeSH KeywordsAdultEmbryo ImplantationEndometriumEstradiolFemaleFollicle Stimulating HormoneGolgi ApparatusGrowth InhibitorsHumansImmunohistochemistryIntegrin alpha4beta1IntegrinsInterleukin-6Leukemia Inhibitory FactorLuteinizing HormoneLymphokinesMenstrual CycleMicroscopy, Electron, ScanningMucinsProspective StudiesReceptors, Interleukin-1Receptors, Interleukin-1 Type IReceptors, Lymphocyte HomingReceptors, ProgesteroneReceptors, VitronectinReference ValuesConceptsWindow of implantationLeukemia inhibitory factorLuteal phaseDay 22Day 20Endometrial datingInterleukin-1 receptor type IAssisted reproductive unitWhole luteal phaseProspective clinical studyHealthy fertile womenIL-1R tIReceptor type IMAG antibodyEndometrial biopsyFertile womenNormal womenImplantation windowP4 receptorReceptor expressionClinical studiesLH peakHealthy volunteersMAIN OUTCOMEImmunohistochemical determination
1996
Modulation of leukemia inhibitory factor gene expression and protein biosynthesis in the human fallopian tube
Keltz M, Attar E, Buradagunta S, Olive D, Kliman H, Arici A. Modulation of leukemia inhibitory factor gene expression and protein biosynthesis in the human fallopian tube. American Journal Of Obstetrics And Gynecology 1996, 175: 1611-1619. PMID: 8987949, DOI: 10.1016/s0002-9378(96)70114-x.Peer-Reviewed Original ResearchMeSH KeywordsAdultBlood Physiological PhenomenaCells, CulturedCulture MediaCytokinesEpitheliumFallopian TubesFemaleGene Expression RegulationGrowth InhibitorsGrowth SubstancesHormonesHumansInterleukin-6Leukemia Inhibitory FactorLymphokinesMiddle AgedPregnancyPregnancy, EctopicRNA, MessengerStromal CellsConceptsLeukemia inhibitory factor expressionLeukemia inhibitory factorFallopian tubeInhibitory factorStromal cellsEctopic pregnancyStromal cell culturesGrowth factorMessenger ribonucleic acidLeukemia inhibitory factor gene expressionEctopic implantationFactor expressionTubal ectopic pregnancyEpithelial cellsInterleukin-1 alphaHuman fallopian tubePlatelet-derived growth factorMessenger ribonucleic acid levelsRibonucleic acid levelsFactor gene expressionTubal mucosaMenstrual cycleTNF-alphaTumor necrosisCommon site
1995
Endosalpingiosis found at laparoscopy for chronic pelvic pain**Presented at the 50th Annual Meeting of The American Fertility Society Meeting, San Antonio, Texas, November 5 to 10, 1994.
Keltz M, Kliman H, Arici A, Olive D. Endosalpingiosis found at laparoscopy for chronic pelvic pain**Presented at the 50th Annual Meeting of The American Fertility Society Meeting, San Antonio, Texas, November 5 to 10, 1994. Fertility And Sterility 1995, 64: 482-485. PMID: 7641898, DOI: 10.1016/s0015-0282(16)57780-2.Peer-Reviewed Original ResearchConceptsChronic pelvic painPelvic pain symptomsPelvic painPain symptomsAmerican Fertility Society MeetingYale-New Haven HospitalPatient undergoing laparoscopyUndergoing laparoscopyChronic painChronic pelvicEndosalpingiosisRetrospective analysisPainPathology specimensEndometriosisLaparoscopyPatientsSymptomsSociety meetingsAnnual MeetingSurgeryPelvicHospitalSan AntonioSurgeonsA mucin-like glycoprotein identified by MAG (mouse ascites Golgi) antibodies. Menstrual cycle-dependent localization in human endometrium.
Kliman HJ, Feinberg RF, Schwartz LB, Feinman MA, Lavi E, Meaddough EL. A mucin-like glycoprotein identified by MAG (mouse ascites Golgi) antibodies. Menstrual cycle-dependent localization in human endometrium. American Journal Of Pathology 1995, 146: 166-81. PMID: 7531946, PMCID: PMC1870765.Peer-Reviewed Original ResearchConceptsMAG antibodyMucin-like glycoproteinHigh molecular weight mucin-like glycoproteinBlood groupCycle days 5Bile duct epitheliumAnti-MAG antibodiesConceptus-endometrial interactionsExpression of mucinsBlood type ABlood group AHuman endometrial glandsEndometrial biopsyPancreatic acinar cellsEndometrial glandsEndometrial surfaceIgG antibodiesImplantation windowHuman endometriumImmunohistochemical stainingGroup AGall bladderLuminal epitheliumDuct epitheliumLacrimal gland
1991
Preeclampsia, trisomy 13, and the placental bed.
Feinberg RF, Kliman HJ, Cohen AW. Preeclampsia, trisomy 13, and the placental bed. Obstetrics And Gynecology 1991, 78: 505-8. PMID: 1870809.Peer-Reviewed Original ResearchConceptsTrisomy 13Placental bedAbnormal trophoblastic invasionGrowth-retarded infantsNormal physiologic changesDevelopment of preeclampsiaMaternal uterine vasculatureFetal trisomy 13Severe preeclampsiaMultiparous womenSpiral arteriesUterine vasculatureTrophoblastic invasionPhysiologic changesTrophoblastic functionGenetic predispositionPreeclampsiaMultiparasBiopsyArteryPathophysiologyInfants