2021
YAP1 nuclear efflux and transcriptional reprograming follow membrane diminution upon VSV-G-induced cell fusion
Feliciano D, Ott CM, Espinosa-Medina I, Weigel AV, Benedetti L, Milano KM, Tang Z, Lee T, Kliman HJ, Guller SM, Lippincott-Schwartz J. YAP1 nuclear efflux and transcriptional reprograming follow membrane diminution upon VSV-G-induced cell fusion. Nature Communications 2021, 12: 4502. PMID: 34301937, PMCID: PMC8302681, DOI: 10.1038/s41467-021-24708-2.Peer-Reviewed Original ResearchMeSH KeywordsAdaptor Proteins, Signal TransducingAMP-Activated Protein KinasesAnimalsBiological TransportCell FusionCell LineCell Line, TumorCell MembraneCell NucleusCells, CulturedGiant CellsHEK293 CellsHumansMembrane GlycoproteinsMiceRNA-SeqSignal TransductionTranscription FactorsTranscription, GeneticViral Envelope ProteinsYAP-Signaling ProteinsConceptsCell cycle arrestCell fusionNew cellular statesPlasma membrane surface areaRNA-seq analysisCell fusion systemTranscriptional programsNutrient stressCellular statesTranscriptional changesNuclear effluxCytoplasmic glucoseExtrinsic cuesUndifferentiated cellsGlucose transporterFused cellsMechanistic insightsMembrane surface areaNew functionsEndocytosisYAP1 inhibitionEnergetic stateSyncytiaCellsVSV
1995
First-trimester endocervical irrigation: feasibility of obtaining trophoblast cells for prenatal diagnosis.
Bahado-Singh RO, Kliman H, Feng TY, Hobbins J, Copel JA, Mahoney MJ. First-trimester endocervical irrigation: feasibility of obtaining trophoblast cells for prenatal diagnosis. Obstetrics And Gynecology 1995, 85: 461-4. PMID: 7862393, DOI: 10.1016/0029-7844(94)00416-b.Peer-Reviewed Original ResearchConceptsTrophoblast cellsPrenatal diagnosisInternal cervical osElective pregnancy terminationFirst trimester diagnosisPlacental pathologistPregnant patientsWeeks' gestationCervical osNormal salinePregnancy terminationUltrasound guidanceAdditional casesPlastic catheterDiagnosisFirst-trimester prenatal diagnosisBrief durationGestationHCG antibodySignificant percentageFurther testingCellsLight microscopyTechnical simplicityPatients
1993
Tropho-uteronectin (tun): A unique oncofetal fibronectin deposited in the extracellular matrix of the tropho-uterine junction and regulated in vitro by cultured human trophoblast cells
Feinberg R, Kliman H. Tropho-uteronectin (tun): A unique oncofetal fibronectin deposited in the extracellular matrix of the tropho-uterine junction and regulated in vitro by cultured human trophoblast cells. Placenta 1993, 14: 167-179. DOI: 10.1016/s0143-4004(05)80292-9.Peer-Reviewed Original Research
1990
Purified Human Cytotrophoblasts: Surrogates for The Blastocyst in In Vitro Models of Implantation?
Coutifaris C, Babalola G, Feinberg R, Kao L, Kliman H, Strauss J. Purified Human Cytotrophoblasts: Surrogates for The Blastocyst in In Vitro Models of Implantation? 1990, 687-695. DOI: 10.1007/978-1-4613-0645-0_74.Peer-Reviewed Original ResearchEndometrial epithelial cellsEpithelial cellsBasal laminaHuman embryo implantationEmbryo-maternal interactionsEndometrial stromaStromal invasionEpithelial destructionEmbryo implantationTrophoblastic cellsHuman cytotrophoblastsUterine epitheliumVitro modelImplantationNidationTrophoblastInterspecies differencesCells
1988
Biosynthesis and turnover of a 34‐kDa protein growth factor in human cytotrophoblasts
ROY‐CHOUDHURY S, SEN‐MAJUMDAR A, MURTHY U, MISHRA V, KLIMAN H, NESTLER J, STRAUSS J, Manjusri D. Biosynthesis and turnover of a 34‐kDa protein growth factor in human cytotrophoblasts. The FEBS Journal 1988, 172: 777-783. PMID: 3350024, DOI: 10.1111/j.1432-1033.1988.tb13957.x.Peer-Reviewed Original ResearchConceptsProtein growth factorsWestern blot analysisMolecular massPolypeptide molecular massPartial amino acid sequenceAmino acid sequenceBlot analysisGrowth factorMetabolic labeling experimentsPulse-chase experimentsCellular mRNAsVitro translationAcid sequenceReceptor binding specificityBinding specificityIntact cellsLow molecular massBiosynthesisCultured cytotrophoblastsProteinMultinuclear syncytiotrophoblastHuman placentaLabeling experimentsHuman cytotrophoblastsCells
1987
Differentiaton of Human Cytotrophoblast into Syncytiotrophoblast in Culture
Kliman H, Feinman M, Strauss J. Differentiaton of Human Cytotrophoblast into Syncytiotrophoblast in Culture. Trophoblast Research 1987, 407-421. DOI: 10.1007/978-1-4757-1936-9_29.Peer-Reviewed Original ResearchHuman chorionic gonadotropinHuman placental lactogenPrevention of rejectionPatterns of hCGHuman term placentaFetal circulationMononuclear cellsProgesterone secretionChorionic gonadotropinPlacental lactogenTerm placentaHuman cytotrophoblastsImmunoglobulin transportTrophoblastImmunocytochemical localizationProtein hormonesSyncytiotrophoblastCytotrophoblastsFetusesMothersEarlier reportsMorphological changesReportSyncytial structureCells