2023
Identification and validation of urinary CXCL9 as a biomarker for diagnosis of acute interstitial nephritis
Moledina D, Obeid W, Smith R, Rosales I, Sise M, Moeckel G, Kashgarian M, Kuperman M, Campbell K, Lefferts S, Meliambro K, Bitzer M, Perazella M, Luciano R, Pober J, Cantley L, Colvin R, Wilson F, Parikh C. Identification and validation of urinary CXCL9 as a biomarker for diagnosis of acute interstitial nephritis. Journal Of Clinical Investigation 2023, 133: e168950. PMID: 37395276, PMCID: PMC10313360, DOI: 10.1172/jci168950.Peer-Reviewed Original ResearchConceptsUrinary CXCL9External validation cohortValidation cohortControl groupAIN diagnosisDiscovery cohortKidney tissueDiagnostic biomarkersAcute interstitial nephritisCXCL9 mRNA expressionAcute kidney injuryBiopsy-confirmed diagnosisAvailable clinical testsNational InstituteKidney injuryTubulointerstitial nephritisInterstitial nephritisKidney biopsyHistological confirmationHistological diagnosisTreatment optionsLymphocyte chemotaxisCXCL9MRNA expression differencesPatients
2014
Quantification and localization of M2 macrophages in human kidneys with acute tubular injury
Palmer MB, Vichot AA, Cantley LG, Moeckel GW. Quantification and localization of M2 macrophages in human kidneys with acute tubular injury. International Journal Of Nephrology And Renovascular Disease 2014, Volume 7: 415-419. PMID: 25404860, PMCID: PMC4230184, DOI: 10.2147/ijnrd.s66936.Peer-Reviewed Original ResearchAcute tubular injuryMinimal change diseaseM2 macrophagesTubular epithelial cellsTubular injuryMacrophage populationsEpithelial cellsBiopsy-proven diagnosisUltra-structural examinationProximal tubule cellsTubular basement membraneBasement membraneHuman kidney sectionsHuman kidney tissueHLA-DRChange diseaseAbove diagnosisInterstitial macrophagesM1 macrophagesM2 phenotypeInterstitial macrophage populationKidney sectionsKidney tissuePatientsTubule cells