2010
Sildenafil Has No Effect on Portal Pressure but Lowers Arterial Pressure in Patients With Compensated Cirrhosis
Tandon P, Inayat I, Tal M, Spector M, Shea M, Groszmann RJ, Garcia–Tsao G. Sildenafil Has No Effect on Portal Pressure but Lowers Arterial Pressure in Patients With Compensated Cirrhosis. Clinical Gastroenterology And Hepatology 2010, 8: 546-549. PMID: 20144739, PMCID: PMC2879450, DOI: 10.1016/j.cgh.2010.01.017.Peer-Reviewed Original ResearchConceptsHepatic venous pressure gradientMean arterial pressurePortal pressureArterial pressureHeart rateBaseline hepatic venous pressure gradientMedian mean arterial pressureOpen-label pilot studyPhosphodiesterase-5 inhibitor sildenafilSystemic vasodilatory effectVenous pressure gradientEffect of sildenafilPortal venous inflowIntrahepatic resistanceOral sildenafilCompensated cirrhosisCirrhotic patientsVasodilatory effectChild APortal hemodynamicsErectile dysfunctionVenous inflowInhibitor sildenafilTherapeutic dosesPatients
2009
Incidence, Prevalence, and Clinical Significance of Abnormal Hematologic Indices in Compensated Cirrhosis
Qamar AA, Grace ND, Groszmann RJ, Garcia–Tsao G, Bosch J, Burroughs AK, Ripoll C, Maurer R, Planas R, Escorsell A, Garcia–Pagan J, Patch D, Matloff DS, Makuch R, Rendon G, Group P. Incidence, Prevalence, and Clinical Significance of Abnormal Hematologic Indices in Compensated Cirrhosis. Clinical Gastroenterology And Hepatology 2009, 7: 689-695. PMID: 19281860, PMCID: PMC4545534, DOI: 10.1016/j.cgh.2009.02.021.Peer-Reviewed Original ResearchConceptsHepatic venous pressure gradientHematologic indicesCompensated cirrhosisBaseline hepatic venous pressure gradientWhite blood cell countChild-Pugh scorePredictors of deathPrimary end pointVenous pressure gradientDevelopment of varicesKaplan-Meier analysisBlood cell countCombination of leukopeniaBaseline thrombocytopeniaVariceal bleedingClinical decompensationEsophageal varicesPrognostic significanceTransplant surgeryClinical significanceLeukopeniaThrombocytopeniaCirrhosisCell countVarices
1989
Long‐term hemodynamic effects of ketanserin, a 5‐hydroxytryptamine blocker, in portal hypertensive patients
Vorobioff J, Garcia‐Tsao G, Groszmann R, Aceves G, Picabea E, Villavicencio R, Hernandez‐Ortiz J. Long‐term hemodynamic effects of ketanserin, a 5‐hydroxytryptamine blocker, in portal hypertensive patients. Hepatology 1989, 9: 88-91. PMID: 2908873, DOI: 10.1002/hep.1840090114.Peer-Reviewed Original ResearchConceptsHepatic venous pressure gradientPortal hypertensive patientsVenous pressure gradientMean arterial pressureHypertensive patientsCardiac indexArterial pressureMean baseline hepatic venous pressure gradientBaseline hepatic venous pressure gradientLong-term hemodynamic effectsAcute hemodynamic studyChronic oral administrationHepatic venous pressurePoor liver functionAlcoholic cirrhosisPortal hypertensionReceptor blockersHemodynamic effectsPortal pressurePortosystemic encephalopathyChronic treatmentVenous pressureLiver functionMean doseHemodynamic studies
1986
Short‐term effects of propranolol on portal venous pressure
Garcia‐Tsao G, Grace N, Groszmann R, Conn H, Bermann M, Patrick M, Morse S, Alberts J. Short‐term effects of propranolol on portal venous pressure. Hepatology 1986, 6: 101-106. PMID: 3943775, DOI: 10.1002/hep.1840060119.Peer-Reviewed Original ResearchConceptsHepatic venous pressure gradientVenous pressure gradientPropranolol plasma levelsHeart rateVenous pressurePlasma levelsMean baseline hepatic venous pressure gradientBaseline hepatic venous pressure gradientHepatic venous pressureBlood pressure responsePortal venous pressureEffect of propranololBaseline laboratoryAlcoholic cirrhosisPortal hypertensionPortal pressureLaboratory parametersLiver diseasePropranolol administrationAdditional dosesHemodynamic parametersOral administrationShort-term effectsPropranololPatients