2024
The extension of mammalian pregnancy required taming inflammation: Independent evolution of extended placentation in the tammar wallaby
Dudley J, Renfree M, Wagner G, Griffith O. The extension of mammalian pregnancy required taming inflammation: Independent evolution of extended placentation in the tammar wallaby. Proceedings Of The National Academy Of Sciences Of The United States Of America 2024, 121: e2310047121. PMID: 39378090, PMCID: PMC11494332, DOI: 10.1073/pnas.2310047121.Peer-Reviewed Original ResearchConceptsLive-bearing mammalsTammar wallabyInflammatory reactionMode of reproductionCompare gene expression changesMaternal-fetal interactionsGene expression changesMarsupial taxaPeriod of placentationIndependent evolutionMammalian pregnancyMarsupial speciesEutheriansFat-tailed dunnartExpression changesInflammatory genesInflammationPlacentationWallabyEpitheliochorial placentation
2008
Adaptive changes in the transcription factor HoxA-11 are essential for the evolution of pregnancy in mammals
Lynch VJ, Tanzer A, Wang Y, Leung FC, Gellersen B, Emera D, Wagner GP. Adaptive changes in the transcription factor HoxA-11 are essential for the evolution of pregnancy in mammals. Proceedings Of The National Academy Of Sciences Of The United States Of America 2008, 105: 14928-14933. PMID: 18809929, PMCID: PMC2567470, DOI: 10.1073/pnas.0802355105.Peer-Reviewed Original ResearchConceptsCis-regulatory elementsHoxa-11Evolutionary changePlacental mammalsEutherian mammalsTranscription factorsCis-regulatory evolutionDirect regulatory targetsGene expression domainsStrong positive selectionNovel developmental pathwayPRL expressionTherian ancestorGene regulationExpression domainsPositive selectionRegulatory targetsNovel functionDevelopmental pathwaysMammalsSpatial expressionProlactin expressionGenesExpressionAdaptive changes