2016
Change point analysis of histone modifications reveals epigenetic blocks linking to physical domains
Chen M, Lin H, Zhao H. Change point analysis of histone modifications reveals epigenetic blocks linking to physical domains. The Annals Of Applied Statistics 2016, 10: 506-526. PMID: 27231496, PMCID: PMC4876974, DOI: 10.1214/16-aoas905.Peer-Reviewed Original ResearchHistone modificationsHistone marksLocal chromatin environmentDistribution of genesWhole-genome analysisRelevant biological functionsEnrichment patternsSimilar enrichment patternsHigh-throughput techniquesChromatin environmentChromatin organizationEpigenetic blockTranscriptional outputGene regulationTranscriptional controlOrchestrated regulationEpigenetic mechanismsGO enrichmentTranscription levelsBiological functionsCombinatorial patternsGenomeGenesRegulationEukaryotes
2014
Noncoding RNAs in the regulation of DNA replication
Ge XQ, Lin H. Noncoding RNAs in the regulation of DNA replication. Trends In Biochemical Sciences 2014, 39: 341-343. PMID: 25027733, PMCID: PMC4265214, DOI: 10.1016/j.tibs.2014.06.003.Peer-Reviewed Original ResearchPIWI proteins and PIWI-interacting RNAs in the soma
Ross RJ, Weiner MM, Lin H. PIWI proteins and PIWI-interacting RNAs in the soma. Nature 2014, 505: 353-359. PMID: 24429634, PMCID: PMC4265809, DOI: 10.1038/nature12987.Peer-Reviewed Original ResearchConceptsPIWI-interacting RNAsPIWI proteinsPIWI-piRNA pathwayDiscovery of millionsWhole-body regenerationStem cell functionSomatic functionsDiverse organismsLower eukaryotesGenome rearrangementsSomatic cellsEpigenetic programmingBiological rolePathwayRNAProteinRecent studiesEukaryotesTransposonOrganismsBiologyUnanticipated dimensionsFunctionCellsRearrangement