2021
Validation of a Gas Chromatography-Mass Spectrometry Method for the Measurement of the Redox State Metabolic Ratios Lactate/Pyruvate and β-Hydroxybutyrate/Acetoacetate in Biological Samples
Wijngaard R, Perramón M, Parra-Robert M, Hidalgo S, Butrico G, Morales-Ruiz M, Zeng M, Casals E, Jiménez W, Fernández-Varo G, Shulman GI, Cline GW, Casals G. Validation of a Gas Chromatography-Mass Spectrometry Method for the Measurement of the Redox State Metabolic Ratios Lactate/Pyruvate and β-Hydroxybutyrate/Acetoacetate in Biological Samples. International Journal Of Molecular Sciences 2021, 22: 4752. PMID: 33946157, PMCID: PMC8125771, DOI: 10.3390/ijms22094752.Peer-Reviewed Original Research
1997
13C and 31P NMR Studies on the Effects of Increased Plasma Free Fatty Acids on Intramuscular Glucose Metabolism in the Awake Rat*
Jucker B, Rennings A, Cline G, Shulman G. 13C and 31P NMR Studies on the Effects of Increased Plasma Free Fatty Acids on Intramuscular Glucose Metabolism in the Awake Rat*. Journal Of Biological Chemistry 1997, 272: 10464-10473. PMID: 9099689, DOI: 10.1074/jbc.272.16.10464.Peer-Reviewed Original ResearchMeSH KeywordsAlanineAnimalsCarbon IsotopesFatty Acids, NonesterifiedGlucoseGlucose Clamp TechniqueGlucose-6-PhosphateGlycogenGlycolysisHyperinsulinismInfusions, IntravenousInsulinKetonesKineticsLactatesMagnetic Resonance SpectroscopyModels, BiologicalMuscle, SkeletalPhosphorusPyruvatesRatsRats, Sprague-DawleyWakefulnessConceptsPlasma free fatty acids
1995
Triiodothyronine treatment increases substrate cycling between pyruvate carboxylase and malic enzyme in perfused rat liver
Petersen K, Blair J, Shulman G. Triiodothyronine treatment increases substrate cycling between pyruvate carboxylase and malic enzyme in perfused rat liver. Metabolism 1995, 44: 1380-1383. PMID: 7476321, DOI: 10.1016/0026-0495(95)90133-7.Peer-Reviewed Original ResearchConceptsMalic enzymeRelative carbon fluxPyruvate kinaseCarbon fluxesAlanine C2Pyruvate carboxylase fluxSubstrate cyclingKinase activityMalic enzyme activityPyruvate kinase activityPyruvate carboxylaseKinaseEnzymeEnzyme activityCarboxylaseNormal rat liverRat liverNuclear magnetic resonance spectroscopyRelative rolesT3 treatmentOxaloacetateCyclingRecirculating systemPyruvate