2021
Tau‐Atrophy Variability Reveals Phenotypic Heterogeneity in Alzheimer's Disease
Das S, Lyu X, Duong M, Xie L, McCollum L, Flores R, DiCalogero M, Irwin D, Dickerson B, Nasrallah I, Yushkevich P, Wolk D, Weiner M, Aisen P, Petersen R, Jack C, Jagust W, Trojanowki J, Toga A, Beckett L, Green R, Saykin A, Morris J, Shaw L, Liu E, Montine T, Thomas R, Donohue M, Walter S, Gessert D, Sather T, Jiminez G, Harvey D, Donohue M, Bernstein M, Fox N, Thompson P, Schuff N, DeCArli C, Borowski B, Gunter J, Senjem M, Vemuri P, Jones D, Kantarci K, Ward C, Koeppe R, Foster N, Reiman E, Chen K, Mathis C, Landau S, Cairns N, Householder E, Reinwald L, Lee V, Korecka M, Figurski M, Crawford K, Neu S, Foroud T, Potkin S, Shen L, Kelley F, Kim S, Nho K, Kachaturian Z, Frank R, Snyder P, Molchan S, Kaye J, Quinn J, Lind B, Carter R, Dolen S, Schneider L, Pawluczyk S, Beccera M, Teodoro L, Spann B, Brewer J, Vanderswag H, Fleisher A, Heidebrink J, Lord J, Petersen R, Mason S, Albers C, Knopman D, Johnson K, Doody R, Meyer J, Chowdhury M, Rountree S, Dang M, Stern Y, Honig L, Bell K, Ances B, Morris J, Carroll M, Leon S, Householder E, Mintun M, Schneider S, Oliver A, Marson D, Griffith R, Clark D, Geld‐Macher D, Brockington J, Roberson E, Grossman H, Mitsis E, Toledo‐Morrell L, Shah R, Duara R, Varon D, Greig M, Roberts P, Albert M, Onyike C, D'Agostino D, Kielb S, Galvin J, Pogorelec D, Cerbone B, Michel C, Rusinek H, Leon M, Glodzik L, De Santi S, Doraiswamy P, Petrella J, Wong T, Arnold S, Karlawish J, Wolk D, Smith C, Jicha G, Hardy P, Sinha P, Oates E, Conrad G, Lopez O, Oakley M, Simpson D, Porsteinsson A, Goldstein B, Martin K, Makino K, Ismail M, Brand C, Mulnard R, Thai G, Ortiz C, Womack K, Mathers D, Quiceno M, Arrastia R, King R, Weiner M, Martin Cook K, DeVous M, Levey A, Lah J, Cellar J, Bums J, Anderson H, Swerdlow R, Apostolova L, Tingus K, Woo E, Silverman D, Lu P, Bartzokis G, Graff Radford N, Parfitt F, Kendall T, Johnson H, Farlow M, Hake A, Matthews B, Herring S, Hunt C, Dyck C, Carson R, MacAvoy M, Chertkow H, Bergman H, Hosein C, Black S, Stefanovic B, Caldwell C, Hsiung G, Feldman H, Mudge B, Assaly M, Kertesz A, Rogers J, Trost D, Bernick C, Munic D, Kerwin D, Mesulam M, Lipowski K, Wu C, Johnson N, Sadowsky C, Martinez W, Villena T, Turner R, Kathleen Johnson N, Brigid Reynolds N, Sperling R, Johnson K, Marshall G, Frey M, Yesavage J, Taylor J, Lane B, Rosen A, Tinklenberg J, Sabbagh M, Belden C, Jacobson S, Sirrel S, Kowall N, Killiany R, Budson A, Norbash A, Johnson P, Obisesan T, Wolday S, Allard J, Lerner A, Ogrocki P, Hudson L, Fletcher E, Carmichael O, Olichney J, DeCarli C, Kittur S, Borrie M, Lee T, Bartha R, Johnson S, Asthana S, Carlsson C, Potkin S, Preda A, Nguyen D, Tariot P, Fleisher A, Reeder S, Bates V, Capote H, Rainka M, Scharre D, Kataki M, Adeli A, Zimmerman E, Celmins D, Brown A, Pearlson G, Blank K, Anderson K, Santulli R, Kitzmiller T, Schwartz E, Sink K, Williamson J, Garg P, Watkins F, Ott B, Querfurth H, Tremont G, Salloway S, Malloy P, Correia S, Rosen H, Miller B, Mintzer J, Spicer K, Bachman D, Finger E, Pasternak S, Rachinsky I, Rogers J, Kertesz A, Drost D, Pomara N, Hernando R, Sarrael A, Schultz S, Boles Ponto L, Shim H, Smith K, Relkin N, Chaing G, Raudin L, Smith A, Fargher K, Raj B. Tau‐Atrophy Variability Reveals Phenotypic Heterogeneity in Alzheimer's Disease. Annals Of Neurology 2021, 90: 751-762. PMID: 34617306, PMCID: PMC8841129, DOI: 10.1002/ana.26233.Peer-Reviewed Original ResearchConceptsData-driven subgroupsAlzheimer's diseaseLow atrophyCortical thicknessBrain regionsWhite matter hyperintensity lesionsModulatory factorsAmyloid-positive individualsSubsequent cognitive impairmentLevels of tauGray matter regionsAnn NeurolDownstream neurodegenerationHyperintensity lesionsTau neurofibrillaryTau burdenClinical trialsCognitive impairmentMatter regionsDiseaseMultiple underlying factorsNeurodegenerationAtrophyCohortSUVR
2017
Conversion Discriminative Analysis on Mild Cognitive Impairment Using Multiple Cortical Features from MR Images
Guo S, Lai C, Wu C, Cen G, Initiative T, Weiner M, Aisen P, Weiner M, Aisen P, Petersen R, Jack C, Jagust W, Trojanowki J, Toga A, Beckett L, Green R, Saykin A, Morris J, Shaw L, Khachaturian Z, Sorensen G, Carrillo M, Kuller L, Raichle M, Paul S, Davies P, Fillit H, Hefti F, Holtzman D, Mesulam M, Potter W, Snyder P, Schwartz A, Green R, Montine T, Petersen R, Aisen P, Thomas R, Donohue M, Walter S, Gessert D, Sather T, Jiminez G, Balasubramanian A, Mason J, Sim I, Beckett L, Harvey D, Donohue M, Jack C, Bernstein M, Fox N, Thompson P, Schuff N, DeCArli C, Borowski B, Gunter J, Senjem M, Vemuri P, Jones D, Kantarci K, Ward C, Jagust W, Koeppe R, Foster N, Reiman E, Chen K, Mathis C, Landau S, Morris J, Cairns N, Franklin E, Taylor-Reinwald L, Shaw L, Trojanowki J, Lee V, Korecka M, Figurski M, Toga A, Crawford K, Neu S, Saykin A, Foroud T, Potkin S, Shen L, Faber K, Kim S, Nho K, Weiner M, Thal L, Khachaturian Z, Thal L, Buckholtz N, Weiner M, Snyder P, Potter W, Paul S, Albert M, Frank R, Khachaturian Z, Hsiao J, Kaye J, Quinn J, Silbert L, Lind B, Carter R, Dolen S, Schneider L, Pawluczyk S, Becerra M, Teodoro L, Spann B, Brewer J, Vanderswag H, Fleisher A, Heidebrink J, Lord J, Petersen R, Mason S, Albers C, Knopman D, Johnson K, Doody R, Villanueva-Meyer J, Pavlik V, Shibley V, Chowdhury M, Rountree S, Dang M, Stern Y, Honig L, Bell K, Ances B, Morris J, Carroll M, Creech M, Franklin E, Mintun M, Schneider S, Oliver A, Marson D, Geldmacher D, Love M, Griffith R, Clark D, Brockington J, Roberson E, Grossman H, Mitsis E, Shah R, deToledo-Morrell L, Duara R, Greig-Custo M, Barker W, Albert M, Onyike C, D'Agostino D, Kielb S, Sadowski M, Sheikh M, Anaztasia U, Mrunalini G, Doraiswamy P, Petrella J, Borges-Neto S, Wong T, Coleman E, Arnold S, Karlawish J, Wolk D, Clark C, Smith C, Jicha G, Hardy P, Sinha P, Oates E, Conrad G, Lopez O, Oakley M, Simpson D, Porsteinsson A, Goldstein B, Martin K, Makino K, Ismail M, Brand C, Potkin S, Preda A, Nguyen D, Womack K, Mathews D, Quiceno M, Levey A, Lah J, Cellar J, Burns J, Swerdlow R, Brooks W, Apostolova L, Tingus K, Woo E, Silverman D, Lu P, Bartzokis G, Graff-Radford N, Parfitt F, Poki-Walker K, Farlow M, Hake A, Matthews B, Brosch J, Herring S, van Dyck C, Carson R, MacAvoy M, Varma P, Chertkow H, Bergman H, Hosein C, Black S, Stefanovic B, Caldwell C, Hsiung G, Mudge B, Sossi V, Feldman H, Assaly M, Finger E, Pasternack S, Rachisky I, Trost D, Kertesz A, Bernick C, Munic D, Mesulam M, Rogalski E, Lipowski K, Weintraub S, Bonakdarpour B, Kerwin D, Wu C, Johnson N, Sadowsky C, Villena T, Turner R, Johnson K, Reynolds B, Sperling R, Johnson K, Marshall G, Yesavage J, Taylor J, Lane B, Rosen A, Tinklenberg J, Sabbagh M, Belden C, Jacobson S, Sirrel S, Kowall N, Killiany R, Budson A, Norbash A, Johnson P, Obisesan T, Wolday S, Allard J, Lerner A, Ogrocki P, Tatsuoka C, Fatica P, Fletcher E, Maillard P, Olichney J, DeCarli C, Carmichael O, Kittur S, Borrie M, Lee T, Bartha R, Johnson S, Asthana S, Carlsson C, Potkin S, Preda A, Nguyen D, Tariot P, Burke A, Milliken A, Trncic N, Fleisher A, Reeder S, Bates V, Capote H, Rainka M, Scharre D, Kataki M, Kelley B, Zimmerman E, Celmins D, Brown A, Pearlson G, Blank K, Anderson K, Flashman L, Seltzer M, Hynes M, Santulli R, Sink K, Leslie G, Williamson J, Garg P, Watkins F, Ott B, Tremont G, Daiello L, Salloway S, Malloy P, Correia S, Rosen H, Miller B, Perry D, Mintzer J, Spicer K, Bachman D, Finger E, Pasternak S, Rachinsky I, Rogers J, Kertesz A, Drost D, Pomara N, Hernando R, Sarrael A, Schultz S, Smith K, Koleva H, Nam K, Shim H, Relkin N, Chiang G, Lin M, Ravdin L, Smith A, Raj B, Fargher K, Weiner M, Aisen P, Weiner M, Aisen P, Petersen R, Green R, Harvey D, Jack C, Jagust W, Morris J, Saykin A, Shaw L, Toga A, Trojanowki J, Neylan T, Grafman J, Green R, Montine T, Weiner M, Petersen R, Aisen P, Thomas R, Donohue M, Devon G, Sather T, Melissa D, Morrison R, Jiminez G, Neylan T, Jacqueline H, Shannon F, Harvey D, Donohue M, Jack C, Bernstein M, Borowski B, Gunter J, Senjem M, Kejal K, Chad W, Jagust W, Koeppe R, Foster N, Reiman E, Chen K, Landau S, Morris J, Cairns N, Householder E, Shaw L, Trojanowki J, Lee V, Korecka M, Figurski M, Toga A, Karen C, Scott N, Saykin A, Foroud T, Potkin S, Shen L, Faber K, Kim S, Nho K, Weiner M, Karl F, Schneider L, Pawluczyk S, Mauricio B, Brewer J, Vanderswag H, Stern Y, Honig L, Bell K, Fleischman D, Arfanakis K, Shah R, Duara R, Varon D, Greig M, Doraiswamy P, Petrella J, James O, Porsteinsson A, Goldstein B, Martin K, Potkin S, Preda A, Nguyen D, Mintzer J, Massoglia D, Brawman-Mintzer O, Sadowsky C, Martinez W, Villena T, Jagust W, Landau S, Rosen H, Perry D, Turner R, Behan K, Reynolds B, Sperling R, Johnson K, Marshall G, Sabbagh M, Jacobson S, Sirrel S, Obisesan T, Wolday S, Allard J, Johnson S, Fruehling J, Harding S, Peskind E, Petrie E, Li G, Yesavage J, Taylor J, Furst A, Chao S, Relkin N, Chiang G, Ravdin L. Conversion Discriminative Analysis on Mild Cognitive Impairment Using Multiple Cortical Features from MR Images. Frontiers In Aging Neuroscience 2017, 9: 146. PMID: 28572766, PMCID: PMC5435825, DOI: 10.3389/fnagi.2017.00146.Peer-Reviewed Original ResearchMild cognitive impairmentCortical featuresDisease Neuroimaging InitiativeCortical thicknessCognitive impairmentAnatomical patternsStable mild cognitive impairmentNormal control groupGray matter volumeMagnetic resonance imagingAlzheimer's Disease Neuroimaging InitiativeMatter volumeControl groupMCI patientsAlzheimer's diseaseResonance imagingBrain regionsClinical diagnosisMultiple cortical featuresStable MCILongitudinal measurementsDiseaseImpairmentRegression modelsMR imagesAdding Recognition Discriminability Index to the Delayed Recall Is Useful to Predict Conversion from Mild Cognitive Impairment to Alzheimer's Disease in the Alzheimer's Disease Neuroimaging Initiative
Russo M, Campos J, Vázquez S, Sevlever G, Allegri R, Initiative T, Weiner M, Aisen P, Weiner M, Aisen P, Petersen R, Jack C, Jagust W, Trojanowki J, Toga A, Beckett L, Green R, Saykin A, Morris J, Shaw L, Khachaturian Z, Sorensen G, Carrillo M, Kuller L, Raichle M, Paul S, Davies P, Fillit H, Hefti F, Holtzman D, Mesulam M, Potter W, Snyder P, Schwartz A, Green R, Montine T, Petersen R, Aisen P, Thomas R, Donohue M, Walter S, Gessert D, Sather T, Jiminez G, Balasubramanian A, Mason J, Sim I, Beckett L, Harvey D, Donohue M, Jack C, Bernstein M, Fox N, Thompson P, Schuff N, DeCArli C, Borowski B, Gunter J, Senjem M, Vemuri P, Jones D, Kantarci K, Ward C, Jagust W, Koeppe R, Foster N, Reiman E, Chen K, Mathis C, Landau S, Morris J, Cairns N, Franklin E, Taylor-Reinwald L, Shaw L, Trojanowki J, Lee V, Korecka M, Figurski M, Toga A, Crawford K, Neu S, Saykin A, Foroud T, Potkin S, Shen L, Faber K, Kim S, Nho K, Weiner M, Thal L, Khachaturian Z, Thal L, Buckholtz N, Weiner M, Snyder P, Potter W, Paul S, Albert M, Frank R, Khachaturian Z, Hsiao J, Kaye J, Quinn J, Silbert L, Lind B, Carter R, Dolen S, Schneider L, Pawluczyk S, Becerra M, Teodoro L, Spann B, Brewer J, Vanderswag H, Fleisher A, Heidebrink J, Lord J, Petersen R, Mason S, Albers C, Knopman D, Johnson K, Doody R, Villanueva-Meyer J, Pavlik V, Shibley V, Chowdhury M, Rountree S, Dang M, Stern Y, Honig L, Bell K, Ances B, Morris J, Carroll M, Creech M, Franklin E, Mintun M, Schneider S, Oliver A, Marson D, Geldmacher D, Love M, Griffith R, Clark D, Brockington J, Roberson E, Grossman H, Mitsis E, Shah R, deToledo-Morrell L, Duara R, Greig-Custo M, Barker W, Albert M, Onyike C, D'Agostino D, Kielb S, Sadowski M, Sheikh M, Anaztasia U, Mrunalini G, Doraiswamy P, Petrella J, Borges-Neto S, Wong T, Coleman E, Arnold S, Karlawish J, Wolk D, Clark C, Smith C, Jicha G, Hardy P, Sinha P, Oates E, Conrad G, Lopez O, Oakley M, Simpson D, Porsteinsson A, Goldstein B, Martin K, Makino K, Ismail M, Brand C, Potkin S, Preda A, Nguyen D, Womack K, Mathews D, Quiceno M, Levey A, Lah J, Cellar J, Burns J, Swerdlow R, Brooks W, Apostolova L, Tingus K, Woo E, Silverman D, Lu P, Bartzokis G, Graff-Radford N, Parfitt F, Poki-Walker K, Farlow M, Hake A, Matthews B, Brosch J, Herring S, van Dyck C, Carson R, MacAvoy M, Varma P, Chertkow H, Bergman H, Hosein C, Black S, Stefanovic B, Caldwell C, Hsiung G, Mudge B, Sossi V, Feldman H, Assaly M, Finger E, Pasternack S, Rachisky I, Trost D, Kertesz A, Bernick C, Munic D, Mesulam M, Rogalski E, Lipowski K, Weintraub S, Bonakdarpour B, Kerwin D, Wu C, Johnson N, Sadowsky C, Villena T, Turner R, Johnson K, Reynolds B, Sperling R, Johnson K, Marshall G, Yesavage J, Taylor J, Lane B, Rosen A, Tinklenberg J, Sabbagh M, Belden C, Jacobson S, Sirrel S, Kowall N, Killiany R, Budson A, Norbash A, Johnson P, Obisesan T, Wolday S, Allard J, Lerner A, Ogrocki P, Tatsuoka C, Fatica P, Fletcher E, Maillard P, Olichney J, DeCarli C, Carmichael O, Kittur S, Borrie M, Lee T, Bartha R, Johnson S, Asthana S, Carlsson C, Potkin S, Preda A, Nguyen D, Tariot P, Burke A, Milliken A, Trncic N, Fleisher A, Reeder S, Bates V, Capote H, Rainka M, Scharre D, Kataki M, Kelley B, Zimmerman E, Celmins D, Brown A, Pearlson G, Blank K, Anderson K, Flashman L, Seltzer M, Hynes M, Santulli R, Sink K, Leslie G, Williamson J, Garg P, Watkins F, Ott B, Tremont G, Daiello L, Salloway S, Malloy P, Correia S, Rosen H, Miller B, Perry D, Mintzer J, Spicer K, Bachman D, Finger E, Pasternak S, Rachinsky I, Rogers J, Kertesz A, Drost D, Pomara N, Hernando R, Sarrael A, Schultz S, Smith K, Koleva H, Nam K, Shim H, Relkin N, Chiang G, Lin M, Ravdin L, Smith A, Raj B, Fargher K, Weiner M, Aisen P, Weiner M, Aisen P, Petersen R, Green R, Harvey D, Jack C, Jagust W, Morris J, Saykin A, Shaw L, Toga A, Trojanowki J, Neylan T, Grafman J, Green R, Montine T, Weiner M, Petersen R, Aisen P, Thomas R, Donohue M, Devon G, Sather T, Melissa D, Morrison R, Jiminez G, Neylan T, Jacqueline H, Shannon F, Harvey D, Donohue M, Jack C, Bernstein M, Borowski B, Gunter J, Senjem M, Kejal K, Chad W, Jagust W, Koeppe R, Foster N, Reiman E, Chen K, Landau S, Morris J, Cairns N, Householder E, Shaw L, Trojanowki J, Lee V, Korecka M, Figurski M, Toga A, Karen C, Scott N, Saykin A, Foroud T, Potkin S, Shen L, Faber K, Kim S, Nho K, Weiner M, Karl F, Schneider L, Pawluczyk S, Mauricio B, Brewer J, Vanderswag H, Stern Y, Honig L, Bell K, Fleischman D, Arfanakis K, Shah R, Duara R, Varon D, Greig M, Doraiswamy P, Petrella J, James O, Porsteinsson A, Goldstein B, Martin K, Potkin S, Preda A, Nguyen D, Mintzer J, Massoglia D, Brawman-Mintzer O, Sadowsky C, Martinez W, Villena T, Jagust W, Landau S, Rosen H, Perry D, Turner R, Behan K, Reynolds B, Sperling R, Johnson K, Marshall G, Sabbagh M, Jacobson S, Sirrel S, Obisesan T, Wolday S, Allard J, Johnson S, Fruehling J, Harding S, Peskind E, Petrie E, Li G, Yesavage J, Taylor J, Furst A, Chao S, Relkin N, Chiang G, Ravdin L, Ravdin L. Adding Recognition Discriminability Index to the Delayed Recall Is Useful to Predict Conversion from Mild Cognitive Impairment to Alzheimer's Disease in the Alzheimer's Disease Neuroimaging Initiative. Frontiers In Aging Neuroscience 2017, 9: 46. PMID: 28344552, PMCID: PMC5344912, DOI: 10.3389/fnagi.2017.00046.Peer-Reviewed Original ResearchMild cognitive impairmentDisease Neuroimaging InitiativeAlzheimer's diseaseAlzheimer's Disease Neuroimaging InitiativeCSF biomarkersCognitive impairmentDelayed RecallCSF Aβ1-42 levelsAβ1-42 levelsAmnestic MCI subjectsPredictors of conversionDiagnosis of MCILogistic regression modelingAmyloid biomarkersTest of interactionRecognition discriminability indexRisk factorsAPOE genotypeOdds ratioPredictive valueDiseaseEpisodic memory measuresRAVLT measuresADNI cohortBiomarkersConstruction and Analysis of Weighted Brain Networks from SICE for the Study of Alzheimer's Disease
Munilla J, Ortiz A, Górriz J, Ramírez J, Initiative T, Weiner M, Aisen P, Weiner M, Aisen P, Petersen R, Jack C, Jagust W, Trojanowki J, Toga A, Beckett L, Green R, Saykin A, Morris J, Shaw L, Khachaturian Z, Sorensen G, Carrillo M, Kuller L, Raichle M, Paul S, Davies P, Fillit H, Hefti F, Holtzman D, Mesulam M, Potter W, Snyder P, Schwartz A, Green R, Montine T, Petersen R, Aisen P, Thomas R, Donohue M, Walter S, Gessert D, Sather T, Jiminez G, Balasubramanian A, Mason J, Sim I, Beckett L, Harvey D, Donohue M, Jack C, Bernstein M, Fox N, Thompson P, Schuff N, DeCArli C, Borowski B, Gunter J, Senjem M, Vemuri P, Jones D, Kantarci K, Ward C, Jagust W, Koeppe R, Foster N, Reiman E, Chen K, Mathis C, Landau S, Morris J, Cairns N, Franklin E, Taylor-Reinwald L, Shaw L, Trojanowki J, Lee V, Korecka M, Figurski M, Toga A, Crawford K, Neu S, Saykin A, Foroud T, Potkin S, Shen L, Faber K, Kim S, Nho K, Weiner M, Thal L, Khachaturian Z, Thal L, Buckholtz N, Weiner M, Snyder P, Potter W, Paul S, Albert M, Frank R, Khachaturian Z, Hsiao J, Kaye J, Quinn J, Silbert L, Lind B, Carter R, Dolen S, Schneider L, Pawluczyk S, Becerra M, Teodoro L, Spann B, Brewer J, Vanderswag H, Fleisher A, Heidebrink J, Lord J, Petersen R, Mason S, Albers C, Knopman D, Johnson K, Doody R, Villanueva-Meyer J, Pavlik V, Shibley V, Chowdhury M, Rountree S, Dang M, Stern Y, Honig L, Bell K, Ances B, Morris J, Carroll M, Creech M, Franklin E, Mintun M, Schneider S, Oliver A, Marson D, Geldmacher D, Love M, Griffith R, Clark D, Brockington J, Roberson E, Grossman H, Mitsis E, Shah R, deToledo-Morrell L, Duara R, Greig-Custo M, Barker W, Albert M, Onyike C, D'Agostino D, Kielb S, Sadowski M, Sheikh M, Anaztasia U, Mrunalini G, Doraiswamy P, Petrella J, Borges-Neto S, Wong T, Coleman E, Arnold S, Karlawish J, Wolk D, Clark C, Smith C, Jicha G, Hardy P, Sinha P, Oates E, Conrad G, Lopez O, Oakley M, Simpson D, Porsteinsson A, Goldstein B, Martin K, Makino K, Ismail M, Brand C, Potkin S, Preda A, Nguyen D, Womack K, Mathews D, Quiceno M, Levey A, Lah J, Cellar J, Burns J, Swerdlow R, Brooks W, Apostolova L, Tingus K, Woo E, Silverman D, Lu P, Bartzokis G, Graff-Radford N, Parfitt F, Poki-Walker K, Farlow M, Hake A, Matthews B, Brosch J, Herring S, van Dyck C, Carson R, MacAvoy M, Varma P, Chertkow H, Bergman H, Hosein C, Black S, Stefanovic B, Caldwell C, Hsiung G, Mudge B, Sossi V, Feldman H, Assaly M, Finger E, Pasternack S, Rachisky I, Trost D, Kertesz A, Bernick C, Munic D, Mesulam M, Rogalski E, Lipowski K, Weintraub S, Bonakdarpour B, Kerwin D, Wu C, Johnson N, Sadowsky C, Villena T, Turner R, Johnson K, Reynolds B, Sperling R, Johnson K, Marshall G, Yesavage J, Taylor J, Lane B, Rosen A, Tinklenberg J, Sabbagh M, Belden C, Jacobson S, Sirrel S, Kowall N, Killiany R, Budson A, Norbash A, Johnson P, Obisesan T, Wolday S, Allard J, Lerner A, Ogrocki P, Tatsuoka C, Fatica P, Fletcher E, Maillard P, Olichney J, DeCarli C, Carmichael O, Kittur S, Borrie M, Lee T, Bartha R, Johnson S, Asthana S, Carlsson C, Potkin S, Preda A, Nguyen D, Tariot P, Burke A, Milliken A, Trncic N, Fleisher A, Reeder S, Bates V, Capote H, Rainka M, Scharre D, Kataki M, Kelley B, Zimmerman E, Celmins D, Brown A, Pearlson G, Blank K, Anderson K, Flashman L, Seltzer M, Hynes M, Santulli R, Sink K, Leslie G, Williamson J, Garg P, Watkins F, Ott B, Tremont G, Daiello L, Salloway S, Malloy P, Correia S, Rosen H, Miller B, Perry D, Mintzer J, Spicer K, Bachman D, Finger E, Pasternak S, Rachinsky I, Rogers J, Kertesz A, Drost D, Pomara N, Hernando R, Sarrael A, Schultz S, Smith K, Koleva H, Nam K, Shim H, Relkin N, Chiang G, Lin M, Ravdin L, Smith A, Raj B, Fargher K, Weiner M, Aisen P, Weiner M, Aisen P, Petersen R, Green R, Harvey D, Jack C, Jagust W, Morris J, Saykin A, Shaw L, Toga A, Trojanowki J, Neylan T, Grafman J, Green R, Montine T, Weiner M, Petersen R, Aisen P, Thomas R, Donohue M, Devon G, Sather T, Melissa D, Morrison R, Jiminez G, Neylan T, Jacqueline H, Shannon F, Harvey D, Donohue M, Jack C, Bernstein M, Borowski B, Gunter J, Senjem M, Kejal K, Chad W, Jagust W, Koeppe R, Foster N, Reiman E, Chen K, Landau S, Morris J, Cairns N, Householder E, Shaw L, Trojanowki J, Lee V, Korecka M, Figurski M, Toga A, Karen C, Scott N, Saykin A, Foroud T, Potkin S, Shen L, Faber K, Kim S, Nho K, Weiner M, Karl F, Schneider L, Pawluczyk S, Mauricio B, Brewer J, Vanderswag H, Stern Y, Honig L, Bell K, Fleischman D, Arfanakis K, Shah R, Duara R, Varon D, Greig M, Doraiswamy P, Petrella J, James O, Porsteinsson A, Goldstein B, Martin K, Potkin S, Preda A, Nguyen D, Mintzer J, Massoglia D, Brawman-Mintzer O, Sadowsky C, Martinez W, Villena T, Jagust W, Landau S, Rosen H, Perry D, Turner R, Behan K, Reynolds B, Sperling R, Johnson K, Marshall G, Sabbagh M, Jacobson S, Sirrel S, Obisesan T, Wolday S, Allard J, Johnson S, Fruehling J, Harding S, Peskind E, Petrie E, Li G, Yesavage J, Taylor J, Furst A, Chao S, Relkin N, Chiang G, Ravdin L, Ravdin L. Construction and Analysis of Weighted Brain Networks from SICE for the Study of Alzheimer's Disease. Frontiers In Neuroinformatics 2017, 11: 19. PMID: 28344551, PMCID: PMC5344925, DOI: 10.3389/fninf.2017.00019.Peer-Reviewed Original ResearchPositron emission tomographyAlzheimer's diseaseNumber of subjectsConnectivity patternsCommon neurodegenerative diseaseMore effective treatmentsFunctional connectivity patternsSparse inverse covariance estimatesNeurodegenerative processesEffective treatmentBrain areasControl groupCurrent drugsBrain regionsEmission tomographyDiseaseNeurodegenerative diseasesSmall sample sizeElderly peopleEfficiency of drugsNatural aging processDiscriminant valueBrain networksIllnessBrain
2013
Genome-wide scan of healthy human connectome discovers SPON1 gene variant influencing dementia severity
Jahanshad N, Rajagopalan P, Hua X, Hibar D, Nir T, Toga A, Jack C, Saykin A, Green R, Weiner M, Medland S, Montgomery G, Hansell N, McMahon K, de Zubicaray G, Martin N, Wright M, Thompson P, Weiner M, Aisen P, Weiner M, Aisen P, Petersen R, Jack C, Jagust W, Trojanowski J, Toga A, Beckett L, Green R, Saykin A, Morris J, Liu E, Green R, Montine T, Petersen R, Aisen P, Gamst A, Thomas R, Donohue M, Walter S, Gessert D, Sather T, Beckett L, Harvey D, Gamst A, Donohue M, Kornak J, Jack C, Dale A, Bernstein M, Felmlee J, Fox N, Thompson P, Schuff N, Alexander G, DeCarli C, Jagust W, Bandy D, Koeppe R, Foster N, Reiman E, Chen K, Mathis C, Morris J, Cairns N, Taylor-Reinwald L, Trojanowki J, Shaw L, Lee V, Korecka M, Toga A, Crawford K, Neu S, Saykin A, Foroud T, Potkin S, Shen L, Khachaturian Z, Frank R, Snyder P, Molchan S, Kaye J, Quinn J, Lind B, Dolen S, Schneider L, Pawluczyk S, Spann B, Brewer J, Vanderswag H, Heidebrink J, Lord J, Petersen R, Johnson K, Doody R, Villanueva-Meyer J, Chowdhury M, Stern Y, Honig L, Bell K, Morris J, Ances B, Carroll M, Leon S, Mintun M, Schneider S, Marson D, Griffith R, Clark D, Grossman H, Mitsis E, Romirowsky A, deToledo-Morrell L, Shah R, Duara R, Varon D, Roberts P, Albert M, Onyike C, Kielb S, Rusinek H, de Leon M, Glodzik L, De Santi S, Doraiswamy P, Petrella J, Coleman R, Arnold S, Karlawish J, Wolk D, Smith C, Jicha G, Hardy P, Lopez O, Oakley M, Simpson D, Porsteinsson A, Goldstein B, Martin K, Makino K, Ismail M, Brand C, Mulnard R, Thai G, Mc-Adams-Ortiz C, Womack K, Mathews D, Quiceno M, Diaz-Arrastia R, King R, Weiner M, Martin-Cook K, DeVous M, Levey A, Lah J, Cellar J, Burns J, Anderson H, Swerdlow R, Apostolova L, Lu P, Bartzokis G, Silverman D, Graff-Radford N, Parfitt F, Johnson H, Farlow M, Hake A, Matthews B, Herring S, van Dyck C, Carson R, MacAvoy M, Chertkow H, Bergman H, Hosein C, Black S, Stefanovic B, Caldwell C, Hsiung G, Feldman H, Mudge B, Assaly M, Kertesz A, Rogers J, Trost D, Bernick C, Munic D, Kerwin D, Mesulam M, Lipowski K, Wu C, Johnson N, Sadowsky C, Martinez W, Villena T, Turner R, Johnson K, Reynolds B, Sperling R, Johnson K, Marshall G, Frey M, Yesavage J, Taylor J, Lane B, Rosen A, Tinklenberg J, Sabbagh M, Belden C, Jacobson S, Kowall N, Killiany R, Budson A, Norbash A, Johnson P, Obisesan T, Wolday S, Bwayo S, Lerner A, Hudson L, Ogrocki P, Fletcher E, Carmichael O, Olichney J, DeCarli C, Kittur S, Borrie M, Lee T, Bartha R, Johnson S, Asthana S, Carlsson C, Potkin S, Preda A, Nguyen D, Tariot P, Fleisher A, Reeder S, Bates V, Capote H, Rainka M, Scharre D, Kataki M, Zimmerman E, Celmins D, Brown A, Pearlson G, Blank K, Anderson K, Saykin A, Santulli R, Schwartz E, Sink K, Williamson J, Garg P, Watkins F, Ott B, Querfurth H, Tremont G, Salloway S, Malloy P, Correia S, Rosen H, Miller B, Mintzer J, Longmire C, Spicer K, Finger E, Rachinsky I, Rogers J, Kertesz A, Drost D. Genome-wide scan of healthy human connectome discovers SPON1 gene variant influencing dementia severity. Proceedings Of The National Academy Of Sciences Of The United States Of America 2013, 110: 4768-4773. PMID: 23471985, PMCID: PMC3606977, DOI: 10.1073/pnas.1216206110.Peer-Reviewed Original ResearchMeSH KeywordsAdultAlzheimer DiseaseAutistic DisorderBrainChromosomes, Human, Pair 11Endosomal Sorting Complexes Required for TransportExtracellular Matrix ProteinsFemaleGenetic VariationGenome-Wide Association StudyHumansMagnetic Resonance ImagingMaleNedd4 Ubiquitin Protein LigasesRadiographySeverity of Illness IndexTwins, DizygoticTwins, MonozygoticUbiquitin-Conjugating EnzymesUbiquitin-Protein LigasesConceptsAlzheimer's diseaseBrain connectionsHuman brain wiringDegree of dementiaAssociation of connectivityBrain connectivity patternsConnectivity patternsAberrant connectivityDementia scoreDementia severityElderly populationLower riskPsychiatric disordersHealthy young adult twinsPosthoc analysisBrain wiringBrain diseasesFamily-based studyDiseaseBrain structuresBrain connectivityOlder peopleGene variantsMental retardationYoung adult twins
2012
Response to Letters Regarding Article, “Average Daily Blood Pressure, Not Office Blood Pressure, Is Associated With Progression of Cerebrovascular Disease and Cognitive Decline in Older People”
White W, Campbell P, Wolfson L, Wakefield D, Schmidt J, Hall C, Moscufo N, Guttmann C, Kaplan R, Pearlson G. Response to Letters Regarding Article, “Average Daily Blood Pressure, Not Office Blood Pressure, Is Associated With Progression of Cerebrovascular Disease and Cognitive Decline in Older People”. Circulation 2012, 125: e1018. DOI: 10.1161/circulationaha.112.098509.Peer-Reviewed Original Research
2011
AVERAGE DAILY BLOOD PRESSURE, NOT OFFICE BLOOD PRESSURE, DETERMINES THE PROGRESSION OF CEREBROVASCULAR DISEASE AND FUNCTIONAL DECLINE IN OLDER PERSONS
White W, Wolfson L, Guttman C, Moscufo N, Wakefield D, Kaplan R, Pearlson G. AVERAGE DAILY BLOOD PRESSURE, NOT OFFICE BLOOD PRESSURE, DETERMINES THE PROGRESSION OF CEREBROVASCULAR DISEASE AND FUNCTIONAL DECLINE IN OLDER PERSONS. Journal Of The American College Of Cardiology 2011, 57: e490. DOI: 10.1016/s0735-1097(11)60490-7.Peer-Reviewed Original Research
2010
Aberrant processing of deviant stimuli in schizophrenia revealed by fusion of fMRI and EEG data
Calhoun V, Wu L, Kiehl K, Eichele T, Pearlson G. Aberrant processing of deviant stimuli in schizophrenia revealed by fusion of fMRI and EEG data. Acta Neuropsychiatrica 2010, 22: 127-138. PMID: 21331320, PMCID: PMC3038634, DOI: 10.1111/j.1601-5215.2010.00467.x.Peer-Reviewed Original ResearchFunctional magnetic resonance imagingChronic schizophrenia patientsSchizophrenia patientsJoint independent component analysisHealthy control subjectsFronto-temporal regionsMagnetic resonance imagingLatency abnormalitiesDeviant stimuliControl subjectsHealthy controlsHemodynamic differencesPatientsBipolar disorderAlzheimer's diseaseResonance imagingAuditory oddball stimuliDiseaseSchizophreniaGroup differencesOddball stimuliN2 responseElectrical changesAberrant processingN2 amplitude
2000
Rate of caudate atrophy in presymptomatic and symptomatic stages of Huntington's disease
Aylward E, Codori A, Rosenblatt A, Sherr M, Brandt J, Stine O, Barta P, Pearlson G, Ross C. Rate of caudate atrophy in presymptomatic and symptomatic stages of Huntington's disease. Movement Disorders 2000, 15: 552-560. PMID: 10830423, DOI: 10.1002/1531-8257(200005)15:3<552::aid-mds1020>3.0.co;2-p.Peer-Reviewed Original ResearchConceptsUseful outcome measureCaudate volumeHuntington's diseaseSymptomatic patientsSymptomatic subjectsCaudate atrophyOutcome measuresLongitudinal changesStages of HDMean interscan intervalSerial magnetic resonance imagesHD gene mutationNeurological examSymptomatic groupModerate symptomsMild symptomsSymptomatic stagePresymptomatic carriersTherapeutic studiesTreatment effectivenessPatientsMagnetic resonance imagesDiseaseGene mutationsInterscan interval
1997
Quantitative MRI volume changes in late onset schizophrenia and Alzheimer's disease compared to normal controls
Barta P, Powers R, Aylward E, Chase G, Harris G, Rabins P, Tune L, Pearlson G. Quantitative MRI volume changes in late onset schizophrenia and Alzheimer's disease compared to normal controls. Psychiatry Research 1997, 68: 65-75. PMID: 9104754, DOI: 10.1016/s0925-4927(96)02751-5.Peer-Reviewed Original ResearchConceptsMagnetic resonance imagingOnset schizophreniaAlzheimer's diseaseNormal controlsMRI volume changesLate-onset schizophreniaLateral temporal lobe structuresNon-cognitive symptomsModerate cognitive impairmentTemporal lobe structuresAnterior superior temporal gyrusNormal elderly controlsMedial temporal regionsSuperior temporal gyrusPatient groupSTG volumeAD patientsElderly controlsCognitive impairmentResonance imagingTemporal gyrusTemporal regionsPatientsLobe structuresDisease
1996
Major Depression in Alzheimer's Disease An Interaction Between Gender and Family History
Lyketsos C, Tune L, Pearlson G, Steele C. Major Depression in Alzheimer's Disease An Interaction Between Gender and Family History. Journal Of The Academy Of Consultation-Liaison Psychiatry 1996, 37: 380-384. PMID: 8701017, DOI: 10.1016/s0033-3182(96)71552-9.Peer-Reviewed Original ResearchCT measurement of suprasellar cistern predicts rate of cognitive decline in Alzheimer's disease
Aylward E, Rasmusson D, Brandt J, Raimundo L, Folstein M, Pearlson G. CT measurement of suprasellar cistern predicts rate of cognitive decline in Alzheimer's disease. Journal Of The International Neuropsychological Society 1996, 2: 89-95. PMID: 9375193, DOI: 10.1017/s135561770000093x.Peer-Reviewed Original ResearchConceptsSuprasellar cisternAlzheimer's diseaseAD patientsCT measuresQuantitative computed tomography (CT) measuresMini-Mental State Exam scoreCT measurementsComputed tomography measuresProbable Alzheimer's diseaseState Exam scoreBicaudate ratioBifrontal ratioNeurocognitive declineLateral ventricleThird ventricleCT scanTomography measuresCognitive declineCognitive functionPatientsAdaptive functioningDiseaseScansNeuropsychological measuresCognitive functioningSchizophrenia: A Disease of Heteromodal Association Cortex?
Pearlson G, Petty R, Ross C, Tien A. Schizophrenia: A Disease of Heteromodal Association Cortex? Neuropsychopharmacology 1996, 14: 1-17. PMID: 8719025, DOI: 10.1016/s0893-133x(96)80054-6.Peer-Reviewed Original ResearchConceptsHeteromodal association cortexAssociation cortexLocal gray matter volumeMultiple brain areasGray matter volumeNeuro-imaging studiesNeuropathologic examinationClinical featuresCortical abnormalitiesPrimary involvementBrain areasMatter volumeCortexDiseaseSchizophreniaConsiderable evidenceMagnetic resonanceFindings formNetwork of circuitsLesionsNeocortexAbnormalities
1991
Cortical circumferential profile of SPECT cerebral perfusion in Alzheimer's disease
Harris G, Links J, Pearlson G, Camargo E. Cortical circumferential profile of SPECT cerebral perfusion in Alzheimer's disease. Psychiatry Research 1991, 40: 167-180. PMID: 1780390, DOI: 10.1016/0925-4927(91)90008-e.Peer-Reviewed Original ResearchConceptsCerebral perfusionAlzheimer's diseaseRegional cerebral perfusionElderly control subjectsCerebral cortex functionControl subjectsCortex functionEntire cortexCircumferential profilesNeuroimaging studiesDiseaseIntersubject comparisonsPerfusionCortexDecrease variabilityPatientsIodoamphetamineBrain edgesPhysostigmine in Alzheimer's disease: effects on cognitive functioning, cerebral glucose metabolism analyzed by positron emission tomography and cerebral blood flow analyzed by single photon emission tomography
Tune L, Brandt J, Frost J, Harris G, Mayberg H, Steele C, Burns A, Sapp J, Folstein M, Wagner H, Pearlson G. Physostigmine in Alzheimer's disease: effects on cognitive functioning, cerebral glucose metabolism analyzed by positron emission tomography and cerebral blood flow analyzed by single photon emission tomography. Acta Psychiatrica Scandinavica. Supplementum 1991, 83: 61-65. PMID: 1897377, DOI: 10.1111/j.1600-0447.1991.tb03111.x.Peer-Reviewed Original ResearchMeSH KeywordsAgedAlzheimer DiseaseAmphetaminesBlood GlucoseBrainCerebrovascular CirculationDeoxyglucoseDose-Response Relationship, DrugDrug Administration ScheduleFemaleFluorodeoxyglucose F18HumansMaleMiddle AgedNeuropsychological TestsPhysostigminePilot ProjectsTomography, Emission-ComputedTomography, Emission-Computed, Single-PhotonConceptsCerebral glucose metabolismCerebral blood flowSingle photon emission tomographyPhoton emission tomographyPositron emission tomographyBlood flowEmission tomographyGlucose metabolismAlzheimer's diseaseRegional cerebral glucose metabolismSignificant clinical improvementCognitive functioningClinical improvementMost patientsIntravenous administrationPatientsDiseasePhysostigmineTomographyBrain activityPreliminary findingsMetabolismPronounced improvementPathophysiologyIllnessPET Scans in Schizophrenia: What Have We Learned?
Pearlson G. PET Scans in Schizophrenia: What Have We Learned? Annals Of Clinical Psychiatry 1991, 3: 97-101. DOI: 10.3109/10401239109147976.Peer-Reviewed Original ResearchCentrum semiovale white matter CT changes associated with normal ageing, Alzheimer's disease and late life depression with and without reversible dementia
Pearlson G, Rabins P, Burns A. Centrum semiovale white matter CT changes associated with normal ageing, Alzheimer's disease and late life depression with and without reversible dementia. Psychological Medicine 1991, 21: 321-328. PMID: 1876637, DOI: 10.1017/s0033291700020420.Peer-Reviewed Original ResearchConceptsAlzheimer's diseaseCT attenuation numbersGray matterAttenuation numberCranial CT scanLate-life depressionElderly patientsReversible dementiaPatient groupCT changesLife depressionMajor depressionCentrum semiovaleAttenuation valuesCT scanNormal controlsElderly controlsNeuropsychological evaluationNormal agingDiseasePatientsDepressionCognitive tasksDementiaReliable meansSuprasellar cistern measures as a reflection of dementia in Alzheimer's disease but not Huntington's disease
Aylward E, Karagiozis H, Pearlson G, Folstein M. Suprasellar cistern measures as a reflection of dementia in Alzheimer's disease but not Huntington's disease. Journal Of Psychiatric Research 1991, 25: 31-47. PMID: 1827501, DOI: 10.1016/0022-3956(91)90014-2.Peer-Reviewed Original ResearchConceptsAlzheimer's diseaseSuprasellar cisternDisease patientsAD patientsTemporal lobeCognitive statusHuntington's diseaseRespective age-matched controlsBasal forebrain areasAge-matched controlsHuntington's disease patientsForebrain areasEntorhinal cortexCognitive declinePatientsDiseaseBrain widthLobeHDStatusAtrophyDementiaPerceptual ratingsCortexAssociation between family history of affective disorder and the depressive syndrome of Alzheimer's disease
Pearlson G, Ross C, Lohr W, Rovner B, Chase G, Folstein F. Association between family history of affective disorder and the depressive syndrome of Alzheimer's disease. Alzheimer Disease & Associated Disorders 1991, 5: 47. DOI: 10.1097/00002093-199100510-00009.Peer-Reviewed Original Research
1988
BRAIN IMAGING WITH IODOAMPHETAMINE (IMP) IN PATIENTS WITH HUNTINGTON'S DISEASE (HD)
LaFrance N, Pearlson G, Folstein S, Cole P, Turek J, Kumar A, Bascom M, McDonald A, Folstein M, Wagner H. BRAIN IMAGING WITH IODOAMPHETAMINE (IMP) IN PATIENTS WITH HUNTINGTON'S DISEASE (HD). Clinical Nuclear Medicine 1988, 13: 392. DOI: 10.1097/00003072-198805000-00039.Peer-Reviewed Original ResearchEarly HD patientsMini-Mental StateHD patientsHuntington's diseaseNeurological examinationMini-Mental State scoresDuration of diseaseGenotype-positive individualsEarly Huntington's diseaseMental state scoresForamen of MonroPotential therapeutic interventionsNormal CTFirst manifestationPositive individualsMRI studiesPatientsPreclinical measuresTherapeutic interventionsIodoamphetamineIMP accumulationDiseaseBrain imagingState scoresSignificant decrement