Degradable bioadhesive nanoparticles for prolonged intravaginal delivery and retention of elvitegravir
Mohideen M, Quijano E, Song E, Deng Y, Panse G, Zhang W, Clark MR, Saltzman WM. Degradable bioadhesive nanoparticles for prolonged intravaginal delivery and retention of elvitegravir. Biomaterials 2017, 144: 144-154. PMID: 28829952, PMCID: PMC5581224, DOI: 10.1016/j.biomaterials.2017.08.029.Peer-Reviewed Original ResearchConceptsPolymer carrierPolymeric nanoparticlesIntravaginal deliveryBioadhesive nanoparticlesNanoparticlesHuman immunodeficiency virusPromising strategyProtective mucus layerReproductive tractFormulation 1Residence timePolyEpithelial cell populationsSite of actionImmunodeficiency virusRetentionIntravaginal administrationVaginal lumenMucosal surfacesSustained protectionTopical applicationSTD epidemicsElvitegravirHormone cyclesMucus layer