1993
From synapse to vesicle: The reuptake and storage of biogenic amine neurotransmitters
Rudnick G, Clark J. From synapse to vesicle: The reuptake and storage of biogenic amine neurotransmitters. Biochimica Et Biophysica Acta 1993, 1144: 249-263. PMID: 8104483, DOI: 10.1016/0005-2728(93)90109-s.Peer-Reviewed Reviews, Practice Guidelines, Standards, and Consensus StatementsConceptsPresynaptic plasma membraneBiogenic amine neurotransmittersEndogenous regulatory mechanismsSynaptic transmitter levelsPlasma membraneIndividual proteinsRegulatory mechanismsTransport systemMolecular levelSynaptic vesiclesAmine neurotransmittersIon gradientsTransportersVesiclesCDNARapid progressProteinNeurotransmittersRegulationMechanismMembraneSynapseTransmitter levels
1992
The molecular mechanism of "ecstasy" [3,4-methylenedioxy-methamphetamine (MDMA)]: serotonin transporters are targets for MDMA-induced serotonin release.
Rudnick G, Wall S. The molecular mechanism of "ecstasy" [3,4-methylenedioxy-methamphetamine (MDMA)]: serotonin transporters are targets for MDMA-induced serotonin release. Proceedings Of The National Academy Of Sciences Of The United States Of America 1992, 89: 1817-1821. PMID: 1347426, PMCID: PMC48544, DOI: 10.1073/pnas.89.5.1817.Peer-Reviewed Original ResearchConceptsPlasma membrane vesiclesMembrane vesiclesAmine transportersVesicular amine transporterBiogenic amine transportersSecretory vesiclesPlasma membraneATP hydrolysisMolecular mechanismsBovine adrenal chromaffin granulesSerotonin transporterAdrenal chromaffin granulesTransportersDirect interactionVesiclesChromaffin granulesHuman plateletsManner characteristicEffluxTransmembraneATPMDMA actionMechanismBindingMembrane
1978
Platelet 5-hydroxytryptamine transport, an electroneutral mechanism coupled to potassium.
Rudnick G, Nelson P. Platelet 5-hydroxytryptamine transport, an electroneutral mechanism coupled to potassium. Biochemistry 1978, 17: 4739-42. PMID: 728383, DOI: 10.1021/bi00615a021.Peer-Reviewed Original ResearchConceptsPlasma membrane vesiclesLipophilic cation triphenylmethylphosphoniumMembrane potentialMembrane vesiclesElectroneutral mechanismVesicle membraneIon effluxPorcine blood plateletsAbsence of valinomycinAddition of valinomycinPotassium gradientBlood plateletsValinomycinElectrogenic mechanismMembraneNet influxMechanismDinitrophenolVesiclesTransportLittle effectInfluxTriphenylmethylphosphoniumAbsenceEfflux