2001
Autostimulation of the Epstein-Barr Virus BRLF1 Promoter Is Mediated through Consensus Sp1 and Sp3 Binding Sites
Ragoczy T, Miller G. Autostimulation of the Epstein-Barr Virus BRLF1 Promoter Is Mediated through Consensus Sp1 and Sp3 Binding Sites. Journal Of Virology 2001, 75: 5240-5251. PMID: 11333906, PMCID: PMC114930, DOI: 10.1128/jvi.75.11.5240-5251.2001.Peer-Reviewed Original ResearchMeSH KeywordsB-LymphocytesBase SequenceBinding SitesCell Line, TransformedDNA-Binding ProteinsGene DeletionGene Expression Regulation, ViralHerpesvirus 4, HumanHeterotrimeric GTP-Binding ProteinsHumansImmediate-Early ProteinsMolecular Sequence DataMutagenesis, Site-DirectedPromoter Regions, GeneticProtein BindingReceptors, Cell SurfaceSp1 Transcription FactorSp3 Transcription FactorTrans-ActivatorsTranscription FactorsViral ProteinsVirus ActivationConceptsSp1/Sp3 siteLytic cycleSp3 transcription factorsBinding of Sp1Transcriptional start siteSite-directed mutagenesisGel shift analysisBRLF1 promoterReporter-based assaysEpstein–Barr virus Rta proteinCellular Sp1Own geneConsensus Sp1Transcriptional activationCellular proteinsTranscription factorsStart siteDNA bindingOwn expressionMutagenesis studiesRta proteinSp1Reporter activityTranscription factor Zif268B cellsCD4+ T-Cell Effectors Inhibit Epstein-Barr Virus-Induced B-Cell Proliferation
Nikiforow S, Bottomly K, Miller G. CD4+ T-Cell Effectors Inhibit Epstein-Barr Virus-Induced B-Cell Proliferation. Journal Of Virology 2001, 75: 3740-3752. PMID: 11264363, PMCID: PMC114865, DOI: 10.1128/jvi.75.8.3740-3752.2001.Peer-Reviewed Original ResearchMeSH KeywordsAdultB-LymphocytesCD4-Positive T-LymphocytesCD8-Positive T-LymphocytesCell DivisionCell SizeCells, CulturedEpstein-Barr Virus InfectionsEpstein-Barr Virus Nuclear AntigensFlow CytometryHerpesvirus 4, HumanHumansImmunologic MemoryLymphocyte CountReceptors, IgESerologyTacrolimusT-Lymphocyte SubsetsConceptsEpstein-Barr virusB cell proliferationT cellsB cellsB-cell lymphoproliferative diseaseRemoval of CD4Effector T cellsMemory T cellsT cell effectorsT cell surveillanceCytolytic T cellsEarly proliferative phaseCell linesImmune controlLymphoproliferative diseaseImmunodeficient hostsImmune surveillanceLymphoblastoid cell linesCD4Proliferative phaseImmortalized cell linesCD8CD23VirusInfection
1998
A Functionally Distinct TATA Box Required for Late Progression through the Epstein-Barr Virus Life Cycle
Serio T, Cahill N, Prout M, Miller G. A Functionally Distinct TATA Box Required for Late Progression through the Epstein-Barr Virus Life Cycle. Journal Of Virology 1998, 72: 8338-8343. PMID: 9733880, PMCID: PMC110205, DOI: 10.1128/jvi.72.10.8338-8343.1998.Peer-Reviewed Original ResearchThe Epstein-Barr Virus Rta Protein Activates Lytic Cycle Genes and Can Disrupt Latency in B Lymphocytes
Ragoczy T, Heston L, Miller G. The Epstein-Barr Virus Rta Protein Activates Lytic Cycle Genes and Can Disrupt Latency in B Lymphocytes. Journal Of Virology 1998, 72: 7978-7984. PMID: 9733836, PMCID: PMC110133, DOI: 10.1128/jvi.72.10.7978-7984.1998.Peer-Reviewed Original ResearchMeSH KeywordsBase SequenceB-LymphocytesCell LineChloramphenicol O-AcetyltransferaseDNA PrimersDNA ReplicationDNA-Binding ProteinsGene Expression Regulation, ViralHerpesvirus 4, HumanHumansImmediate-Early ProteinsPromoter Regions, GeneticTrans-ActivatorsTranscription FactorsViral ProteinsVirus LatencyConceptsEpstein-Barr virusLytic cycle genesB lymphocytesEpstein–Barr virus Rta proteinEpithelial cellsLytic cycleDisruption of latencyViral lytic cycleB cell linesEBV entryImmediate early viral genesBZLF1LymphocytesCycle genesExpression of RTARTA functionBRLF1Rta proteinDownstream targetsViral genesViral DNA replicationExpressionCells
1995
Transmissible Retrovirus in Epstein-Burr Virus-Producer B95-8 Cells
Sun R, Grogan E, Shedd D, Bykovsky A, Kushnaryov V, Grossberg S, Miller G. Transmissible Retrovirus in Epstein-Burr Virus-Producer B95-8 Cells. Virology 1995, 209: 374-383. PMID: 7778272, DOI: 10.1006/viro.1995.1269.Peer-Reviewed Original ResearchMeSH KeywordsAmino Acid SequenceAnimalsB-LymphocytesBase SequenceBetaretrovirusCallithrixCell LineCloning, MolecularDNA PrimersDNA, ComplementaryGene LibraryGene Products, gagGenes, gagHerpesvirus 4, HumanHumansMicroscopy, ElectronMolecular Sequence DataPolymerase Chain ReactionRepetitive Sequences, Nucleic AcidSaimiriT-LymphocytesVirus ReplicationConceptsEpstein-Barr virusB95-8 cellsAbsence of EBVCell linesB95-8 isolateB95-8 strainMarmoset cell linesHuman lymphoid cell linesT cell linesLymphoid cell linesType D retrovirusHuman BLymphocyte immortalizationInfectious virusViral replicationHuman isolatesGag regionBiologic propertiesTransmissible retrovirusUltrastructural appearanceD retrovirusesAmino acid changesVirusSMRVGag sequences
1985
An identification of a transforming region of Epstein-Barr viral DNA cannot be confirmed
Miller G, Sugden B. An identification of a transforming region of Epstein-Barr viral DNA cannot be confirmed. Virology 1985, 143: 478-484. PMID: 2998023, DOI: 10.1016/0042-6822(85)90387-3.Peer-Reviewed Original Research
1984
Regions of the EBV genome involved in latency and lymphocyte immortalization.
Miller G. Regions of the EBV genome involved in latency and lymphocyte immortalization. Medical Virology 1984, 30: 107-28. PMID: 6087408.Peer-Reviewed Original ResearchAnimalsAntigens, ViralB-LymphocytesCell NucleusCell Transformation, ViralChildChild, PreschoolChromosome DeletionDNA, ViralEpstein-Barr Virus Nuclear AntigensFemaleGenes, ViralHerpesvirus 4, HumanHumansLymphomaMaleRepetitive Sequences, Nucleic AcidRNA, ViralTranscription, GeneticTumor Virus InfectionsVirionVirus Replication
1981
Copy number and location of Epstein-Barr viral genomes in neonatal human lymphocytes transformed after separation by size and treatment with mitogens
Anvret M, Miller G. Copy number and location of Epstein-Barr viral genomes in neonatal human lymphocytes transformed after separation by size and treatment with mitogens. Virology 1981, 111: 47-55. PMID: 6263010, DOI: 10.1016/0042-6822(81)90652-8.Peer-Reviewed Original ResearchConceptsNeonatal human lymphocytesEBV DNACell linesStaphylococcus aureusEpstein-Barr viral genomeHuman lymphocytesEBV DNA copiesEpstein-Barr virusPurified B lymphocytesFresh umbilical cordsB95-8 strainFicoll-Hypaque gradientDifferent cell linesEB virusMedian numberUmbilical cordB lymphocytesViral infectionViral genomeLymphocytesLipopolysaccharideSmall cell fractionPhysiologic stateTime of exposureCell fractionEpstein-Barr Viral DNA: Infectivity for Human Placental Cells
Miller G, Grogan E, Heston L, Robinson J, Smith D. Epstein-Barr Viral DNA: Infectivity for Human Placental Cells. Science 1981, 212: 452-455. PMID: 6259735, DOI: 10.1126/science.6259735.Peer-Reviewed Original Research
1980
Diffuse Polyclonal B-Cell Lymphoma during Primary Infection with Epstein–Barr Virus
Robinson J, Brown N, Andiman W, Halliday K, Francke U, Robert M, Andersson-Anvret M, Horstmann D, Miller G. Diffuse Polyclonal B-Cell Lymphoma during Primary Infection with Epstein–Barr Virus. New England Journal Of Medicine 1980, 302: 1293-1297. PMID: 6245364, DOI: 10.1056/nejm198006053022306.Peer-Reviewed Original Research