1998
Fetal Lung mRNA Levels of Hox Genes Are Differentially Altered by Maternal Diabetes and Butyrate in Rats
Jacobs H, Bogue C, Pinter E, Wilson C, Warshaw J, Gross I. Fetal Lung mRNA Levels of Hox Genes Are Differentially Altered by Maternal Diabetes and Butyrate in Rats. Pediatric Research 1998, 44: 99-104. PMID: 9667378, DOI: 10.1203/00006450-199807000-00016.Peer-Reviewed Original ResearchMeSH KeywordsAnimalsButyratesButyric AcidDiabetes Mellitus, ExperimentalEmbryonic and Fetal DevelopmentFemaleGene Expression Regulation, DevelopmentalGenes, HomeoboxGestational AgeHistone Deacetylase InhibitorsLungOrgan Culture TechniquesPregnancyPregnancy in DiabeticsRatsRats, Sprague-DawleyRNA, MessengerTranscription, GeneticConceptsLung developmentLung explantsSurfactant apoproteinExperimental animalsLung mRNA levelsElevated levelsEffect of diabetesFetal rat lung explantsLungs of fetusesRat lung explantsEffect of butyrateAntenatal exposureMaternal diabetesMetabolic abnormalitiesStreptozotocin treatmentLower incidenceNormal ratsDiabetesDexamethasoneLevel of expressionRatsTreatment of explantsSodium butyrateMRNA levelsAlters expression
1987
Betamethasone Increases Pulmonary Compliance in Part by Surfactant-Independent Mechanisms in Preterm Rabbits
Fiascone J, Jacobs H, Moya F, Mercurio M, Lima D. Betamethasone Increases Pulmonary Compliance in Part by Surfactant-Independent Mechanisms in Preterm Rabbits. Pediatric Research 1987, 22: 730-735. PMID: 3431959, DOI: 10.1203/00006450-198712000-00024.Peer-Reviewed Original ResearchConceptsAntenatal corticosteroidsIntratracheal surfactantPulmonary complianceDynamic complianceAlveolar surfactant contentHigher dynamic complianceAntenatal exposurePreterm rabbitsPreterm animalsSingle therapyAlveolar lavageTidal volumeCorticosteroidsFirst breathFetusesDay 25Compliance studiesVentilationRabbitsComplianceCompliance measurementsLavageGestationBetamethasoneTherapy