2024
The mammary hair of Monodelphis domestica and homology of the mammary pilosebacous unit
Stadtmauer D, Wagner G. The mammary hair of Monodelphis domestica and homology of the mammary pilosebacous unit. Journal Of Morphology 2024, 285: e21769. PMID: 39188032, DOI: 10.1002/jmor.21769.Peer-Reviewed Original Research
2012
Origin of the Endometrial Gene Regulatory Network of Placental Mammals.
Wagner G, Lynch V, Nnamani M. Origin of the Endometrial Gene Regulatory Network of Placental Mammals. Biology Of Reproduction 2012, 87: 33-33. DOI: 10.1093/biolreprod/87.s1.33.Peer-Reviewed Original ResearchGene regulatory networksTransposable elementsPlacental mammalsRegulatory networksComparative transcriptome sequencingSpecific transposable elementsRegulatory network changesCis-regulatory elementsGene expression patternsDecidual cell typesChromatin marksGene regulationStem lineageTranscriptome sequencingChromatin immunoprecipitationRegulatory elementsInvasive placentationExpression patternsDerived characterAryl hydrocarbon receptorGenesCell typesMammalsRegulatory activityStromal cells
2008
Adaptive changes in the transcription factor HoxA-11 are essential for the evolution of pregnancy in mammals
Lynch VJ, Tanzer A, Wang Y, Leung FC, Gellersen B, Emera D, Wagner GP. Adaptive changes in the transcription factor HoxA-11 are essential for the evolution of pregnancy in mammals. Proceedings Of The National Academy Of Sciences Of The United States Of America 2008, 105: 14928-14933. PMID: 18809929, PMCID: PMC2567470, DOI: 10.1073/pnas.0802355105.Peer-Reviewed Original ResearchConceptsCis-regulatory elementsHoxa-11Evolutionary changePlacental mammalsEutherian mammalsTranscription factorsCis-regulatory evolutionDirect regulatory targetsGene expression domainsStrong positive selectionNovel developmental pathwayPRL expressionTherian ancestorGene regulationExpression domainsPositive selectionRegulatory targetsNovel functionDevelopmental pathwaysMammalsSpatial expressionProlactin expressionGenesExpressionAdaptive changes
2004
Adaptive evolution of HoxA11 and HoxA13 at the origin of the uterus in mammals
Lynch V, Roth J, Takahashi K, Dunn C, Nonaka D, Stopper G, Wagner G. Adaptive evolution of HoxA11 and HoxA13 at the origin of the uterus in mammals. Proceedings Of The Royal Society B 2004, 271: 2201-2207. PMID: 15539344, PMCID: PMC1691855, DOI: 10.1098/rspb.2004.2848.Peer-Reviewed Original ResearchConceptsAdaptive evolutionTranscription factorsMolecular evolutionHoxa-11Hoxa-13Cis-regulatory evolutionAdaptive molecular evolutionEvolution of developmentMammalian female reproductive systemStrong positive selectionCis-regulatory elementsAmniote taxaDevelopmental genesStem lineageDevelopmental evolutionEvolutionary changeEutherian mammalsSpatial regulationPositive selectionMorphological charactersFemale reproductive organsGenesFemale reproductive systemReproductive organsMammals