2010
Molecular characterization of two novel milk proteins in the tsetse fly (Glossina morsitans morsitans)
Yang G, Attardo GM, Lohs C, Aksoy S. Molecular characterization of two novel milk proteins in the tsetse fly (Glossina morsitans morsitans). Insect Molecular Biology 2010, 19: 253-262. PMID: 20136662, PMCID: PMC2862765, DOI: 10.1111/j.1365-2583.2009.00987.x.Peer-Reviewed Original ResearchConceptsViviparous reproductionKnockdown fliesRNA interferenceMilk protein genesTranscriptional regulation mechanismPotential phosphorylation sitesIntrauterine larval developmentRNA interference treatmentSpecific gene expressionTissue-specific expressionNovel milk proteinsSpecific expression profilesTsetse fliesHydrophobic amino acidsMajor milk proteinsNorthern blot analysisIntrauterine larvaeNovel genesPhosphorylation sitesProtein functionRT-PCR analysisTranscript abundanceProtein geneCDNA libraryGland proteins
2009
Interactions between mutualist Wigglesworthia and tsetse peptidoglycan recognition protein (PGRP-LB) influence trypanosome transmission
Wang J, Wu Y, Yang G, Aksoy S. Interactions between mutualist Wigglesworthia and tsetse peptidoglycan recognition protein (PGRP-LB) influence trypanosome transmission. Proceedings Of The National Academy Of Sciences Of The United States Of America 2009, 106: 12133-12138. PMID: 19587241, PMCID: PMC2715537, DOI: 10.1073/pnas.0901226106.Peer-Reviewed Original ResearchConceptsImmune deficiencyPGRP-LBHost immune responsePeptidoglycan recognition proteinsAnti-protozoal activityTsetse's abilityImmune responseInfection susceptibilityHost immunityExpression correlatesNormal adultsInfectionHost susceptibilityAntimicrobial peptidesParasitized adultsTrypanosome infectionAdult tsetseRecognition proteinsLimited exposureAdultsForeign microbesRNA interferencePathway functionActivationSusceptibility