2014
Novel inflammatory biomarkers of portal pressure in compensated cirrhosis patients
Buck M, Garcia‐Tsao G, Groszmann RJ, Stalling C, Grace ND, Burroughs AK, Patch D, Matloff DS, Clopton P, Chojkier M. Novel inflammatory biomarkers of portal pressure in compensated cirrhosis patients. Hepatology 2014, 59: 1052-1059. PMID: 24115225, DOI: 10.1002/hep.26755.Peer-Reviewed Original ResearchConceptsHepatic vein pressure gradientGastroesophageal varicesCirrhosis patientsUnnecessary esophagogastroduodenoscopyPortal hypertensionInflammatory biomarkersMultivariate logistic regression analysisInflammatory serum biomarkersNovel inflammatory biomarkerSerum VCAM-1Logistic regression analysisAssociated morbidityCohort studyPortal pressureLiver injuryBlood testsClinical parametersInflammatory pathwaysSerum biomarkersClinical trialsVCAM-1IL-1RPatientsDiagnostic testsMmHg
2012
Prognostic indicators of survival in patients with compensated and decompensated cirrhosis
Zipprich A, Garcia‐Tsao G, Rogowski S, Fleig WE, Seufferlein T, Dollinger MM. Prognostic indicators of survival in patients with compensated and decompensated cirrhosis. Liver International 2012, 32: 1407-1414. PMID: 22679906, PMCID: PMC3713489, DOI: 10.1111/j.1478-3231.2012.02830.x.Peer-Reviewed Original ResearchConceptsHepatic venous pressure gradientPredictors of deathCompensated patientsPortal hypertensionPrognostic valueComplications of cirrhosisSignificant portal hypertensionStage 2 patientsVenous pressure gradientDecompensated patientsSystemic haemodynamicsVariceal hemorrhagePortal pressureIndependent predictorsMultivariable analysisClinical eventsDecompensated stagePrognostic indicatorStaging systemLonger survivalBACKGROUND/CirrhosisPatientsSurvival rateAnalyse survival
2008
Hepatic Vascular Malformations in Hereditary Hemorrhagic Telangiectasia
Khalid S, Garcia-Tsao G. Hepatic Vascular Malformations in Hereditary Hemorrhagic Telangiectasia. Seminars In Liver Disease 2008, 28: 247-258. PMID: 18814078, DOI: 10.1055/s-0028-1085093.Peer-Reviewed Reviews, Practice Guidelines, Standards, and Consensus StatementsConceptsHereditary hemorrhagic telangiectasiaHepatic arteryVascular malformationsHepatic veinPortal veinHemorrhagic telangiectasiaHigh-output cardiac failureAbnormal vascular communicationAggressive medical therapyHepatic vascular malformationsPredominant clinical presentationCommon hepatic arteryNodular regenerative hyperplasiaIntensive medical treatmentFocal nodular hyperplasiaAutosomal dominant vascular disorderAbdominal anginaBiliary ischemiaLiver transplantationPortal hypertensionRegenerative hyperplasiaSymptomatic patientsCommon presentationMedical therapyCardiac failure
2002
Assessment of therapeutic benefit of antiviral therapy in chronic hepatitis C: is hepatic venous pressure gradient a better end point?
Burroughs A, Groszmann R, Bosch J, Grace N, Garcia-Tsao G, Patch D, Garcia-Pagan J, Dagher L. Assessment of therapeutic benefit of antiviral therapy in chronic hepatitis C: is hepatic venous pressure gradient a better end point? Gut 2002, 50: 425. PMID: 11839726, PMCID: PMC1773121, DOI: 10.1136/gut.50.3.425.Peer-Reviewed Original ResearchMeSH KeywordsAntiviral AgentsHepatic VeinsHepatitis C, ChronicHumansTreatment OutcomeVenous PressureConceptsHepatic venous pressure gradientChronic hepatitis CVenous pressure gradientHepatitis CAntiviral therapyEnd pointChronic hepatitis C.Major healthcare problemBest end pointHepatitis C.HVPG measurementTherapeutic benefitTherapeutic evaluationTherapyHealthcare problemPatientsPressure gradientResponse
1999
Low‐dose midazolam sedation: An option for patients undergoing serial hepatic venous pressure measurements
Steinlauf A, Garcia‐Tsao G, Zakko M, Dickey K, Gupta T, Groszmann R. Low‐dose midazolam sedation: An option for patients undergoing serial hepatic venous pressure measurements. Hepatology 1999, 29: 1070-1073. PMID: 10094948, DOI: 10.1002/hep.510290421.Peer-Reviewed Original ResearchConceptsHepatic venous pressure gradientHepatic venous pressure measurementsWedged hepatic venous pressureFree hepatic venous pressureVenous pressure measurementsHepatic venous pressurePortal hypertensionVenous pressureSerial measurementsPatient comfortVenous pressure gradientDoses of midazolamDouble-blind studyDose of midazolamHigh-dose midazolamEffects of midazolamEffects of sedativesPortal pressure measurementsPressure measurementsCompensated cirrhosisVariceal hemorrhageCirrhotic patientsPharmacological therapyMidazolam sedationPrognostic index
1987
Hemodynamic evaluation of isosorbide dinitrate in alcoholic cirrhosis Pharmacokinetic-hemodynamic interactions
Blei A, Garcia-Tsao G, Groszmann R, Kahrilas P, Ganger D, Morse S, Fung H. Hemodynamic evaluation of isosorbide dinitrate in alcoholic cirrhosis Pharmacokinetic-hemodynamic interactions. Gastroenterology 1987, 93: 576-583. PMID: 3301517, DOI: 10.1016/0016-5085(87)90921-8.Peer-Reviewed Original ResearchConceptsIsosorbide dinitratePortal pressureArterial pressureHemodynamic changesHemodynamic evaluationHepatic vein wedge pressureHepatic venous gradientSystemic hemodynamic changesMean arterial pressureEffects of placeboValues 4 hStable cirrhoticsAlcoholic cirrhosisCardiac indexPortal hypertensionWedge pressureHemodynamic benefitsVenous gradientVasoactive metabolitesPharmacologic agentsIndividual patientsBaseline valuesExperimental animalsDinitratePatientsPortal hemodynamics during nitroglycerin administration in cirrhotic patients
Garcia‐Tsao G, Groszmann R. Portal hemodynamics during nitroglycerin administration in cirrhotic patients. Hepatology 1987, 7: 805-809. PMID: 3115881, DOI: 10.1002/hep.1840070502.Peer-Reviewed Original ResearchConceptsHepatic venous pressure gradientVenous pressure gradientEffects of nitroglycerinMean arterial pressurePortal pressureArterial pressureNitroglycerin administrationBlood flowExperimental animalsAzygos blood flowPortal venous hemodynamicsPortal hypertensive patientsPortal blood flowVenous dilatorHypertensive patientsAlcoholic cirrhosisArterial vasodilatorCirrhotic patientsBlood pressurePortal hemodynamicsSublingual nitroglycerinVenous hemodynamicsHemodynamic responsePeak changesHeart rate