2008
MILI, a PIWI-interacting RNA-binding Protein, Is Required for Germ Line Stem Cell Self-renewal and Appears to Positively Regulate Translation*
Unhavaithaya Y, Hao Y, Beyret E, Yin H, Kuramochi-Miyagawa S, Nakano T, Lin H. MILI, a PIWI-interacting RNA-binding Protein, Is Required for Germ Line Stem Cell Self-renewal and Appears to Positively Regulate Translation*. Journal Of Biological Chemistry 2008, 284: 6507-6519. PMID: 19114715, PMCID: PMC2649106, DOI: 10.1074/jbc.m809104200.Peer-Reviewed Original ResearchConceptsGerm line stem cellsStem cellsArgonaute/PIWI protein familyMicro-RNA pathwayGerm line developmentMammalian stem cellsPIWI-interacting RNAsCap-binding complexRNA-binding proteinPIWI protein familyCellular mRNA levelsStem cell populationSelf-renewing divisionsArgonaute functionsPIWI proteinsRegulates TranslationPIWI subfamiliesEpigenetic regulationProtein familyCell maintenanceRNA interferenceChromatoid bodyMILIMolecular mechanismsEarly spermatocytes
2002
Molecular characterization of hiwi, a human member of the piwi gene family whose overexpression is correlated to seminomas
Qiao D, Zeeman AM, Deng W, Looijenga LH, Lin H. Molecular characterization of hiwi, a human member of the piwi gene family whose overexpression is correlated to seminomas. Oncogene 2002, 21: 3988-3999. PMID: 12037681, DOI: 10.1038/sj.onc.1205505.Peer-Reviewed Original ResearchMeSH KeywordsAmino Acid SequenceArgonaute ProteinsBlotting, NorthernChildChromosome MappingChromosomes, Human, Pair 12Cloning, MolecularDNA PrimersDNA, ComplementaryDrosophila ProteinsFormazansGene LibraryHumansImmunoenzyme TechniquesIn Situ HybridizationMaleMolecular Sequence DataPolymerase Chain ReactionProteinsRNA, MessengerRNA-Induced Silencing ComplexSeminomaSequence Homology, Amino AcidTeratomaTesticular NeoplasmsTetrazolium SaltsConceptsGene familyPiwi gene familyHuman membersGerm cellsMolecular characterizationPiwi family genesPIWI family proteinsEnhanced expressionEmbryonic germ cellsGerm cell phenotypeGerm cell characteristicsGerm cell proliferationStage-dependent patternDiverse organismsDrosophila melanogasterC. elegansGermline cellsGenomic regionsFamily genesFamily proteinsSignificant homologySame precursor cellRNA interferenceChromosomal regionsKb mRNA