2022
Distinct signatures of loss of consciousness in focal impaired awareness versus tonic-clonic seizures
Juan E, Górska U, Kozma C, Papantonatos C, Bugnon T, Denis C, Kremen V, Worrell G, Struck A, Bateman L, Merricks E, Blumenfeld H, Tononi G, Schevon C, Boly M. Distinct signatures of loss of consciousness in focal impaired awareness versus tonic-clonic seizures. Brain 2022, 146: 109-123. PMID: 36383415, PMCID: PMC10582624, DOI: 10.1093/brain/awac291.Peer-Reviewed Original ResearchConceptsBilateral tonic-clonic seizuresFocal impaired awarenessTonic-clonic seizuresLoss of consciousnessSeizure onset zoneSlow wave activityIntracranial EEG activityImpaired awarenessIctal recruitmentCortical activationOnset zoneHigh-gamma activityCross-frequency couplingFocal impaired awareness seizuresNegative prognostic consequencesSleep-like activityEEG activityCortical firing ratesParieto-occipital cortexPosterior brain regionsMulti-unit activityAwareness seizuresClinical outcomesPrognostic consequencesClinical signs
2019
Up and Down States of Cortical Neurons in Focal Limbic Seizures
Yue Z, Freedman IG, Vincent P, Andrews JP, Micek C, Aksen M, Martin R, Zuckerman D, Perrenoud Q, Neske GT, Sieu LA, Bo X, Cardin JA, Blumenfeld H. Up and Down States of Cortical Neurons in Focal Limbic Seizures. Cerebral Cortex 2019, 30: 3074-3086. PMID: 31800015, PMCID: PMC7197089, DOI: 10.1093/cercor/bhz295.Peer-Reviewed Original ResearchConceptsFocal limbic seizuresDeep anesthesiaLimbic seizuresCortical neuronsVivo whole-cell recordingsDepressed cortical functionInput resistanceNeocortical slow wavesSubcortical arousal systemsLoss of consciousnessWhole-cell recordingsCortical-subcortical networksSeizure propagationMembrane potentialRat modelCortical functionTemporal lobeSeizuresCortical arousalExtracellular recordingsElectrophysiological propertiesCortical electrophysiologyFiring rateAnesthesiaArousal system
2015
Decreased Subcortical Cholinergic Arousal in Focal Seizures
Motelow JE, Li W, Zhan Q, Mishra AM, Sachdev RN, Liu G, Gummadavelli A, Zayyad Z, Lee HS, Chu V, Andrews JP, Englot DJ, Herman P, Sanganahalli BG, Hyder F, Blumenfeld H. Decreased Subcortical Cholinergic Arousal in Focal Seizures. Neuron 2015, 85: 561-572. PMID: 25654258, PMCID: PMC4319118, DOI: 10.1016/j.neuron.2014.12.058.Peer-Reviewed Original ResearchConceptsTemporal lobe seizuresFocal temporal lobe seizuresReduced cholinergic neurotransmissionBilateral temporal lobesLoss of consciousnessPedunculopontine tegmental nucleusQuality of lifeBrainstem arousal systemsFunctional magnetic resonanceSeizure spreadCholinergic neuronsImpaired consciousnessFocal seizuresBasal forebrainAnterior hypothalamusCholinergic neurotransmissionTegmental nucleusLateral septumCortical functionRodent modelsTemporal lobeSubcortical regionsSeizuresImpair consciousnessSubcortical arousal
2013
Temporal Lobe Seizures
Furman M, Blumenfeld H. Temporal Lobe Seizures. 2013, 51-62. DOI: 10.1007/978-3-642-37580-4_4.Peer-Reviewed Original ResearchTemporal lobe seizuresTemporal epilepsyTemporal lobeFocal temporal lobe seizuresNetwork inhibition hypothesisSlow electroencephalogram activityLoss of consciousnessParietal association cortexImpaired consciousnessCortical dysfunctionSide effectsAnimal modelsNovel treatmentsAssociation cortexDeep anesthesiaAwake stateHuman patientsElectrophysiological techniquesMemory lossSeizuresElectroencephalogram (EEG) activityElectrophysiological dataEpilepsyCortexLobe
2011
The Default Mode Network and Altered Consciousness in Epilepsy
Danielson N, Guo J, Blumenfeld H. The Default Mode Network and Altered Consciousness in Epilepsy. Behavioural Neurology 2011, 24: 55-65. DOI: 10.1155/2011/912720.Peer-Reviewed Original ResearchLoss of consciousnessDefault mode networkDefault mode network activitySeizure typesMode networkArousal systemNetwork inhibition hypothesisTypes of seizuresSubcortical arousal systemsCertain cortical regionsPrecuneus/posterior cingulateLateral parietal cortexNetwork activityActive inhibitionAltered consciousnessAbsence seizuresCortical deactivationCortical areasEpileptic seizuresAwake statePosterior cingulateParietal cortexSeizuresCortical regionsElectrophysiological modalities