2001
PREVALENCE OF ANTIBODIES TO HUMAN HERPESVIRUS 8 (HHV-8) IN SAUDI ARABIAN PATIENTS WITH AND WITHOUT RENAL FAILURE1234
Almuneef M, Nimjee S, Khoshnood K, Miller G, Rigsby M. PREVALENCE OF ANTIBODIES TO HUMAN HERPESVIRUS 8 (HHV-8) IN SAUDI ARABIAN PATIENTS WITH AND WITHOUT RENAL FAILURE1234. Transplantation 2001, 71: 1120-1124. PMID: 11374413, DOI: 10.1097/00007890-200104270-00019.Peer-Reviewed Original ResearchConceptsEnd-stage renal diseasePosttransplantation Kaposi's sarcomaPrevalence of antibodiesKaposi's sarcomaHuman herpesvirus 8HHV-8Renal diseaseHerpesvirus 8High incidenceHHV-8-seropositive individualsSmall viral capsid antigenHHV-8 infectionRenal transplant recipientsViral capsid antigenComparison groupArea of residenceSeronegative subjectsESRD patientsSeropositive subjectsTransplant recipientsCapsid antigenSerologic evidenceSeropositive individualsCommon cancerPatients
1999
Cellular Tropism and Viral Interleukin-6 Expression Distinguish Human Herpesvirus 8 Involvement in Kaposi’s Sarcoma, Primary Effusion Lymphoma, and Multicentric Castleman’s Disease
Staskus K, Sun R, Miller G, Racz P, Jaslowski A, Metroka C, Brett-Smith H, Haase A. Cellular Tropism and Viral Interleukin-6 Expression Distinguish Human Herpesvirus 8 Involvement in Kaposi’s Sarcoma, Primary Effusion Lymphoma, and Multicentric Castleman’s Disease. Journal Of Virology 1999, 73: 4181-4187. PMID: 10196314, PMCID: PMC104197, DOI: 10.1128/jvi.73.5.4181-4187.1999.Peer-Reviewed Original ResearchMeSH KeywordsCastleman DiseaseGene ExpressionHerpesvirus 8, HumanHumansInterleukin-6LymphomaSarcoma, KaposiTranscription, GeneticConceptsViral gene expressionMulticentric Castleman's diseasePrimary effusion lymphomaLevel of expressionCell typesGene expressionViral genesKaposi's sarcomaInfected cell typesLytic cycle viral gene expressionHeterogeneous cell typesCastleman's diseaseInterleukin-6Lytic cycle genesEffusion lymphomaHuman immunodeficiency virus-positive individualsPathogenesis of PELPredominant infected cell typeHuman herpesvirus 8 infectionViral homologueVirus-positive individualsVIL-6B cell growthAltered expressionGenesKinetics of Kaposi’s Sarcoma-Associated Herpesvirus Gene Expression
Sun R, Lin S, Staskus K, Gradoville L, Grogan E, Haase A, Miller G. Kinetics of Kaposi’s Sarcoma-Associated Herpesvirus Gene Expression. Journal Of Virology 1999, 73: 2232-2242. PMID: 9971806, PMCID: PMC104468, DOI: 10.1128/jvi.73.3.2232-2242.1999.Peer-Reviewed Original ResearchConceptsHerpesvirus gene expressionKaposi's sarcoma-associated herpesvirusSarcoma-associated herpesvirusGene expressionLytic cycleEarly genesVIL-6Cell linesKSHV DNA replicationG protein-coupled receptorsProtein-coupled receptorsSingle-cell assaysPrimary effusion lymphoma cell linesImmediate early genesPAN RNADNA replicationEpstein-Barr virus BZLF1Nuclear RNALate genesBovine herpesvirus 4KS biopsiesPEL cell linesVBcl-2Positional homologueKinetic classes
1998
A viral gene that activates lytic cycle expression of Kaposi’s sarcoma-associated herpesvirus
Sun R, Lin S, Gradoville L, Yuan Y, Zhu F, Miller G. A viral gene that activates lytic cycle expression of Kaposi’s sarcoma-associated herpesvirus. Proceedings Of The National Academy Of Sciences Of The United States Of America 1998, 95: 10866-10871. PMID: 9724796, PMCID: PMC27987, DOI: 10.1073/pnas.95.18.10866.Peer-Reviewed Original ResearchMeSH KeywordsAmino Acid SequenceBase SequenceCloning, MolecularDNA PrimersDNA, ComplementaryGene Expression Regulation, NeoplasticGenes, ViralHerpesvirus 4, HumanHerpesvirus 8, HumanHumansMolecular Sequence DataSarcoma, KaposiSequence Homology, Amino AcidTranscription, GeneticTumor Cells, CulturedVirus ActivationConceptsEpstein-Barr virusKaposi's sarcoma-associated herpesvirusSarcoma-associated herpesvirusSmall viral capsid antigenPathogenesis of KSHVLytic cycle gene expressionViral capsid antigenLatent viral genomeCapsid antigenLytic cycle genesInterleukin-6Immediate early genesViral cytokineEarly lytic genesLytic genesHerpesvirusVirusViral genesViral genomeExpressionGene expressionCytokinesPathogenesisCycle genesGenesHigh Prevalence of Antibodies to Human Herpesvirus 8 in Relatives of Patients with Classic Kaposi's Sarcoma from Sardinia
Angeloni A, Heston L, Uccini S, Sirianni M, Cottoni F, Masala M, Cerimele D, Lin S, Sun R, Rigsby M, Faggioni A, Miller G. High Prevalence of Antibodies to Human Herpesvirus 8 in Relatives of Patients with Classic Kaposi's Sarcoma from Sardinia. The Journal Of Infectious Diseases 1998, 177: 1715-1718. PMID: 9607855, DOI: 10.1086/517429.Peer-Reviewed Original ResearchConceptsSmall viral capsid antigenPrevalence of antibodiesClassic Kaposi's sarcomaHigh incidence areaKaposi's sarcomaActive HHV-8 infectionHuman herpesvirus type 8HHV-8 infectionViral capsid antigenRelatives of patientsHuman herpesvirus 8Familial risk factorsCapsid antigenRisk factorsHigh prevalenceKS patientsHerpesvirus 8SarcomaIncidence areaPopulation agesPatientsVertical transmissionPrevalenceAntibodiesType 8SEROLOGIC ASSOCIATION OF HUMAN HERPESVIRUS EIGHT WITH POSTTRANSPLANT KAPOSI'S SARCOMA IN SAUDI ARABIA1
Wajeh Q, Othman A, Khalid A, Lin3 4, Ren S, Lee H, Ross5 6, Rigsby7 8, Miller3 5. SEROLOGIC ASSOCIATION OF HUMAN HERPESVIRUS EIGHT WITH POSTTRANSPLANT KAPOSI'S SARCOMA IN SAUDI ARABIA1. Transplantation 1998, 65: 583-585. PMID: 9500639, DOI: 10.1097/00007890-199802270-00024.Peer-Reviewed Original ResearchConceptsPosttransplant Kaposi's sarcomaRenal transplant patientsKaposi's sarcomaTransplant patientsSmall viral capsid antigenRenal transplant recipientsTertiary care hospitalViral capsid antigenCross-sectional studyHHV8 antigensSerologic associationsTransplant recipientsRenal failureCare hospitalCapsid antigenCommon cancerControl subjectsSaudi ArabiaSeroreactivity ratesKS patientsSerologic resultsControl groupControl individualsPatientsSarcoma
1996
Antibodies to Butyrate-Inducible Antigens of Kaposi's Sarcoma–Associated Herpesvirus in Patients with HIV-1 Infection
Miller G, Rigsby M, Heston L, Grogan E, Sun R, Metroka C, Levy J, Gao S, Chang Y, Moore P. Antibodies to Butyrate-Inducible Antigens of Kaposi's Sarcoma–Associated Herpesvirus in Patients with HIV-1 Infection. New England Journal Of Medicine 1996, 334: 1292-1297. PMID: 8609946, DOI: 10.1056/nejm199605163342003.Peer-Reviewed Original ResearchConceptsHIV-1-infected patientsEpstein-Barr virusKaposi's sarcomaBC-1 cellsHuman immunodeficiency virus type 1 (HIV-1) infectionVirus type 1 infectionPositive serologic responseHIV-1 infectionType 1 infectionHigh-risk populationAntigen-positive cellsPresence of antibodiesPositive predictive valueEBV antigensKSHV antigensP40 antigenSerologic markersSerologic responseKaposi's Sarcoma-Associated HerpesvirusEtiologic roleSerologic testsPatientsSarcomaPredictive valueKSHV infection