2012
Combined assessment of sex- and mutation-specific information for risk stratification in type 1 long QT syndrome
Costa J, Lopes CM, Barsheshet A, Moss AJ, Migdalovich D, Ouellet G, McNitt S, Polonsky S, Robinson JL, Zareba W, Ackerman MJ, Benhorin J, Kaufman ES, Platonov PG, Shimizu W, Towbin JA, Vincent GM, Wilde AA, Goldenberg I. Combined assessment of sex- and mutation-specific information for risk stratification in type 1 long QT syndrome. Heart Rhythm 2012, 9: 892-898. PMID: 22293141, PMCID: PMC3358462, DOI: 10.1016/j.hrthm.2012.01.020.Peer-Reviewed Original ResearchConceptsCardiac eventsLife-threatening cardiac eventsSex-specific risk factorsSex-specific riskAge 40 yearsLife-threatening eventsType 1 long QT syndromeLong QT syndromeRisk stratificationRisk factorsQT intervalHigh riskTime-dependent differencesQT syndromeMultivariate analysisLQT1WomenCombined assessmentKCNQ1 geneDisease-causing mutationsMenRiskOnset of adolescenceMutation-specific informationSCD
2011
Mutation and gender-specific risk in type 2 long QT syndrome: Implications for risk stratification for life-threatening cardiac events in patients with long QT syndrome
Migdalovich D, Moss AJ, Lopes CM, Costa J, Ouellet G, Barsheshet A, McNitt S, Polonsky S, Robinson JL, Zareba W, Ackerman MJ, Benhorin J, Kaufman ES, Platonov PG, Shimizu W, Towbin JA, Vincent GM, Wilde AA, Goldenberg I. Mutation and gender-specific risk in type 2 long QT syndrome: Implications for risk stratification for life-threatening cardiac events in patients with long QT syndrome. Heart Rhythm 2011, 8: 1537-1543. PMID: 21440677, PMCID: PMC4028036, DOI: 10.1016/j.hrthm.2011.03.049.Peer-Reviewed Original ResearchMeSH KeywordsAdolescentAdultChildChild, PreschoolChi-Square DistributionDeath, Sudden, CardiacERG1 Potassium ChannelEther-A-Go-Go Potassium ChannelsFemaleHeart ArrestHumansInfantInfant, NewbornLong QT SyndromeMaleMutationProbabilityProportional Hazards ModelsRegistriesRisk AssessmentSex FactorsStatistics, NonparametricSurvival AnalysisConceptsLife-threatening cardiac eventsCardiac eventsLong QT syndromeGender-specific riskRisk stratificationQT syndromeKCNH2 channelsImproved risk stratificationType 2 long QT syndromeAge 40 yearsLife-threatening eventsLQT2 womenFemale patientsHigh riskLQT2 patientsTime-dependent differencesMultivariate analysisPatientsCombined assessmentCumulative probabilityWomenDisease-causing mutationsLoop mutationsMenRisk
2010
Long QT Syndrome in African‐Americans
Fugate T, Moss AJ, Jons C, McNitt S, Mullally J, Ouellet G, Goldenberg I, Zareba W, Robinson JL, Investigators F. Long QT Syndrome in African‐Americans. Annals Of Noninvasive Electrocardiology 2010, 15: 73-76. PMID: 20146785, PMCID: PMC4028024, DOI: 10.1111/j.1542-474x.2009.00342.x.Peer-Reviewed Original ResearchMeSH KeywordsAdolescentAdrenergic beta-AntagonistsAdultAge DistributionBlack or African AmericanChildChild, PreschoolDeath, Sudden, CardiacFemaleHeart ArrestHumansInfantInfant, NewbornKaplan-Meier EstimateLong QT SyndromeMaleProportional Hazards ModelsRegistriesRisk FactorsSyncopeUnited StatesWhite PeopleYoung AdultConceptsLong QT syndromeClinical courseRisk factorsQT syndromeAfrican AmericansBeta-blocker therapyCardiac event rateComparable risk factorsKaplan-Meier timeSudden cardiac deathAge 40 yearsAfrican American patientsCox regression modelInternational LQTS RegistryOccurrence of syncopeRisk factor evaluationDecade of birthCardiac eventsCardiac deathCox analysisCardiac arrestLQTS RegistryMedical historyRacial groupsLQTS patients
2009
Influence of Diabetes Mellitus on Outcome in Patients Over 40 Years of Age With the Long QT Syndrome
Ouellet G, Moss AJ, Jons C, McNitt S, Mullally J, Fugate T, Goldenberg I, Zareba W, Robinson JL, Registry I. Influence of Diabetes Mellitus on Outcome in Patients Over 40 Years of Age With the Long QT Syndrome. The American Journal Of Cardiology 2009, 105: 87-89. PMID: 20102896, PMCID: PMC2813216, DOI: 10.1016/j.amjcard.2009.08.657.Peer-Reviewed Original ResearchConceptsYears of ageFirst cardiac eventLong QT syndromeCardiac eventsQTc intervalRisk factorsAdult patientsDiabetes mellitusQT syndromeEnd pointIndependent mortality riskOral diabetic medicationsProlonged QTc intervalImpact of diabetesDevelopment of diabetesBeats/minInternational Long QT Syndrome RegistryCause mortalityDiabetic medicationsOlder patientsStudy populationVentricular repolarizationMortality riskHeart rateCox modelClinical Implications for Patients With Long QT Syndrome Who Experience a Cardiac Event During Infancy
Spazzolini C, Mullally J, Moss AJ, Schwartz PJ, McNitt S, Ouellet G, Fugate T, Goldenberg I, Jons C, Zareba W, Robinson JL, Ackerman MJ, Benhorin J, Crotti L, Kaufman ES, Locati EH, Qi M, Napolitano C, Priori SG, Towbin JA, Vincent GM. Clinical Implications for Patients With Long QT Syndrome Who Experience a Cardiac Event During Infancy. Journal Of The American College Of Cardiology 2009, 54: 832-837. PMID: 19695463, PMCID: PMC3517782, DOI: 10.1016/j.jacc.2009.05.029.Peer-Reviewed Original ResearchConceptsSudden cardiac deathLong QT syndromeCardiac eventsQT syndromeHeart rateClinical implicationsFirst yearBeta-blocker therapyHigh-risk subsetInternational LQTS RegistryBeats/minAge 1 yearYears of lifeHazard ratioCardiac deathSyncopal episodesCardiac arrestLQTS RegistryFemale sexPrognostic aspectsQT intervalStudy populationHigh riskPatientsSyndrome