2015
Evolutionary innovations and novelties: Let us get down to business!
Wagner G. Evolutionary innovations and novelties: Let us get down to business! Zoologischer Anzeiger 2015, 256: 75-81. DOI: 10.1016/j.jcz.2015.04.006.Peer-Reviewed Original ResearchCore gene regulatory networkGene regulatory networksRegulatory networksNovel body partsEvolutionary innovationEvolutionary developmental biologyCore regulatory networkBody part identityEvolutionary noveltyEvolutionary biologistsEvolutionary biologyDevelopmental biologyEvolutionary changeBiological processesCell typesImportant unanswered questionsBiologyCritical insightsGenomicsRecent advancesMechanistic aspectsGenesBiologistsUnanswered questionsBody partsHomology in the Age of Developmental Genomics
Wagner G. Homology in the Age of Developmental Genomics. 2015, 25-43. DOI: 10.1007/978-3-7091-1862-7_2.Peer-Reviewed Original ResearchModel organismsEvolutionary biologyHomology conceptRecent common ancestorDevelopmental genomicsPhylogenetic relationshipsCommon ancestorDarwinian traditionHomologySame organOrganismsSpeciesComparative anatomyDifferent animalsBiologistsBiologyFundamental roleRichard OwenImportant roleGenomicsAncestorGenesOrgansHumansRole
2014
Reinventing the Organism: Evolvability and Homology in Post-Dahlem Evolutionary Biology
Wagner G. Reinventing the Organism: Evolvability and Homology in Post-Dahlem Evolutionary Biology. Boston Studies In The Philosophy And History Of Science 2014, 307: 327-342. DOI: 10.1007/978-94-017-9412-1_15.Peer-Reviewed Original ResearchEvolutionary biologyDahlem ConferenceGenotype-phenotype mapStructure of organismsLimited pleiotropyNatural selectionEvolutionary causationPhenotype evolutionOrganism conceptRandom mutationsHomologyOrganismsEvolvabilityBiologyDevelopmental structuresMutationsDevelopmental organizationPleiotropySeedsFitnessSelectionAdaptation
2009
Measuring Morphological Integration Using Eigenvalue Variance
Pavlicev M, Cheverud J, Wagner G. Measuring Morphological Integration Using Eigenvalue Variance. Evolutionary Biology 2009, 36: 157-170. DOI: 10.1007/s11692-008-9042-7.Peer-Reviewed Original Research
2008
Pleiotropic scaling of gene effects and the ‘cost of complexity’
Wagner GP, Kenney-Hunt JP, Pavlicev M, Peck JR, Waxman D, Cheverud JM. Pleiotropic scaling of gene effects and the ‘cost of complexity’. Nature 2008, 452: 470-472. PMID: 18368117, DOI: 10.1038/nature06756.Peer-Reviewed Original ResearchConceptsQuantitative trait lociEffects of pleiotropyOrganismal complexityGenetic sequence dataHigher organismsEvolutionary biologyTrait lociMouse genomeSequence dataBiology questionsSkeletal traitsGene effectsMost mutationsCost of complexityGenetic mutationsTraitsMutationsMultiple effectsGenomeSkeletal characteristicsPleiotropyLociPleiotropicOrganismsBiology
2007
The road to modularity
Wagner GP, Pavlicev M, Cheverud JM. The road to modularity. Nature Reviews Genetics 2007, 8: 921-931. PMID: 18007649, DOI: 10.1038/nrg2267.Peer-Reviewed Original ResearchConceptsProtein-protein interaction networkMolecular systems biologyPatterns of evolutionGene duplicationGene regulationEvolutionary biologyNeutral mutationsBiological organizationQuantitative traitsInteraction networksSystems biologyStructure of macromoleculesEnvironmental conditionsBiologyDuplicationTraitsMutationsRegulationSelectionModularityMacromolecules
2005
Natural Selection and the Origin of Modules
Wagner G, Mezey J, Calabretta R. Natural Selection and the Origin of Modules. 2005, 33-50. DOI: 10.7551/mitpress/4734.003.0009.Peer-Reviewed Original ResearchCognitive scienceArtificial lifeEvolutionary biologyHerbert A. SimonScientific revolutionDifferent disciplinary contextsVariety of disciplinesLatest theoriesA. SimonDisciplinary contextsScienceScientific discussionNatural selectionDominant themesDisciplinesSpecialized conceptsArtLifeMathematicsResearch agendaEconomicsPhilosophyConceptComputer scienceBiology
2000
Developmental Evolution as a Mechanistic Science: The Inference from Developmental Mechanisms to Evolutionary Processes1
Wagner G, Chiu C, Laubichler M. Developmental Evolution as a Mechanistic Science: The Inference from Developmental Mechanisms to Evolutionary Processes1. Integrative And Comparative Biology 2000, 40: 819-831. DOI: 10.1668/0003-1569(2000)040[0819:deaams]2.0.co;2.Peer-Reviewed Reviews, Practice Guidelines, Standards, and Consensus StatementsDevelopmental evolutionEvolutionary innovationDevelopmental mechanismsFunction of genesEvolutionary geneticsGenetic architectureEvolutionary originEvolutionary biologyAssessment of homologyDevelopmental dynamicsSpecies differencesBiologyGenetic factorsHomologyGenesMechanismGeneticsSpeciesEvolutionRoleElucidationOriginMechanistic scienceCharacterDevelopmental Evolution as a Mechanistic Science: The Inference from Developmental Mechanisms to Evolutionary Processes1
Wagner G, Chiu C, Laubichler M. Developmental Evolution as a Mechanistic Science: The Inference from Developmental Mechanisms to Evolutionary Processes1. Integrative And Comparative Biology 2000, 40: 819-831. DOI: 10.1093/icb/40.5.819.Peer-Reviewed Original ResearchDevelopmental evolutionEvolutionary innovationDevelopmental mechanismsFunction of genesEvolutionary geneticsGenetic architectureEvolutionary originEvolutionary biologyAssessment of homologyDevelopmental dynamicsSpecies differencesBiologyGenetic factorsHomologyGenesMechanismGeneticsSpeciesEvolutionRoleElucidationOriginMechanistic scienceCharacterCharacter identification in evolutionary biology: The role of the organism
Wagner G, Laubichler M. Character identification in evolutionary biology: The role of the organism. Theory In Biosciences 2000, 119: 20-40. DOI: 10.1007/s12064-000-0003-7.Peer-Reviewed Reviews, Practice Guidelines, Standards, and Consensus StatementsBiological processesBiological charactersImportant biological charactersHigher-level biological processesAdaptive evolutionEvolutionary biologyMathematical theoryRelevant charactersMathematical modelCharacter decompositionOrganismsBiologyOrganismic perspectiveBiological modelsPhysical sciencesBiological theoryIdentificationTheoryTraitsInheritanceModelAnalytical methodCellsCharacterAppropriate instances