1992
Differentiation of the Trophoblast
Kliman H, Feinberg R. Differentiation of the Trophoblast. 1992, 3-25. DOI: 10.1007/978-3-642-84385-3_1.Peer-Reviewed Original ResearchOuter cell layersHuman trophoblastsTrophoblastic cell columnsDifferentiation pathwayUnique cellsDifferentiated functionsDifferentiation behaviorUndifferentiated cytotrophoblastsGestational ageIntermediate trophoblastSubsequent functionVillous syncytiotrophoblastCell columnVillous cytotrophoblastsHuman placentaTrophoblastCytotrophoblastsCell layerControl mechanismsBiologyDifferentiationPathwayBlastocystsPlacentaSyncytiotrophoblast
1987
HLA antigen expression and induction by γ-interferon in cultured human trophoblasts
Feinman M, Kliman H, Main E. HLA antigen expression and induction by γ-interferon in cultured human trophoblasts. American Journal Of Obstetrics And Gynecology 1987, 157: 1429-1434. PMID: 3122576, DOI: 10.1016/s0002-9378(87)80238-7.Peer-Reviewed Original ResearchConceptsHuman trophoblastsHLA antigen expressionHLA class I heavy chainsClass II antigensClass I HLACultured human trophoblastsHLA heavy chainsPregnancy complicationsHLA antigensClass I heavy chainsII antigensAntigen expressionHeavy chainI HLAΓ-interferonImmunocytochemical studyAntigenMonoclonal antibodiesClass ICellular stainingTime courseTrophoblastCytotrophoblastsExpressionGene expressionDifferentiaton of Human Cytotrophoblast into Syncytiotrophoblast in Culture
Kliman H, Feinman M, Strauss J. Differentiaton of Human Cytotrophoblast into Syncytiotrophoblast in Culture. Trophoblast Research 1987, 407-421. DOI: 10.1007/978-1-4757-1936-9_29.Peer-Reviewed Original ResearchHuman chorionic gonadotropinHuman placental lactogenPrevention of rejectionPatterns of hCGHuman term placentaFetal circulationMononuclear cellsProgesterone secretionChorionic gonadotropinPlacental lactogenTerm placentaHuman cytotrophoblastsImmunoglobulin transportTrophoblastImmunocytochemical localizationProtein hormonesSyncytiotrophoblastCytotrophoblastsFetusesMothersEarlier reportsMorphological changesReportSyncytial structureCells
1986
Purification, Characterization, and in vitro Differentiation of Cytotrophoblasts from Human Term Placentae*
KLIMAN H, NESTLER J, SERMASI E, SANGER J, STRAUSS J. Purification, Characterization, and in vitro Differentiation of Cytotrophoblasts from Human Term Placentae*. Endocrinology 1986, 118: 1567-1582. PMID: 3512258, DOI: 10.1210/endo-118-4-1567.Peer-Reviewed Original ResearchConceptsHuman term placentaTerm placentaImmunoperoxidase methodHCG-positive cellsOccasional single cellsPregnancy-specific beta 1Human placental lactogenPercoll gradient centrifugation stepDifferentiation of cytotrophoblastsPregnancy-specific betaFunctional syncytiotrophoblastsPlacental lactogenSyncytial groupsCultured trophoblastsHuman cytotrophoblastsOccasional cellsProgesterone synthesisSyncytial trophoblastHCGEndothelial cellsBeta 1CytotrophoblastsTrophoblastTime pointsPlacenta