2014
PIWI proteins and PIWI-interacting RNAs in the soma
Ross RJ, Weiner MM, Lin H. PIWI proteins and PIWI-interacting RNAs in the soma. Nature 2014, 505: 353-359. PMID: 24429634, PMCID: PMC4265809, DOI: 10.1038/nature12987.Peer-Reviewed Original ResearchConceptsPIWI-interacting RNAsPIWI proteinsPIWI-piRNA pathwayDiscovery of millionsWhole-body regenerationStem cell functionSomatic functionsDiverse organismsLower eukaryotesGenome rearrangementsSomatic cellsEpigenetic programmingBiological rolePathwayRNAProteinRecent studiesEukaryotesTransposonOrganismsBiologyUnanticipated dimensionsFunctionCellsRearrangement
2011
Pinpointing the expression of piRNAs and function of the PIWI protein subfamily during spermatogenesis in the mouse
Beyret E, Lin H. Pinpointing the expression of piRNAs and function of the PIWI protein subfamily during spermatogenesis in the mouse. Developmental Biology 2011, 355: 215-226. PMID: 21539824, PMCID: PMC3443393, DOI: 10.1016/j.ydbio.2011.04.021.Peer-Reviewed Original ResearchConceptsPIWI proteinsXY bodyMouse testisAdult mouse testisEarly round spermatidsSex chromosomesGenomic sequencesPiRNAsChromatoid bodyCytological characterizationPachytene stageGerm cellsPhenotypic analysisAdult testisRound spermatidsProteinMeiosisSpermatogenesisCytoplasmDense bodiesSpermatocytesTestisPiRNAChromosomesTransposon
2010
Drosophila Piwi functions in Hsp90-mediated suppression of phenotypic variation
Gangaraju VK, Yin H, Weiner MM, Wang J, Huang XA, Lin H. Drosophila Piwi functions in Hsp90-mediated suppression of phenotypic variation. Nature Genetics 2010, 43: 153-158. PMID: 21186352, PMCID: PMC3443399, DOI: 10.1038/ng.743.Peer-Reviewed Original ResearchMeSH KeywordsAllelesAnimalsArgonaute ProteinsDNA Transposable ElementsDrosophila melanogasterDrosophila ProteinsElectrophoresis, Gel, Two-DimensionalEpigenesis, GeneticFemaleGene SilencingGenetic VariationGreen Fluorescent ProteinsHSP90 Heat-Shock ProteinsMaleOvaryPhenotypeRNA-Induced Silencing Complex
2007
Precancerous Stem Cells Have the Potential for both Benign and Malignant Differentiation
Chen L, Shen R, Ye Y, Pu XA, Liu X, Duan W, Wen J, Zimmerer J, Wang Y, Liu Y, Lasky LC, Heerema NA, Perrotti D, Ozato K, Kuramochi-Miyagawa S, Nakano T, Yates AJ, Carson WE, Lin H, Barsky SH, Gao JX. Precancerous Stem Cells Have the Potential for both Benign and Malignant Differentiation. PLOS ONE 2007, 2: e293. PMID: 17356702, PMCID: PMC1808425, DOI: 10.1371/journal.pone.0000293.Peer-Reviewed Original ResearchConceptsCancer stem cellsMalignant differentiationPrecancerous stem cellsStem cellsImmunocompetent miceImmunodeficient miceSolid cancersSolid tumorsTherapy of cancerC-kitNovel targetCancerEarly detectionCancer cellsSca-1Lineage markersTissue cellsMicePCSCsCellsSingle cloneDifferentiationTherapyTumorsPrevention
2004
Nanos Maintains Germline Stem Cell Self-Renewal by Preventing Differentiation
Wang Z, Lin H. Nanos Maintains Germline Stem Cell Self-Renewal by Preventing Differentiation. Science 2004, 303: 2016-2019. PMID: 14976263, DOI: 10.1126/science.1093983.Peer-Reviewed Original ResearchConceptsGermline stem cellsPrimordial germ cellsGermline cystsStem Cell Self-RenewalTranslational repressor NanosCell Self-RenewalStem cellsDrosophila ovaryGene regulationExtrinsic signalingPrecocious entrySelf-RenewalGerm cellsCell typesDifferentiation factorCellsCystoblastsOogenesisSignalingDifferentiationRegulationOvariesTranslation