2018
Identification of genetic risk factors in the Chinese population implicates a role of immune system in Alzheimer’s disease pathogenesis
Zhou X, Chen Y, Mok K, Zhao Q, Chen K, Chen Y, Hardy J, Li Y, Fu A, Guo Q, Ip N, Saykin A, Toga A, Borowski B, Ward C, DeCarli C, Mathis C, Jack C, Harvey D, Holtzman D, Jones D, Gessert D, Lilly E, Reiman E, Franklin E, Hefti F, Sorensen G, Jimenez G, Fillit H, Gunter J, Salazar J, Hsiao J, Morris J, Trojanowki J, Neu K, Kantarci K, Faber K, Harless K, Chen K, Nho K, Beckett L, Thal L, Thal L, Shaw L, Kuller L, Shen L, Hergesheimer L, Taylor-Reinwald L, Mesulam M, Korecka M, Raichle M, Carrillo M, Albert M, Senjem M, Bernstein M, Donohue M, Weiner M, Figurski M, Buckholtz N, Fox N, Cairns N, Schuff N, Foster N, Aisen P, Thompson P, Davies P, Snyder P, Snyder P, Vemuri P, Frank R, Koeppe R, Green R, Petersen R, Walter S, Paul S, Potkin S, Kim S, Foroud T, Montine T, Lee V, Jagust W, Potter W, Cabrera Y, Khachaturian Z, Fleisher A, Pierce A, Mintz A, Lerner A, Norbash A, Levey A, Rosen A, Smith A, Ulysse A, Budson A, Kertesz A, Oliver A, Hake A, Burke A, Sarrael A, Porsteinsson A, Lamb A, Lee A, Raj B, Lane B, Yanez B, Ances B, Mudge B, Lind B, Stefanovic B, Goldstein B, Bonakdarpour B, Matthews B, Ott B, Reynolds B, Miller B, Spann B, Sadowsky C, Bernick C, Smith C, Onyike C, Heyn C, Hosein C, Leach C, Belden C, van Dyck C, Clark C, Wu C, Albers C, Brand C, Bodge C, Tatsuoka C, Carlsson C, Mathews D, D’Agostino D, Silverman D, Marson D, Wolk D, Bachman D, Clark D, Geldmacher D, Hart D, Knopman D, Perry D, Winkfield D, Miller D, Kerwin D, Drost D, Simpson D, Munic D, Scharre D, Bartha R, Celmins D, Zimmerman E, Teng E, Coleman E, Zamrini E, Mitsis E, Finger E, Oates E, Sosa E, Woo E, Rogalski E, Fletcher E, Parfitt F, Thai G, Marshall G, Conrad G, Tremont G, Bartzokis G, Hsiung G, Chiang G, Pearlson G, Jicha G, Vanderswag H, Grossman H, Capote H, Bergman H, Chertkow H, Feldman H, Rosen H, Koleva H, Shim H, Rachinsky I, Mintzer J, Ziolkowski J, Brewer J, Lah J, Singleton-Garvin J, Cellar J, Brosch J, Tinklenberg J, Karlawish J, Villanueva-Meyer J, Kaye J, Burns J, Petrella J, Yesavage J, Allard J, Lord J, Hetelle J, Brockington J, Morris J, Olichney J, Rogers J, Quinn J, Kass J, Taylor J, Heidebrink J, Anderson K, Blank K, Smith K, Bell K, Johnson K, Tingus K, DeMarco K, Sink K, Johnson K, Makino K, Spicer K, Nam K, Martin K, Poki-Walker K, Johnson K, Fargher K, Lipowski K, Womack K, Flashman L, Honig L, Apostolova L, Teodoro L, Silbert L, Ravdin L, Schneider L, Daiello L, Ismail M, Seltzer M, Mesulam M, Carroll M, Kataki M, Greig-Custo M, Love M, Mintun M, Farlow M, Sadowski M, Creech M, Hynes M, Quiceno M, Oakley M, Becerra M, Witbracht M, Keltz M, Lamar M, Yang M, Borrie M, Lin M, Assaly M, Rainka M, Dang M, Sheikh M, Gaikwad M, Chowdhury M, Trncic N, Johnson N, Kowalksi N, Pacini N, Kowall N, Graff-Radford N, Relkin N, Oyonumo N, Pomara N, James O, Ogunlana O, Lopez O, Carmichael O, Doraiswamy P, Fatica P, Johnson P, Samuels P, Malloy P, Ogrocki P, Maillard P, Hardy P, Tariot P, Lu P, Varma P, Doody R, Carter R, Shah R, Griffith R, Yeh R, Duara R, Tarawneh R, Turner R, Hernando R, Sperling R, Carson R, El Khouli R, Santulli R, Killiany R, Rodriguez R, Swerdlow R, Borges-Neto S, Black S, Weintraub S, Asthana S, Vaishnavi S, Dolen S, Mason S, Kremen S, Herring S, Sirrel S, Kittur S, Pawluczyk S, Schneider S, Kielb S, Reeder S, Correia S, Pasternack S, Pasternak S, Salloway S, Johnson S, Chao S, Arnold S, Schultz S, Rountree S, Lee T, Wong T, Villena T, Obisesan T, Pavlik V, Bates V, Sossi V, Shibley V, Brooks W, Pavlosky W, Stern Y, Simon A, Dongre A, Dean B, Navia B, Spellman D, Lee D, Shera D, Siemers E, Pickering E, Swenson F, Immerman F, Nomikos G, Soares H, Wan H, Seeburger J, Waring J, Trojanowski J, Siuciak J, Duffin K, Shaw L, Wang L, Thambisetty M, Walton M, Savage M, Ferm M, Kuhn M, Buckholtz N, Zagouras P, Cole P, Hendrickson R, Xie S, Allauzen S, Koroshetz W, Potter W. Identification of genetic risk factors in the Chinese population implicates a role of immune system in Alzheimer’s disease pathogenesis. Proceedings Of The National Academy Of Sciences Of The United States Of America 2018, 115: 1697-1706. PMID: 29432188, PMCID: PMC5828602, DOI: 10.1073/pnas.1715554115.Peer-Reviewed Original ResearchConceptsAlzheimer's diseaseChinese populationAD subjectsDisease pathogenesisImmune systemPlasma biomarker levelsEarly disease onsetMinor allele carriersAlzheimer's disease (AD) pathogenesisGenetic risk factorsImmune-related pathwaysCommon variantsGenotype-phenotype analysisDisease onsetRisk factorsBiomarker levelsLeading causeOnset ageAllele carriersAD riskAD cohortPossible risk effectsFunctional effectsExpression levelsRegulatory effects
2017
APOE genotype and early &bgr;-amyloid accumulation in older adults without dementia
Lim Y, Mormino E, Weiner M, Aisen P, Weiner M, Aisen P, Petersen R, Jack C, Jagust W, Trojanowki J, Toga A, Beckett L, Green R, Saykin A, Morris J, Liu E, Green R, Montine T, Petersen R, Aisen P, Gamst A, Thomas R, Donohue M, Walter S, Gessert D, Sather T, Beckett L, Harvey D, Gamst A, Donohue M, Kornak J, Jack C, Dale A, Bernstein M, Felmlee J, Fox N, Thompson P, Schuff N, Alexander G, DeCarli C, Jagust W, Bandy D, Koeppe R, Foster N, Reiman E, Chen K, Mathis C, Morris J, Cairns N, Taylor-Reinwald L, Trojanowki J, Shaw L, Lee V, Korecka M, Toga A, Crawford K, Neu S, Saykin A, Foroud T, Potkin S, Shen L, Kachaturian Z, Frank R, Snyder P, Molchan S, Kaye J, Quinn J, Lind B, Dolen S, Schneider L, Pawluczyk S, Spann B, Brewer J, Vanderswag H, Heidebrink J, Lord J, Petersen R, Johnson K, Doody R, Villanueva-Meyer J, Chowdhury M, Stern Y, Honig L, Bell K, Morris J, Ances B, Carroll M, Leon S, Mintun M, Schneider S, Marson D, Griffith R, Clark D, Grossman H, Mitsis E, Romirowsky A, deToledo-Morrell L, Shah R, Duara R, Varon D, Roberts P, Albert M, Onyike C, Kielb S, Rusinek H, de Leon M, Glodzik L, De Santi S, Doraiswamy P, Petrella J, Coleman R, Arnold S, Karlawish J, Wolk D, Smith C, Jicha G, Hardy P, Lopez O, Oakley M, Simpson D, Porsteinsson A, Goldstein B, Martin K, Makino K, Ismail M, Brand C, Mulnard R, Thai G, McAdams-Ortiz C, Womack K, Mathews D, Quiceno M, Diaz-Arrastia R, King R, Weiner M, Martin-Cook K, DeVous M, Levey A, Lah J, Cellar J, Burns J, Anderson H, Swerdlow R, Apostolova L, Lu P, Bartzokis G, Silverman D, Graff-Radford, MBBCH N, Parfitt F, Johnson H, Farlow M, Hake A, Matthews B, Herring S, van Dyck C, Carson R, MacAvoy M, Chertkow H, Bergman H, Hosein C, Black S, Stefanovic B, Caldwell C, Robin Hsiung G, Feldman H, Mudge B, Assaly M, Kertesz A, Rogers J, Trost D, Bernick C, Munic D, Kerwin D, Mesulam M, Lipowski K, Wu C, Johnson N, Sadowsky C, Martinez W, Villena T, Turner R, Johnson K, Reynolds B, Sperling R, Johnson K, Marshall G, Frey M, Yesavage J, Taylor J, Lane B, Rosen A, Tinklenberg J, Sabbagh M, Belden C, Jacobson S, Kowall N, Killiany R, Budson A, Norbash A, Johnson P, Obisesan T, Wolday S, Bwayo S, Lerner A, Hudson L, Ogrocki P, Fletcher E, Carmichael O, Olichney J, DeCarli C, Kittur S, Borrie M, Lee T, Bartha D, Johnson S, Asthana S, Carlsson C, Potkin S, Preda A, Nguyen D, Tariot P, Fleisher A, Reeder S, Bates V, Capote H, Rainka M, Scharre D, Kataki M, Zimmerman E, Celmins D, Brown A, Pearlson G, Blank K, Anderson K, Saykin A, Santulli R, Schwartz E, Sink K, Williamson J, Garg P, Watkins F, Ott B, Querfurth H, Tremont G, Salloway S, Malloy P, Correia S, Rosen H, Miller B, Mintzer J, Longmire C, Spicer K, Finger E, Rachinsky I, Rogers J, Kertesz A, Drost D, Pomara N, Hernando R, Sarrael A, Schultz S, Boles Ponto L, Shim H, Smith K, Relkin N, Chaing G, Raudin L, Smith A, Fargher K, Raj B. APOE genotype and early &bgr;-amyloid accumulation in older adults without dementia. Neurology 2017, 89: 1028-1034. PMID: 28794245, PMCID: PMC5589795, DOI: 10.1212/wnl.0000000000004336.Peer-Reviewed Original ResearchConceptsLongitudinal Aβ accumulationAβ accumulationAβ groupOlder ageOlder adultsPrimary prevention trialsΒ-amyloid accumulationInfluence of agePrevention trialsAmyloid accumulationΕ4 carriageFlorbetapir PETΕ4 alleleHigh riskChronologic ageLongitudinal accumulationAbnormal levelsLongitudinal rateDementiaLinear mixed modelsAgeHigh rateΕ4AβAdults
2016
Bayesian model reveals latent atrophy factors with dissociable cognitive trajectories in Alzheimer’s disease
Zhang X, Mormino E, Sun N, Sperling R, Sabuncu M, Yeo B, Weiner M, Aisen P, Weiner M, Aisen P, Petersen R, Jack C, Jagust W, Trojanowki J, Toga A, Beckett L, Green R, Saykin A, Morris J, Shaw L, Khachaturian Z, Sorensen G, Carrillo M, Kuller L, Raichle M, Paul S, Davies P, Fillit H, Hefti F, Holtzman D, Mesulam M, Potter W, Snyder P, Schwartz A, Green R, Montine T, Petersen R, Aisen P, Thomas R, Donohue M, Walter S, Gessert D, Sather T, Jiminez G, Balasubramanian A, Mason J, Sim I, Beckett L, Harvey D, Donohue M, Jack C, Bernstein M, Fox N, Thompson P, Schuff N, DeCArli C, Borowski D, Gunter J, Senjem M, Vemuri P, Jones D, Kantarci K, Ward C, Jagust W, Koeppe R, Foster N, Reiman E, Chen K, Mathis C, Landau S, Morris J, Cairns N, Franklin E, Taylor-Reinwald L, Shaw L, Trojanowki J, Lee V, Korecka M, Figurski M, Toga A, Crawford K, Neu S, Saykin A, Foroud T, Potkin S, Shen L, Faber K, Kim S, Nho K, Weiner M, Thal L, Khachaturian Z, Thal L, Buckholtz N, Weiner M, Snyder P, Potter W, Paul S, Albert M, Frank R, Khachaturian Z, Hsiao J, Kaye J, Quinn J, Silbert L, Lind B, Carter R, Dolen S, Schneider L, Pawluczyk S, Becerra M, Teodoro L, Spann B, Brewer J, Vanderswag H, Fleisher A, Heidebrink J, Lord J, Petersen R, Mason S, Albers C, Knopman D, Johnson K, Doody R, Villanueva-Meyer J, Pavlik V, Shibley V, Chowdhury M, Rountree S, Dang M, Stern Y, Honig L, Bell K, Ances B, Morris J, Carroll M, Creech M, Franklin E, Mintun M, Schneider S, Oliver A, Marson D, Geldmacher D, Love M, Griffith R, Clark D, Brockington J, Roberson E, Grossman H, Mitsis E, Shah R, deToledo-Morrell L, Duara R, Greig-Custo M, Barker W, Albert M, Onyike C, D’Agostino D, Kielb S, Sadowski M, Sheikh M, Ulysse A, Gaikwad M, Doraiswamy P, Petrella J, Borges-Neto S, Wong T, Coleman E, Arnold S, Karlawish J, Wolk D, Clark C, Smith C, Jicha G, Hardy P, Sinha P, Oates E, Conrad G, Lopez O, Oakley M, Simpson D, Porsteinsson A, Goldstein B, Martin K, Makino K, Ismail M, Brand C, Potkin S, Preda A, Nguyen D, Womack K, Mathews D, Quiceno M, Levey A, Lah J, Cellar J, Burns J, Swerdlow R, Brooks W, Apostolova L, Tingus K, Woo E, Silverman D, Lu P, Bartzokis G, Graff-Radford N, Parfitt F, Poki-Walker K, Farlow M, Hake A, Matthews B, Brosch J, Herring S, van Dyck C, Carson R, MacAvoy M, Varma P, Chertkow H, Bergman H, Hosein C, Black S, Stefanovic B, Caldwell C, Hsiung G, Mudge B, Sossi V, Feldman H, Assaly M, Finger E, Pasternack S, Rachisky I, Trost D, Kertesz A, Bernick C, Munic D, Mesulam M, Rogalski E, Lipowski K, Weintraub S, Bonakdarpour B, Kerwin D, Wu C, Johnson N, Sadowsky C, Villena T, Turner R, Johnson K, Reynolds B, Sperling R, Johnson K, Marshall G, Yesavage J, Taylor J, Lane B, Rosen A, Tinklenberg J, Sabbagh M, Belden C, Jacobson S, Sirrel S, Kowall N, Killiany R, Budson A, Norbash A, Johnson P, Obisesan T, Wolday S, Allard J, Lerner A, Ogrocki P, Tatsuoka C, Fatica P, Fletcher E, Maillard P, Olichney J, DeCarli C, Carmichael O, Kittur S, Borrie M, Lee T, Bartha R, Johnson S, Asthana S, Carlsson C, Potkin S, Preda A, Nguyen D, Tariot P, Burke A, Milliken A, Trncic N, Fleisher A, Reeder S, Bates V, Capote H, Rainka M, Scharre D, Kataki M, Kelley B, Zimmerman E, Celmins D, Brown A, Pearlson G, Blank K, Anderson K, Flashman L, Seltzer M, Hynes M, Santulli R, Sink K, Gordineer L, Williamson J, Garg P, Watkins F, Ott B, Tremont G, Daiello L, Salloway S, Malloy P, Correia S, Rosen H, Miller B, Perry D, Mintzer J, Spicer K, Bachman D, Finger E, Pasternak S, Rachinsky I, Rogers J, Kertesz A, Drost D, Pomara N, Hernando R, Sarrael A, Schultz S, Smith K, Koleva H, Nam K, Shim H, Relkin N, Chiang G, Lin M, Ravdin L, Smith A, Raj B, Fargher K. Bayesian model reveals latent atrophy factors with dissociable cognitive trajectories in Alzheimer’s disease. Proceedings Of The National Academy Of Sciences Of The United States Of America 2016, 113: e6535-e6544. PMID: 27702899, PMCID: PMC5081632, DOI: 10.1073/pnas.1611073113.Peer-Reviewed Original ResearchConceptsAtrophy factorAtrophy patternsCortical factorsDementia patientsAlzheimer's disease dementia patientsDistinct atrophy patternsStrong associationEntire clinical spectrumAD dementia patientsExecutive function declineExecutive functionSubcortical factorsFunction declineClinical spectrumEarly ADAlzheimer's diseaseStructural MRIDisease monitoringNormal participantsMemory declineMCI participantsDifferent cognitive domainsPatientsFactor compositionCognitive trajectories
2014
Multivariate analysis reveals genetic associations of the resting default mode network in psychotic bipolar disorder and schizophrenia
Meda SA, Ruaño G, Windemuth A, O’Neil K, Berwise C, Dunn SM, Boccaccio LE, Narayanan B, Kocherla M, Sprooten E, Keshavan MS, Tamminga CA, Sweeney JA, Clementz BA, Calhoun VD, Pearlson GD. Multivariate analysis reveals genetic associations of the resting default mode network in psychotic bipolar disorder and schizophrenia. Proceedings Of The National Academy Of Sciences Of The United States Of America 2014, 111: e2066-e2075. PMID: 24778245, PMCID: PMC4024891, DOI: 10.1073/pnas.1313093111.Peer-Reviewed Original ResearchConceptsDefault mode networkPsychotic bipolar disorderUnaffected first-degree relativesFirst-degree relativesSZ probandsResting-state functional MRI scansBipolar disorderMode networkFunctional MRI scansLong-term potentiationBrain's default mode networkGlobal enrichment analysisSubset of controlsPatient groupHealthy controlsDMN modulationDrug treatmentImmune responsePsychiatric disordersStudy subjectsMRI scansDMN connectivityMultivariate analysisFunctional connectivitySchizophrenia
2010
A commonly carried allele of the obesity-related FTO gene is associated with reduced brain volume in the healthy elderly
Ho A, Stein J, Hua X, Lee S, Hibar D, Leow A, Dinov I, Toga A, Saykin A, Shen L, Foroud T, Pankratz N, Huentelman M, Craig D, Gerber J, Allen A, Corneveaux J, Stephan D, DeCarli C, DeChairo B, Potkin S, Jack C, Weiner M, Raji C, Lopez O, Becker J, Carmichael O, Thompson P, Weiner M, Thal L, Petersen R, Jack C, Jagust W, Trojanowki J, Toga A, Beckett L, Green R, Gamst A, Potter W, Montine T, Anders D, Bernstein M, Felmlee J, Fox N, Thompson P, Schuff N, Alexander G, Bandy D, Koeppe R, Foster N, Reiman E, Chen K, Trojanowki J, Shaw L, Lee V, Korecka M, Toga A, Crawford K, Neu S, Harvey D, Gamst A, Kornak J, Kachaturian Z, Frank R, Snyder P, Molchan S, Kaye J, Vorobik R, Quinn J, Schneider L, Pawluczyk S, Spann B, Fleisher A, Vanderswag H, Heidebrink J, Lord J, Johnson K, Doody R, Villanueva-Meyer J, Chowdhury M, Stern Y, Honig L, Bell K, Morris J, Mintun M, Schneider S, Marson D, Griffith R, Badger B, Grossman H, Tang C, Stern J, deToledo-Morrell L, Shah R, Bach J, Duara R, Isaacson R, Strauman S, Albert M, Pedroso J, Toroney J, Rusinek H, de Leon M, De Santi S, Doraiswamy P, Petrella J, Aiello M, Clark C, Pham C, Nunez J, Smith C, Given C, Hardy P, DeKosky S, Oakley M, Simpson D, Ismail M, Porsteinsson A, McCallum C, Cramer S, Mulnard R, McAdams-Ortiz C, Diaz-Arrastia R, Martin-Cook K, DeVous M, Levey A, Lah J, Cellar J, Burns J, Anderson H, Laubinger M, Bartzokis G, Silverman D, Lu P, Fletcher R, Parfitt F, Johnson H, Farlow M, Herring S, Hake A, van Dyck C, MacAvoy M, Bifano L, Chertkow H, Bergman H, Hosein C, Black S, Graham S, Caldwell C, Feldman H, Assaly M, Hsiung G, Kertesz A, Rogers J, Trost D, Bernick C, Gitelman D, Johnson N, Mesulam M, Sadowsky C, Villena T, Mesner S, Aisen P, Johnson K, Behan K, Sperling R, Rentz D, Johnson K, Rosen A, Tinklenberg J, Ashford W, Sabbagh M, Connor D, Obradov S, Killiany R, Norbash A, Obisesan T, Jayam-Trouth A, Wang P, Auchus A, Huang J, Friedland R, DeCarli C, Fletcher E, Carmichael O, Kittur S, Mirje S, Johnson S, Borrie M, Lee T, Asthana S, Carlsson C, Potkin S, Highum D, Preda A, Nguyen D, Tariot P, Hendin B, Scharre D, Kataki M, Beversdorf D, Zimmerman E, Celmins D, Brown A, Gandy S, Marenberg M, Rovner B, Pearlson G, Blank K, Anderson K, Saykin A, Santulli R, Pare N, Williamson J, Sink K, Potter H, Raj B, Giordano A, Ott B, Wu C, Cohen R, Wilks K. A commonly carried allele of the obesity-related FTO gene is associated with reduced brain volume in the healthy elderly. Proceedings Of The National Academy Of Sciences Of The United States Of America 2010, 107: 8404-8409. PMID: 20404173, PMCID: PMC2889537, DOI: 10.1073/pnas.0910878107.Peer-Reviewed Original ResearchConceptsBody mass indexRisk allele carriersBrain volume differencesBrain atrophyDisease Neuroimaging InitiativeAllele carriersVolume deficitsElevated body mass indexHigher body mass indexRisk allelesSignificant volume deficitsStructural brain atrophyRegional brain volume differencesBrain volume deficitsGreater waist circumferenceReduced brain volumeHealthy elderly subjectsWhite matter hyperintensitiesObesity-associated (FTO) geneAlzheimer's Disease Neuroimaging InitiativeWaist circumferenceMass indexVolume differencesCholesterol levelsObese persons
1988
The Late-Onset Psychoses Possible Risk Factors
Pearlson G, Rabins P. The Late-Onset Psychoses Possible Risk Factors. Psychiatric Clinics Of North America 1988, 11: 15-32. PMID: 3288978, DOI: 10.1016/s0193-953x(18)30514-8.Peer-Reviewed Original Research