2009
The Yb protein defines a novel organelle and regulates male germline stem cell self-renewal in Drosophila melanogaster
Szakmary A, Reedy M, Qi H, Lin H. The Yb protein defines a novel organelle and regulates male germline stem cell self-renewal in Drosophila melanogaster. Journal Of Cell Biology 2009, 185: 613-627. PMID: 19433453, PMCID: PMC2711570, DOI: 10.1083/jcb.200903034.Peer-Reviewed Original ResearchMeSH KeywordsAnimalsCell DivisionDrosophila melanogasterDrosophila ProteinsFemaleGerm CellsMaleOrganellesOvaryStem CellsTestisConceptsYB proteinsNiche cellsYb bodiesElectron-dense spheresDrosophila melanogasterGermline stem cell maintenanceMale germline stem cellsGermline stem cellsStem cell maintenanceStem cellsC-terminal regionSomatic stem cellsN-terminal regionD. melanogasterNovel organellePiwi expressionGermline cellsDouble mutantCell maintenanceNovel lociSomatic cellsCytoplasmic spotsMelanogasterCytoplasmic structuresGermline loss
2008
Cell biology of stem cells: an enigma of asymmetry and self-renewal
Lin H. Cell biology of stem cells: an enigma of asymmetry and self-renewal. Journal Of Cell Biology 2008, 180: 257-260. PMID: 18227277, PMCID: PMC2213586, DOI: 10.1083/jcb.200712159.Peer-Reviewed Original ResearchConceptsCell biologyStem cellsIntrinsic cell polarityDrosophila melanogaster neuroblastsGermline stem cellsStem cell divisionStem cell systemCell cycle regulatorsSkin stem cellsNiche signalingCell polarityAsymmetric divisionDaughter cellsCell divisionCycle regulatorsStem cell researchBiologyCell researchCell systemCellsCrucial roleTherapeutic applicationsDivisionDiverse typesCentrosomes
2007
Precancerous Stem Cells Have the Potential for both Benign and Malignant Differentiation
Chen L, Shen R, Ye Y, Pu XA, Liu X, Duan W, Wen J, Zimmerer J, Wang Y, Liu Y, Lasky LC, Heerema NA, Perrotti D, Ozato K, Kuramochi-Miyagawa S, Nakano T, Yates AJ, Carson WE, Lin H, Barsky SH, Gao JX. Precancerous Stem Cells Have the Potential for both Benign and Malignant Differentiation. PLOS ONE 2007, 2: e293. PMID: 17356702, PMCID: PMC1808425, DOI: 10.1371/journal.pone.0000293.Peer-Reviewed Original ResearchConceptsCancer stem cellsMalignant differentiationPrecancerous stem cellsStem cellsImmunocompetent miceImmunodeficient miceSolid cancersSolid tumorsTherapy of cancerC-kitNovel targetCancerEarly detectionCancer cellsSca-1Lineage markersTissue cellsMicePCSCsCellsSingle cloneDifferentiationTherapyTumorsPrevention
2004
Germline stem cells in the Drosophila ovary descend from pole cells in the anterior region of the embryonic gonad
Asaoka M, Lin H. Germline stem cells in the Drosophila ovary descend from pole cells in the anterior region of the embryonic gonad. Development 2004, 131: 5079-5089. PMID: 15459101, DOI: 10.1242/dev.01391.Peer-Reviewed Original ResearchConceptsGermline stem cellsPrimordial germ cellsEmbryonic gonadsOnset of oogenesisSomatic cellsNiche cellsGSC fatePole cellsStem cellsSpecific somatic cellsStem cell biologyTissue stem cellsDE-cadherinLarval gonadsPGC proliferationCell biologyLate larvalAdult ovariesOogenesisGerm cellsDrosophilaGonadsNanos Maintains Germline Stem Cell Self-Renewal by Preventing Differentiation
Wang Z, Lin H. Nanos Maintains Germline Stem Cell Self-Renewal by Preventing Differentiation. Science 2004, 303: 2016-2019. PMID: 14976263, DOI: 10.1126/science.1093983.Peer-Reviewed Original ResearchConceptsGermline stem cellsPrimordial germ cellsGermline cystsStem Cell Self-RenewalTranslational repressor NanosCell Self-RenewalStem cellsDrosophila ovaryGene regulationExtrinsic signalingPrecocious entrySelf-RenewalGerm cellsCell typesDifferentiation factorCellsCystoblastsOogenesisSignalingDifferentiationRegulationOvariesTranslation
2003
Screens for piwi Suppressors in Drosophila Identify Dosage-Dependent Regulators of Germline Stem Cell Division
Smulders-Srinivasan TK, Lin H. Screens for piwi Suppressors in Drosophila Identify Dosage-Dependent Regulators of Germline Stem Cell Division. Genetics 2003, 165: 1971-1991. PMID: 14704180, PMCID: PMC1462913, DOI: 10.1093/genetics/165.4.1971.Peer-Reviewed Original ResearchMeSH KeywordsAnimalsAnimals, Genetically ModifiedArgonaute ProteinsCell DivisionChromosomesDrosophilaDrosophila ProteinsFemaleGene DosageGene Expression Regulation, DevelopmentalGenes, LethalGerm CellsInfertility, MaleMaleProteinsRNA-Induced Silencing ComplexStem CellsSuppression, GeneticTranscription, GeneticZygoteConceptsStem cell divisionGermline stem cell divisionGenes/sequencesCell divisionFemale-specific lethalityDosage-dependent regulatorGermline stem cellsStem cell maintenanceDrosophila third chromosomeFamily of genesDosage-sensitive mannerPiwi mutantsZygotic functionMutant backgroundPiwi genesThird chromosomeMale germlineMale sterilitySuppressor mutationsSuch genesCell maintenanceGenetic regulationPlant kingdomTranscription factorsTranscriptional levelTo be and not to be
Lin H. To be and not to be. Nature 2003, 425: 353-355. PMID: 14508468, DOI: 10.1038/425353a.Peer-Reviewed Original Research