2013
Resting State Electroencephalogram Oscillatory Abnormalities in Schizophrenia and Psychotic Bipolar Patients and Their Relatives from the Bipolar and Schizophrenia Network on Intermediate Phenotypes Study
Narayanan B, O’Neil K, Berwise C, Stevens MC, Calhoun VD, Clementz BA, Tamminga CA, Sweeney JA, Keshavan MS, Pearlson GD. Resting State Electroencephalogram Oscillatory Abnormalities in Schizophrenia and Psychotic Bipolar Patients and Their Relatives from the Bipolar and Schizophrenia Network on Intermediate Phenotypes Study. Biological Psychiatry 2013, 76: 456-465. PMID: 24439302, PMCID: PMC5045030, DOI: 10.1016/j.biopsych.2013.12.008.Peer-Reviewed Original ResearchConceptsFirst-degree relativesSlow beta activityFast alpha activitySZ probandsAlpha activityHealthy control subjectsBeta activityRelative risk estimatesFrontal delta activityEEG spectral activityModerate relative riskPsychotic bipolar patientsLow-frequency activityPsychotic bipolar probandsGroup independent component analysisControl subjectsRelative riskPost-hoc pair-wise comparisonsBipolar patientsGenetic predispositionIntermediate Phenotypes (B-SNIP) studyOscillatory abnormalitiesAnalysis of covarianceUnique endophenotypesBipolar disorder
2012
Hexanucleotide repeat expansions in C9ORF72 in the spectrum of motor neuron diseases
van Rheenen W, van Blitterswijk M, Huisman M, Vlam L, van Doormaal P, Seelen M, Medic J, Dooijes D, de Visser M, van der Kooi A, Raaphorst J, Schelhaas H, van der Pol W, Veldink J, van den Berg L, Weiner M, Aisen P, Petersen R, Clifford R, Jagust W, Trojanowki J, Toga A, Beckett L, Green R, Saykin A, Morris J, Liu E, Montine T, Gamst A, Thomas R, Donohue M, Walter S, Gessert D, Sather T, Beckett L, Harvey D, Gamst A, Donohue M, Kornak J, Dale A, Bernstein M, Felmlee J, Fox N, Thompson P, Schuff N, Alexander G, DeCarli C, Bandy D, Koeppe R, Foster N, Reiman E, Chen K, Mathis C, Cairns N, Taylor-Reinwald L, Shaw L, Lee V, Korecka M, Crawford K, Neu S, Foroud T, Potkin S, Shen L, Kachaturian Z, Frank R, Snyder P, Kaye J, Dolen S, Quinn J, Schneider L, Pawluczyk S, Spann B, Brewer J, Vanderswag H, Heidebrink J, Lord J, Petersen R, Johnson K, S. Doody R, Villanueva-Meyer J, Chowdhury M, Stern Y, Honig L, Bell K, Morris J, Mintun M, Schneider S, Marson D, Griffith R, Clark D, Grossman H, Mitsis E, Romirowsky A, deToledo-Morrell L, Shah R, Duara R, Varon D, Roberts P, Albert M, Onyike C, Kielb S, Rusinek H, de Leon M, Glodzik L, Doraiswamy P, Petrella J, Arnold S, Karlawish J, Wolk D, Smith C, Jicha G, Hardy P, Lopez O, Oakley M, Simpson D, Ismail M, Brand C, Mulnard R, Thai G, Mc-Adams-Ortiz C, Diaz-Arrastia R, Martin-Cook K, DeVous M, Levey A, Lah J, Cellar J, Burns J, Anderson H, Swerdlow R, Bartzokis G, Silverman D, Lu P, Apostolova L, Graff-Radford N, Parfitt F, Johnson H, Farlow M, Herring S, Hake A, van Dyck C, Carson R, MacAvoy M, Chertkow H, Bergman H, Hosein C, Black S, Stefanovic B, Caldwell C, Hsiung G, Feldman H, Assaly M, Kertesz A, Rogers J, Trost D, Bernick C, Munic D, Wu C, Johnson N, Mesulam M, Sadowsky C, Martinez W, Villena T, Turner R, Johnson K, Reynolds B, Sperling R, Frey M, Johnson K, Rosen A, Tinklenberg J, Sabbagh M, Belden C, Jacobson S, Killiany R, Norbash A, Obisesan T, Wolday S, Bwayo S, Lerner A, Hudson L, Ogrocki P, DeCarli C, Fletcher E, Carmichael O, Kittur S, Borrie M, Lee T, Bartha R, Johnson S, Asthana S, Carlsson C, Potkin S, Preda A, Nguyen D, Tariot P, Fleisher A, Reeder S, Bates V, Capote H, Rainka M, Hendin B, Scharre D, Kataki M, Zimmerman E, Celmins D, Brown A, Pearlson G, Blank K, Anderson K, Saykin A, Santulli R, Schwartz E, Williamson J, Sink K, Watkins F, Ott B, Querfurth H, Tremont G, Salloway S, Malloy P, Correia S, Rosen H, Miller B, Mintzer J, Longmire C, Spicer K, Kwon S, Kim J, Cho K, Shin D, Ko Y, Lee S, Cha J, Kim Y, Shin D, Jang H, Choi N, Hong S, Rha J, Hong K, Kim E, Choi J, Sohn S, Shin W, HyukHeo S, Chung K, Park J, Lee J, Park J, Park T, Bae H, Han M, Kwon H, Lee K, Lee T, Jeong D, Lee J, Ashwal S, deVeber G, Ferriero D, Fullerton H, Ichord R, Kirkham F, Lynch J, O'Callaghan F, Pavlakis S, Sebire G, Willan A, Willan A, Sofronas M, Dlamini N, Elbers J, Nowak-Göttl U, Düring C, Krümpel A, Plumb P, Journeycake J, van de Bruinhorst K, Gossett D, Hernandez Chavez M, Monagle P, MacKay M, Barnes C, Furmedge J, Gordon A, Benedict S, Bale J, Nielson D, Abdalla A, Chadehumbe M, Kabbouche M, Karti P, Phillips T, Friedman N, Rizkallah E, Zamel K, Wiznitzer M, Lidsky K, Bernard T, Goldenberg N, Armstrong-Wells J, Booth F, Nash M, Beslow L, Carpenter J, Chang T, Weinstein S, Kan L, Smith R, Maytal J, Sy-Kho R, Yager J, Massicotte P, Ashwal S, McClure C, Bjornson B, Hukin J, Bucevska M, Kent S, Riviello J, Rivkin M, Trenor C, Amlie-Lefond C, Whelan H, Ferriero D, Fullerton H, Fox C, Pavlakis S, Goodman S, Levinson K, Kolk A, Laugesaar R, Talvik T, Imam H, Thomas T, Golomb M, Kirton A, Heyer G, Ganesan V, Saengpattrachai M, Crosswell H, Mancuso A, Tatishvili N, Yeh A, Humpherys P, Abraham L, Alveal L, Ortiz M, Altuna D, Maxit C, Gonzalez V, Alam M, Buckley D, Penney S, Jordan L, Grabowski E, Chan A, Deray M, Khatib Z, Kovacevic G, Kosofsky B, Leifer D, Nass R, Wong V, Catsman C, El-Hakam L, Sebire G, Cholette J, Narang S, Lerner N, Carpenter S, Bischoff K, Frei-Jones M, Masur D, Epstein L, Bagiella E, Hinton V, Gallentine W, Rende E, Provenzale J, Voyvodic J, Song A, Conklin T, O'Hara K, Seinfeld S, Conry J, Glauser T, Ayala J, Facchini R, Sigalova M, Hannigan J, Weiss E, Mancini A, Curran J, Ahlm S, Renaldi J, Umanzour D, Kim A, Hamidullah A, Litherland C, Bonner M, Xu Y, Van de Water V, Grasso S, Kushner D, Culbert J, Bush B, Chandrasekaran S, Davis L, Rogers C, Sabo C, Wang H, Noebels J. Hexanucleotide repeat expansions in C9ORF72 in the spectrum of motor neuron diseases. Neurology 2012, 79: 878-882. PMID: 22843265, DOI: 10.1212/wnl.0b013e3182661d14.Peer-Reviewed Original ResearchMeSH KeywordsAdultAge of OnsetAgedAged, 80 and overAmyotrophic Lateral SclerosisC9orf72 ProteinCohort StudiesConfidence IntervalsDementiaDNADNA Repeat ExpansionFemaleFrontotemporal Lobar DegenerationGenotypeHumansMaleMiddle AgedMotor Neuron DiseaseMuscular Atrophy, SpinalMutationParkinson DiseasePolymerase Chain ReactionProportional Hazards ModelsProteinsSurvivalYoung AdultConceptsProgressive muscular atrophyPrimary lateral sclerosisAmyotrophic lateral sclerosisSporadic amyotrophic lateral sclerosisParkinson's diseaseShorter survivalLateral sclerosisRelatives of patientsFamilial aggregationRepeat expansionHexanucleotide repeat expansionControl subjectsMotor neuronsLarge cohortPatientsMuscular atrophyGenetic testingEarly onsetMajor causeDementiaC9orf72SclerosisFALSEarly ageDutch descent
2010
Aberrant processing of deviant stimuli in schizophrenia revealed by fusion of fMRI and EEG data
Calhoun V, Wu L, Kiehl K, Eichele T, Pearlson G. Aberrant processing of deviant stimuli in schizophrenia revealed by fusion of fMRI and EEG data. Acta Neuropsychiatrica 2010, 22: 127-138. PMID: 21331320, PMCID: PMC3038634, DOI: 10.1111/j.1601-5215.2010.00467.x.Peer-Reviewed Original ResearchFunctional magnetic resonance imagingChronic schizophrenia patientsSchizophrenia patientsJoint independent component analysisHealthy control subjectsFronto-temporal regionsMagnetic resonance imagingLatency abnormalitiesDeviant stimuliControl subjectsHealthy controlsHemodynamic differencesPatientsBipolar disorderAlzheimer's diseaseResonance imagingAuditory oddball stimuliDiseaseSchizophreniaGroup differencesOddball stimuliN2 responseElectrical changesAberrant processingN2 amplitude
2000
White matter hyperintensity volume in late‐onset and early‐onset schizophrenia
Rivkin P, Kraut M, Barta P, Anthony J, Arria A, Pearlson G. White matter hyperintensity volume in late‐onset and early‐onset schizophrenia. International Journal Of Geriatric Psychiatry 2000, 15: 1085-1089. PMID: 11180463, DOI: 10.1002/1099-1166(200012)15:12<1085::aid-gps250>3.0.co;2-x.Peer-Reviewed Original ResearchConceptsWhite matter hyperintensitiesMagnetic resonance imagingWhite matter hyperintensity volumeLate-onset psychosisEarly-onset schizophreniaEarly-onset schizophrenicsNeuro-imaging studiesNeuro-degenerative processesControl subjectsCase ascertainmentOnset psychosisHyperintensity volumeMatter hyperintensitiesOnset schizophreniaWMH volumeAnatomic correlatesResonance imagingStudy designSchizophreniaSignificant differencesWMH measurementsPresent studySchizophrenicsContinuous measureLatent vulnerability
1999
Lack of normal pattern of cerebral asymmetry in familial schizophrenic patients and their relatives — The Maudsley Family Study
Sharma T, Lancaster E, Sigmundsson T, Lewis S, Takei N, Gurling H, Barta P, Pearlson G, Murray R. Lack of normal pattern of cerebral asymmetry in familial schizophrenic patients and their relatives — The Maudsley Family Study. Schizophrenia Research 1999, 40: 111-120. PMID: 10593451, DOI: 10.1016/s0920-9964(99)00143-7.Peer-Reviewed Original ResearchConceptsSchizophrenic patientsOccipitoparietal regionsControl subjectsNormal patternCortical regionsLack of asymmetryFamilial schizophrenic patientsNormal cerebral asymmetryHealthy control subjectsFirst-degree relativesObligate carriersCerebral asymmetryRegional brain volumesUnrelated control subjectsDegree relativesRight sensorimotorNormal brain asymmetryBrain volumeMaudsley Family StudyPatientsOccipital asymmetryUnaffected relativesSchizophreniaBrain asymmetryNormal asymmetry
1998
Brain changes in schizophrenia
Sharma T, Lancaster E, Lee D, Lewis S, Sigmundsson T, Takei N, Gurling H, Barta P, Pearlson G, Murray R. Brain changes in schizophrenia. The British Journal Of Psychiatry 1998, 173: 132-138. PMID: 9850225, DOI: 10.1192/bjp.173.2.132.Peer-Reviewed Original ResearchConceptsLarger lateral ventriclesControl subjectsUnrelated control subjectsLateral ventricleSmaller whole brainLateral ventricular enlargementStructural brain abnormalitiesNormal control subjectsObligate carriersGenetic liabilityVentricular enlargementSample of peopleBrain abnormalitiesBrain changesWhole brainCerebellar volumeBrain structuresMagnetic resonance imagesSchizophreniaVentricleUnaffected siblingsReconstructed magnetic resonance imagesResonance imagesAbnormalitiesVolumetric measurements
1997
Basal ganglia volume in adults with Down syndrome
Aylward E, Li Q, Habbak R, Warren A, Pulsifer M, Barta P, Jerram M, Pearlson G. Basal ganglia volume in adults with Down syndrome. Psychiatry Research 1997, 74: 73-82. PMID: 9204510, DOI: 10.1016/s0925-4927(97)00011-5.Peer-Reviewed Original ResearchConceptsBasal ganglia volumesGanglia volumesDS subjectsBasal gangliaDown syndromeControl subjectsDementia statusNeuropsychological test performanceBrain volumeSmaller total brain volumeVolumes of caudateTotal brain volumeBasal ganglia abnormalitiesOverall brain volumeLarger putamen volumesTotal brainGlobus pallidusPutamen volumeNormal individualsGangliaTest performanceNeuropsychological testsSignificant correlationSyndromeAgeQuantification of Neuroreceptors in the Living Human Brain
Wong *, Pearlson ‡, Tune ‡, Young *, Meltzer *, Dannals *, Ravert *, Reith *, Kuhar †, Gjedde ¶. Quantification of Neuroreceptors in the Living Human Brain. Cerebrovascular And Brain Metabolism Reviews 1997, 17: 331-342. PMID: 9119906, DOI: 10.1097/00004647-199703000-00010.Peer-Reviewed Original ResearchConceptsD2-like dopamine receptorsDrug-naive schizophrenic patientsDopamine receptorsSchizophrenic patientsIllness patientsPatient groupControl subjectsReceptor densityD2 dopamine receptor densityDrug-naive schizophreniaDopamine receptor densityLiving Human BrainBipolar affective illnessD2 dopamine receptorsQuantification of NeuroreceptorsPositron emission tomographyEffect of ageBrain uptakeAffective illnessBipolar illnessNonpsychotic patientsCaudate nucleusNormal controlsNormal volunteersPatients
1996
Striatal dopamine D2 receptor quantification and superior temporal gyrus: Volume determination in 14 chronic schizophrenic subjects
Tune L, Barta P, Wong D, Powers R, Pearlson G, Tien A, Wagner H. Striatal dopamine D2 receptor quantification and superior temporal gyrus: Volume determination in 14 chronic schizophrenic subjects. Psychiatry Research 1996, 67: 155-158. PMID: 8876015, DOI: 10.1016/0925-4927(96)02728-x.Peer-Reviewed Original ResearchConceptsSuperior temporal gyral volumeSuperior temporal gyrusPositron emission tomographyGyral volumeTemporal gyrusNormal groupSchizophrenic groupStriatal D2 receptor densityChronic schizophrenic subjectsRight superior temporal gyrusD2 receptor densityDopamine D2 receptorsStructural neuroimaging techniquesControl subjectsD2 receptorsReceptor densityNormal subjectsPET scansResonance imagingEmission tomographySchizophrenic subjectsBmax valuesNeuroimaging techniquesGyrusReceptor quantification
1994
Mapping of SPECT regional cerebral perfusion abnormalities in obsessive‐compulsive disorder
Harris G, Hoehn‐Saric R, Lewis R, Pearlson G, Streeter C. Mapping of SPECT regional cerebral perfusion abnormalities in obsessive‐compulsive disorder. Human Brain Mapping 1994, 1: 237-248. PMID: 24591194, DOI: 10.1002/hbm.460010403.Peer-Reviewed Original ResearchCerebral perfusion abnormalitiesObsessive-compulsive disorderMagnetic resonance imagingPerfusion abnormalitiesObsessive-compulsive patientsPrior functional neuroimaging studiesSex-matched control subjectsCerebral perfusion differencesRelative cerebral perfusionRight visual association cortexRight frontal cortexVisual association cortexFunctional imaging studiesSingle photon emissionFunctional neuroimaging studiesCerebral valuesCerebral perfusionFrontal perfusionControl subjectsStudies of OCDFrontal cortexCaudate nucleusPerfusion differencesAssociation cortexRegional abnormalities
1993
Dopamine D2 receptor density estimates in schizophrenia: A positron emission tomography study with11C-N-methylspiperone
Tune L, Wong D, Pearlson G, Strauss M, Young T, Shaya E, Dannals R, Wilson A, Ravert H, Sapp J, Cooper T, Chase G, Wagner H. Dopamine D2 receptor density estimates in schizophrenia: A positron emission tomography study with11C-N-methylspiperone. Psychiatry Research 1993, 49: 219-237. PMID: 7909948, DOI: 10.1016/0165-1781(93)90063-m.Peer-Reviewed Original ResearchConceptsPositron emission tomographySchizophrenic patientsBmax valuesEntire groupControl subjectsEmission tomographyDopamine D2 receptor densityNeuroleptic-free patientsDuration of illnessChronic schizophrenic patientsD2 receptor densityClinical characteristicsPatient populationReceptor abnormalitiesCorpus striatumClinical dataReceptor densityPatientsControl groupFunction of ageLate manifestationDifferent radioligandsFour-compartment modelSignificant differencesRadioligand
1992
Putamen volume reduction on magnetic resonance imaging exceeds caudate changes in mild Huntington's disease
Harris G, Pearlson G, Peyser C, Aylward E, Roberts J, Barta P, Chase G, Folstein S. Putamen volume reduction on magnetic resonance imaging exceeds caudate changes in mild Huntington's disease. Annals Of Neurology 1992, 31: 69-75. PMID: 1531910, DOI: 10.1002/ana.410310113.Peer-Reviewed Original ResearchConceptsMild Huntington's diseaseBicaudate ratioCaudate atrophyHuntington's diseaseHD patientsControl subjectsCaudate volumePutamen volumeSex-matched control subjectsNeurological examination scoresPutamen volume reductionsCharacteristic pathological featuresModerate Huntington's diseaseMagnetic resonance imagingCaudate changesNeostriatal atrophyNeuronal lossNeuroradiological studiesComputerized image analysis systemPathological featuresGreater atrophyBrain abnormalitiesCaudate nucleusAtrophyPatients
1991
Cortical circumferential profile of SPECT cerebral perfusion in Alzheimer's disease
Harris G, Links J, Pearlson G, Camargo E. Cortical circumferential profile of SPECT cerebral perfusion in Alzheimer's disease. Psychiatry Research 1991, 40: 167-180. PMID: 1780390, DOI: 10.1016/0925-4927(91)90008-e.Peer-Reviewed Original ResearchConceptsCerebral perfusionAlzheimer's diseaseRegional cerebral perfusionElderly control subjectsCerebral cortex functionControl subjectsCortex functionEntire cortexCircumferential profilesNeuroimaging studiesDiseaseIntersubject comparisonsPerfusionCortexDecrease variabilityPatientsIodoamphetamineBrain edges
1990
Magnetic resonance imaging evidence for a defect of cerebral cortical development in autism
Piven J, Berthier M, Starkstein S, Nehme E, Pearlson G, Folstein S. Magnetic resonance imaging evidence for a defect of cerebral cortical development in autism. American Journal Of Psychiatry 1990, 147: 734-739. PMID: 2343916, DOI: 10.1176/ajp.147.6.734.Peer-Reviewed Original ResearchConceptsControl subjectsMagnetic resonance imaging (MRI) scansCerebral cortical malformationsResonance imaging scansCerebral cortical developmentAutistic subjectsMigration of neuronsMonths of gestationPathogenesis of autismCerebral cortexCortical malformationsImaging scansCortical developmentMacrogyriaPathogenesisMalformationsAbnormalitiesSubjectsScansMagnetic resonancePolymicrogyriaGestationCortexNeuronsMRIConfrontation naming deficit in dementia of depression
Speedie L, Rabins P, Pearlson G, Moberg P. Confrontation naming deficit in dementia of depression. Journal Of Neuropsychiatry 1990, 2: 59-63. PMID: 2136062, DOI: 10.1176/jnp.2.1.59.Peer-Reviewed Original ResearchConceptsDementia of depressionDelayed visual memoryIrreversible dementiaMemory taskVisual memoryFree recallLanguage abilityNondepressed control subjectsDepressed patientsMemoryCognitive impairmentNormal cognitionElderly depressed patientsRecallDepressionTaskDementiaMajor depressionReversible dementiaPatient groupControl subjectsCognitionPatientsDeficitsConfrontation