2012
The immune reconstitution inflammatory syndrome after antiretroviral therapy initiation in patients with tuberculosis: findings from the SAPiT trial.
Naidoo K, Yende-Zuma N, Padayatchi N, Naidoo K, Jithoo N, Nair G, Bamber S, Gengiah S, El-Sadr WM, Friedland G, Abdool Karim S. The immune reconstitution inflammatory syndrome after antiretroviral therapy initiation in patients with tuberculosis: findings from the SAPiT trial. Annals Of Internal Medicine 2012, 157: 313-24. PMID: 22944873, PMCID: PMC3534856, DOI: 10.7326/0003-4819-157-5-201209040-00004.Peer-Reviewed Original ResearchMeSH KeywordsAdultAIDS-Related Opportunistic InfectionsAnti-Retroviral AgentsAntibiotics, AntitubercularCD4 Lymphocyte CountFemaleHIV InfectionsHumansImmune Reconstitution Inflammatory SyndromeImmunocompromised HostIncidenceKaplan-Meier EstimateMaleProspective StudiesRifampinRisk FactorsSeverity of Illness IndexTuberculosisConceptsImmune reconstitution inflammatory syndromeSequential treatment groupIncidence of IRISReconstitution inflammatory syndromeAntiretroviral therapy initiationART initiationTreatment groupsIRIS incidenceSAPiT trialInflammatory syndromeTherapy initiationTreatment initiationTuberculosis treatmentOpen-label clinical trialCells/LCo-infected patientsEarly ART initiationInitiation of ARTTuberculosis treatment initiationSmear-negative tuberculosisHigher hospitalization ratesWeeks of completionBaseline CD4Antituberculosis treatmentNonambulatory patients
2011
Integration of Antiretroviral Therapy with Tuberculosis Treatment
Abdool Karim S, Naidoo K, Grobler A, Padayatchi N, Baxter C, Gray AL, Gengiah T, Gengiah S, Naidoo A, Jithoo N, Nair G, El-Sadr WM, Friedland G, Abdool Karim Q. Integration of Antiretroviral Therapy with Tuberculosis Treatment. New England Journal Of Medicine 2011, 365: 1492-1501. PMID: 22010915, PMCID: PMC3233684, DOI: 10.1056/nejmoa1014181.Peer-Reviewed Original ResearchConceptsImmune reconstitution inflammatory syndromeT-cell countsEarly ART groupLater-ART groupInitiation of ARTAntiretroviral therapyTuberculosis treatmentIncidence rateCubic millimeterAdverse eventsRisk of IRISHuman immunodeficiency virus (HIV) infectionReconstitution inflammatory syndromeMedian viral loadImmunodeficiency virus infectionAIDS-free survivalRisk of AIDSHigher CD4Median CD4Inflammatory syndromeAmbulatory patientsImmunodeficiency syndromeViral loadContinuation phaseAntiretroviral drugs