2014
Reinventing the Organism: Evolvability and Homology in Post-Dahlem Evolutionary Biology
Wagner G. Reinventing the Organism: Evolvability and Homology in Post-Dahlem Evolutionary Biology. Boston Studies In The Philosophy And History Of Science 2014, 307: 327-342. DOI: 10.1007/978-94-017-9412-1_15.Peer-Reviewed Original ResearchEvolutionary biologyDahlem ConferenceGenotype-phenotype mapStructure of organismsLimited pleiotropyNatural selectionEvolutionary causationPhenotype evolutionOrganism conceptRandom mutationsHomologyOrganismsEvolvabilityBiologyDevelopmental structuresMutationsDevelopmental organizationPleiotropySeedsFitnessSelectionAdaptation
2012
Coming to Grips with Evolvability
Pavlicev M, Wagner G. Coming to Grips with Evolvability. Evolution: Education And Outreach 2012, 5: 231-244. DOI: 10.1007/s12052-012-0430-1.Peer-Reviewed Original ResearchGenotype-phenotype mapOrganismal developmentMost genesCryptic mutationsPhenotypic traitsComplex organismsPhenotypic charactersMost traitsRandom mutationsReal organismsGenetic effectsEvolvabilityGenetic backgroundOrganismsGenesMutationsTraitsNew environmentRandom changesPhenotypeFitnessEvolutionSelectionConventional computer languages
2001
Epistasis and the Mutation Load: A Measurement-Theoretical Approach
Hansen T, Wagner G. Epistasis and the Mutation Load: A Measurement-Theoretical Approach. Genetics 2001, 158: 477-485. PMID: 11333254, PMCID: PMC1461645, DOI: 10.1093/genetics/158.1.477.Peer-Reviewed Original ResearchConceptsMutation-selection equilibriumGene interactionsEpistatic interactionsMutation loadStrength of epistasisMutation-selection balanceGenomic mutation rateHigher-order gene interactionsSynergistic epistasisMean fitnessOptimal genotypeEpistatic effectsTwofold disadvantageEpistasisMutation rateGenetic backgroundSynergistic interactionSystematic relationshipGenesLociInteraction intensityInteractionFitnessInteraction densityGenotypes