1993
Binding of the cocaine analog 2 beta-carbomethoxy-3 beta-(4-[125I]iodophenyl)tropane to serotonin and dopamine transporters: different ionic requirements for substrate and 2 beta-carbomethoxy-3 beta-(4-[125I]iodophenyl)tropane binding.
Wall S, Innis R, Rudnick G. Binding of the cocaine analog 2 beta-carbomethoxy-3 beta-(4-[125I]iodophenyl)tropane to serotonin and dopamine transporters: different ionic requirements for substrate and 2 beta-carbomethoxy-3 beta-(4-[125I]iodophenyl)tropane binding. Molecular Pharmacology 1993, 43: 264-70. PMID: 8429827.Peer-Reviewed Original ResearchMeSH KeywordsAnimalsBinding, CompetitiveBlood PlateletsCarrier ProteinsCocaineCorpus StriatumDopamineDopamine Plasma Membrane Transport ProteinsHydrogen-Ion ConcentrationIn Vitro TechniquesIonsMembrane GlycoproteinsMembrane Transport ProteinsNerve Tissue ProteinsOsmolar ConcentrationProtein BindingRadioligand AssayRatsSerotoninSerotonin Plasma Membrane Transport Proteins
1992
p-Chloroamphetamine induces serotonin release through serotonin transporters.
Rudnick G, Wall S. p-Chloroamphetamine induces serotonin release through serotonin transporters. Biochemistry 1992, 31: 6710-8. PMID: 1322169, DOI: 10.1021/bi00144a010.Peer-Reviewed Original ResearchMeSH KeywordsBinding, CompetitiveBiological TransportBlood PlateletsCarrier ProteinsCell MembraneChloridesHumansHydrogen-Ion ConcentrationImipramineKineticsLithiumLithium ChlorideMembrane GlycoproteinsMembrane Transport ProteinsNerve Tissue ProteinsP-ChloroamphetamineRadioisotope Dilution TechniqueSerotoninSerotonin Plasma Membrane Transport ProteinsTritiumConceptsPlasma membrane vesiclesMembrane vesiclesChromaffin granule membrane vesiclesVesicular amine transporterATP hydrolysisBovine adrenal chromaffin granulesSerotonin transporterAdrenal chromaffin granulesPrevents accumulationAmine transportersPresence of Mg2TransportersVesiclesChromaffin granulesModel systemDelta pHHuman plateletsATPEffluxManner characteristicAccumulationTransmembraneNaCl gradientPCA's abilityP-chloroamphetamine
1989
2-Iodoimipramine, a novel ligand for the serotonin transporter.
Humphreys C, Cassel D, Rudnick G. 2-Iodoimipramine, a novel ligand for the serotonin transporter. Molecular Pharmacology 1989, 36: 620-6. PMID: 2811859.Peer-Reviewed Original ResearchZwitterionic and Anionic Forms of a Serotonin Analog as Transport Substrates
Rudnick G, Kirk K, Fishkes H, Schuldiner S. Zwitterionic and Anionic Forms of a Serotonin Analog as Transport Substrates. Journal Of Biological Chemistry 1989, 264: 14865-14868. PMID: 2549040, DOI: 10.1016/s0021-9258(18)63781-0.Peer-Reviewed Original ResearchConceptsBiogenic amine transportersAmine transportersPlasma membrane serotonin transporterSubstrate translocationBovine chromaffin granulesTransport substratesHuman blood plateletsSerotonin transportChromaffin granulesTransportersBlood plateletsSerotonin transporterKmIdentical ratesTranslocationSubstrateTransport
1983
The serotonin transporter-imipramine "receptor".
Talvenheimo J, Fishkes H, Nelson P, Rudnick G. The serotonin transporter-imipramine "receptor". Journal Of Biological Chemistry 1983, 258: 6115-6119. PMID: 6853478, DOI: 10.1016/s0021-9258(18)32380-9.Peer-Reviewed Original ResearchMeSH KeywordsAnimalsBinding, CompetitiveBiological TransportBlood PlateletsCarrier ProteinsCell MembraneImipramineSerotoninSodiumSwine
1980
Solubilization of the platelet plasma membrane serotonin transporter in an active form.
Talvenheimo J, Rudnick G. Solubilization of the platelet plasma membrane serotonin transporter in an active form. Journal Of Biological Chemistry 1980, 255: 8606-8611. PMID: 7410380, DOI: 10.1016/s0021-9258(18)43541-7.Peer-Reviewed Original Research
1979
Mechanism of imipramine inhibition of platelet 5-hydroxytryptamine transport.
Talvenheimo J, Nelson P, Rudnick G. Mechanism of imipramine inhibition of platelet 5-hydroxytryptamine transport. Journal Of Biological Chemistry 1979, 254: 4631-4635. PMID: 438209, DOI: 10.1016/s0021-9258(17)30057-1.Peer-Reviewed Original ResearchMeSH KeywordsAnimalsBinding, CompetitiveBiological TransportBlood PlateletsImipramineKineticsReceptors, DrugSerotoninSodiumSwine
1975
Photoinactivation of the beta-galactoside transport system in Escherichia coli membrane vesicles with an impermeant azidophenylgalactoside.
Rudnick G, Kaback H. Photoinactivation of the beta-galactoside transport system in Escherichia coli membrane vesicles with an impermeant azidophenylgalactoside. Journal Of Biological Chemistry 1975, 250: 6847-6851. PMID: 1099095, DOI: 10.1016/s0021-9258(19)41009-0.Peer-Reviewed Original ResearchPhotoinactivation of the beta-galactoside transport system in Escherichia coli membrane vesicles with 2-nitro-4-azidophenyl-1-thio-beta-D-galactopyranoside.
Rudnick G, Kaback H, Weil R. Photoinactivation of the beta-galactoside transport system in Escherichia coli membrane vesicles with 2-nitro-4-azidophenyl-1-thio-beta-D-galactopyranoside. Journal Of Biological Chemistry 1975, 250: 1371-1375. PMID: 1089657, DOI: 10.1016/s0021-9258(19)41823-1.Peer-Reviewed Original ResearchConceptsMembrane vesiclesBeta-galactoside transport systemEscherichia coli membrane vesiclesEscherichia coli ML 308Lac carrier proteinD-lactateAmino acid transportTransport systemSteady-state levelsML 308Lactose transportAcid transportCarrier proteinVesiclesD-galactopyranosideApparent KmCompetitive inhibitor