2017
APOE genotype and early &bgr;-amyloid accumulation in older adults without dementia
Lim Y, Mormino E, Weiner M, Aisen P, Weiner M, Aisen P, Petersen R, Jack C, Jagust W, Trojanowki J, Toga A, Beckett L, Green R, Saykin A, Morris J, Liu E, Green R, Montine T, Petersen R, Aisen P, Gamst A, Thomas R, Donohue M, Walter S, Gessert D, Sather T, Beckett L, Harvey D, Gamst A, Donohue M, Kornak J, Jack C, Dale A, Bernstein M, Felmlee J, Fox N, Thompson P, Schuff N, Alexander G, DeCarli C, Jagust W, Bandy D, Koeppe R, Foster N, Reiman E, Chen K, Mathis C, Morris J, Cairns N, Taylor-Reinwald L, Trojanowki J, Shaw L, Lee V, Korecka M, Toga A, Crawford K, Neu S, Saykin A, Foroud T, Potkin S, Shen L, Kachaturian Z, Frank R, Snyder P, Molchan S, Kaye J, Quinn J, Lind B, Dolen S, Schneider L, Pawluczyk S, Spann B, Brewer J, Vanderswag H, Heidebrink J, Lord J, Petersen R, Johnson K, Doody R, Villanueva-Meyer J, Chowdhury M, Stern Y, Honig L, Bell K, Morris J, Ances B, Carroll M, Leon S, Mintun M, Schneider S, Marson D, Griffith R, Clark D, Grossman H, Mitsis E, Romirowsky A, deToledo-Morrell L, Shah R, Duara R, Varon D, Roberts P, Albert M, Onyike C, Kielb S, Rusinek H, de Leon M, Glodzik L, De Santi S, Doraiswamy P, Petrella J, Coleman R, Arnold S, Karlawish J, Wolk D, Smith C, Jicha G, Hardy P, Lopez O, Oakley M, Simpson D, Porsteinsson A, Goldstein B, Martin K, Makino K, Ismail M, Brand C, Mulnard R, Thai G, McAdams-Ortiz C, Womack K, Mathews D, Quiceno M, Diaz-Arrastia R, King R, Weiner M, Martin-Cook K, DeVous M, Levey A, Lah J, Cellar J, Burns J, Anderson H, Swerdlow R, Apostolova L, Lu P, Bartzokis G, Silverman D, Graff-Radford, MBBCH N, Parfitt F, Johnson H, Farlow M, Hake A, Matthews B, Herring S, van Dyck C, Carson R, MacAvoy M, Chertkow H, Bergman H, Hosein C, Black S, Stefanovic B, Caldwell C, Robin Hsiung G, Feldman H, Mudge B, Assaly M, Kertesz A, Rogers J, Trost D, Bernick C, Munic D, Kerwin D, Mesulam M, Lipowski K, Wu C, Johnson N, Sadowsky C, Martinez W, Villena T, Turner R, Johnson K, Reynolds B, Sperling R, Johnson K, Marshall G, Frey M, Yesavage J, Taylor J, Lane B, Rosen A, Tinklenberg J, Sabbagh M, Belden C, Jacobson S, Kowall N, Killiany R, Budson A, Norbash A, Johnson P, Obisesan T, Wolday S, Bwayo S, Lerner A, Hudson L, Ogrocki P, Fletcher E, Carmichael O, Olichney J, DeCarli C, Kittur S, Borrie M, Lee T, Bartha D, Johnson S, Asthana S, Carlsson C, Potkin S, Preda A, Nguyen D, Tariot P, Fleisher A, Reeder S, Bates V, Capote H, Rainka M, Scharre D, Kataki M, Zimmerman E, Celmins D, Brown A, Pearlson G, Blank K, Anderson K, Saykin A, Santulli R, Schwartz E, Sink K, Williamson J, Garg P, Watkins F, Ott B, Querfurth H, Tremont G, Salloway S, Malloy P, Correia S, Rosen H, Miller B, Mintzer J, Longmire C, Spicer K, Finger E, Rachinsky I, Rogers J, Kertesz A, Drost D, Pomara N, Hernando R, Sarrael A, Schultz S, Boles Ponto L, Shim H, Smith K, Relkin N, Chaing G, Raudin L, Smith A, Fargher K, Raj B. APOE genotype and early &bgr;-amyloid accumulation in older adults without dementia. Neurology 2017, 89: 1028-1034. PMID: 28794245, PMCID: PMC5589795, DOI: 10.1212/wnl.0000000000004336.Peer-Reviewed Original ResearchConceptsLongitudinal Aβ accumulationAβ accumulationAβ groupOlder ageOlder adultsPrimary prevention trialsΒ-amyloid accumulationInfluence of agePrevention trialsAmyloid accumulationΕ4 carriageFlorbetapir PETΕ4 alleleHigh riskChronologic ageLongitudinal accumulationAbnormal levelsLongitudinal rateDementiaLinear mixed modelsAgeHigh rateΕ4AβAdults
2010
Apolipoprotein E (APOE) genotype has dissociable effects on memory and attentional–executive network function in Alzheimer’s disease
Wolk D, Dickerson B, Weiner M, Aiello M, Aisen P, Albert M, Alexander G, Anderson H, Anderson K, Apostolova L, Arnold S, Ashford W, Assaly M, Asthana S, Bandy D, Bartha R, Bates V, Beckett L, Bell K, Benincasa A, Bergman H, Bernick C, Bernstein M, Black S, Blank K, Borrie M, Brand C, Brewer J, Brown A, Burns J, Cairns N, Caldwell C, Capote H, Carlsson C, Carmichael O, Cellar J, Celmins D, Chen K, Chertkow H, Chowdhury M, Clark D, Connor D, Correia S, Crawford K, Dale A, de Leon M, De Santi S, DeCarli C, deToledo-Morrell L, DeVous M, Diaz-Arrastia R, Dolen S, Donohue M, Doody R, Doraiswamy P, Duara R, Englert J, Farlow M, Feldman H, Felmlee J, Fleisher A, Fletcher E, Foroud T, Foster N, Fox N, Frank R, Gamst A, Given C, Graff-Radford N, Green R, Griffith R, Grossman H, Hake A, Hardy P, Harvey D, Heidebrink J, Hendin B, Herring S, Honig L, Hosein C, Hsiung G, Hudson L, Ismail M, Jack C, Jacobson S, Jagust W, Jayam-Trouth A, Johnson K, Johnson H, Johnson N, Johnson K, Johnson K, Johnson S, Kachaturian Z, Karlawish J, Kataki M, Kaye J, Kertesz A, Killiany R, Kittur S, Koeppe R, Korecka M, Kornak J, Kozauer N, Lah J, Laubinger M, Lee V, Lee T, Lerner A, Levey A, Longmire C, Lopez O, Lord J, Lu P, MacAvoy M, Malloy P, Marson D, Martin-Cook K, Martinez W, Marzloff G, Mathis C, Mc-Adams-Ortiz C, Mesulam M, Miller B, Mintun M, Mintzer J, Molchan S, Montine T, Morris J, Mulnard R, Munic D, Nair A, Neu S, Nguyen D, Norbash A, Oakley M, Obisesan T, Ogrocki P, Ott B, Parfitt F, Pawluczyk S, Pearlson G, Petersen R, Petrella J, Potkin S, Potter W, Preda A, Quinn J, Rainka M, Reeder S, Reiman E, Rentz D, Reynolds B, Richard J, Roberts P, Rogers J, Rosen A, Rosen H, Rusinek H, Sabbagh M, Sadowsky C, Salloway S, Santulli R, Saykin A, Scharre D, Schneider L, Schneider S, Schuff N, Shah R, Shaw L, Shen L, Silverman D, Simpson D, Sink K, Smith C, Snyder P, Spann B, Sperling R, Spicer K, Stefanovic B, Stern Y, Stopa E, Tang C, Tariot P, Taylor-Reinwald L, Thai G, Thomas R, Thompson P, Tinklenberg J, Toga A, Tremont G, Trojanowki J, Trost D, Turner R, van Dyck C, Vanderswag H, Varon D, Villanueva-Meyer J, Villena T, Walter S, Wang P, Watkins F, Weiner M, Williamson J, Wolk D, Wu C, Zerrate M, Zimmerman. E. Apolipoprotein E (APOE) genotype has dissociable effects on memory and attentional–executive network function in Alzheimer’s disease. Proceedings Of The National Academy Of Sciences Of The United States Of America 2010, 107: 10256-10261. PMID: 20479234, PMCID: PMC2890481, DOI: 10.1073/pnas.1001412107.Peer-Reviewed Original ResearchConceptsMedial temporal lobe pathologyLarge-scale brain networksParticular cognitive domainsDomains of cognitionSpecific large-scale brain networksTemporal lobe pathologyDisease Neuroimaging InitiativeMild Alzheimer's diseaseExecutive controlLexical accessCognitive processesCognitive dissociationCognitive domainsDissociable effectsRegional cortical atrophyPoor memoryNeuroanatomic findingsPerformance deficitsMemory retentionBrain networksPotential confoundsCortical networksPsychometric testsRegional brain atrophyGreater impairment