2009
Detection of coronary artery disease with perfusion stress echocardiography using a novel ultrasound imaging agent: two Phase 3 international trials in comparison with radionuclide perfusion imaging
Senior R, Monaghan M, Main M, Zamorano J, Tiemann K, Agati L, Weissman N, Klein A, Marwick T, Ahmad M, DeMaria A, Zabalgoitia M, Becher H, Kaul S, Udelson J, Wackers F, Walovitch R, Picard M. Detection of coronary artery disease with perfusion stress echocardiography using a novel ultrasound imaging agent: two Phase 3 international trials in comparison with radionuclide perfusion imaging. European Heart Journal - Cardiovascular Imaging 2009, 10: 26-35. PMID: 19131498, DOI: 10.1093/ejechocard/jen321.Peer-Reviewed Original ResearchMeSH KeywordsAdolescentAdultAgedAged, 80 and overArea Under CurveContrast MediaCoronary Artery DiseaseDipyridamoleEchocardiography, StressFemaleFluorocarbonsGated Blood-Pool ImagingHumansImage EnhancementImage Interpretation, Computer-AssistedInternational CooperationMaleMiddle AgedObserver VariationROC CurveSensitivity and SpecificityStatistics, NonparametricTomography, Emission-Computed, Single-PhotonYoung AdultConceptsChest pain patientsPain patientsStress echocardiographyPerfusion imagingNon-inferior sensitivityPhase 3 trialCoronary artery diseaseCoronary artery disease detectionQuantitative coronary angiographyNon-inferiority analysisRadionuclide perfusion imagingSingle photon emissionAdverse eventsArtery diseaseCoronary angiographyBlinded cardiologistsClinical reviewDipyridamole stressMyocardial perfusionSPECT perfusionInternational trialRAMP 1Diagnostic performanceSPECTCharacteristic curve
2003
Comparison of 16-frame and 8-frame gated SPET imaging for determination of left ventricular volumes and ejection fraction
Navare SM, Wackers FJ, Liu YH. Comparison of 16-frame and 8-frame gated SPET imaging for determination of left ventricular volumes and ejection fraction. European Journal Of Nuclear Medicine And Molecular Imaging 2003, 30: 1330-1337. PMID: 12838373, DOI: 10.1007/s00259-003-1231-0.Peer-Reviewed Original ResearchConceptsSingle photon emission tomographyEnd-diastolic volumeEnd-systolic volumePerfusion defectsEjection fractionMyocardial perfusionSPET imagesLV volumesLeft ventricular end-diastolic volumeVentricular end-diastolic volumeSmaller end-systolic volumeLarger end-diastolic volumeSignificant perfusion defectsMyocardial perfusion defectsRadiotracer doseHigher LVEFVentricular functionLow doseVentricular volumeEmission tomographyLV parametersDoseLVEFECG gatingPatientsPrognostic significance of ischemic electrocardiographic changes during adenosine infusion in patients with normal myocardial perfusion imaging
Abbott B, Afshar M, Berger A, Wackers F. Prognostic significance of ischemic electrocardiographic changes during adenosine infusion in patients with normal myocardial perfusion imaging. Journal Of Nuclear Cardiology 2003, 10: 9-16. PMID: 12569326, DOI: 10.1067/mnc.2002.127625.Peer-Reviewed Original ResearchConceptsNormal myocardial perfusion imagingAdenosine myocardial perfusion imagingST-segment depressionMyocardial perfusion imagingIschemic ECG changesCardiac eventsECG changesAdenosine infusionCardiac deathPrognostic significanceECG groupNormal myocardial perfusion imagesBaseline electrocardiographic abnormalitiesAdverse cardiac eventsIschemic electrocardiographic changesNonfatal myocardial infarctionSubsequent cardiac eventsFuture cardiac eventsNormal myocardial perfusionSex-matched groupPerfusion imagesECG evidenceElectrocardiographic abnormalitiesIndependent predictorsElectrocardiographic changes
2000
Effect of left ventricular volume on results of coronary artery bypass grafting
Kim R, Ugurlu B, Tereb D, Wackers F, Tellides G, Elefteriades J. Effect of left ventricular volume on results of coronary artery bypass grafting. The American Journal Of Cardiology 2000, 86: 1261-1264. PMID: 11090805, DOI: 10.1016/s0002-9149(00)01216-9.Peer-Reviewed Original ResearchConceptsCoronary artery bypassArtery bypassSignificant left ventricular dilationLeft ventricular dilationLV chamber sizeLV ejection fractionMedium-term survivalSurgical revascularizationAngina symptomsEjection fractionIschemic cardiomyopathyLV dilationVentricular dilationVentricular sizeVentricular volumePatientsSignificant reductionBypassChamber sizeDilationRevascularizationCardiomyopathySymptomsAssessment of left ventricular ejection fraction with quantitative gated SPECT: Accuracy and correlation with first-pass radionuclide angiography
Vallejo E, Dione D, Sinusas A, Wackers F. Assessment of left ventricular ejection fraction with quantitative gated SPECT: Accuracy and correlation with first-pass radionuclide angiography. Journal Of Nuclear Cardiology 2000, 7: 461-470. PMID: 11083195, DOI: 10.1067/mnc.2000.107820.Peer-Reviewed Original ResearchConceptsVentricular ejection fractionEjection fractionPatient studiesLeft ventricular ejection fractionExtracardiac activityFirst-pass radionuclide angiographyLarger end-diastolic volumeStress-induced ischemiaEnd-diastolic volumeQuantitative gated SPECTSingle photon emissionAbnormal LVEFNormal LVEFRadionuclide angiographyDiastolic volumeLVEFPerfusion defectsLVEF valuesSame patientHeart sizeLeft ventricleGated SPECTSPECT studiesQGSMean rest
1999
Failure to Improve Left Ventricular Function After Coronary Revascularization for Ischemic Cardiomyopathy Is Not Associated With Worse Outcome
Samady H, Elefteriades J, Abbott B, Mattera J, McPherson C, Wackers F. Failure to Improve Left Ventricular Function After Coronary Revascularization for Ischemic Cardiomyopathy Is Not Associated With Worse Outcome. Circulation 1999, 100: 1298-1304. PMID: 10491374, DOI: 10.1161/01.cir.100.12.1298.Peer-Reviewed Original ResearchConceptsVentricular functionIschemic cardiomyopathyGroup AHeart failure scoreLeft ventricular functionIschemic LV dysfunctionPoor patient outcomesB. Group ALack of improvementBaseline LVEFEffective revascularizationImproved LVEFCoronary revascularizationLV dysfunctionConsecutive patientsIntraoperative variablesPostoperative improvementCardiac deathLV functionPoor outcomeViable myocardiumLVEF assessmentIschemic myocardiumPatient outcomesWorse outcomes
1997
Improved diagnostic accuracy of planar imaging with technetium 99m-labeled tetrofosmin compared with thallium-201 for the detection of coronary artery disease
Khattar R, Hendel R, Crawley J, Wackers F, Rigo P, Zaret B, Sridhara B, Lahiri A. Improved diagnostic accuracy of planar imaging with technetium 99m-labeled tetrofosmin compared with thallium-201 for the detection of coronary artery disease. Journal Of Nuclear Cardiology 1997, 4: 291-297. PMID: 9278875, DOI: 10.1016/s1071-3581(97)90106-9.Peer-Reviewed Original ResearchConceptsCoronary artery diseaseROC curve analysisPrevious myocardial infarctionArtery diseaseCurve analysisMyocardial infarctionMulticenter phase III trialTechnetium 99m-labeled tetrofosminDiagnostic accuracySingle-vessel diseasePhase III trialsCharacteristic curve analysisMultivessel diseaseIII trialsCoronary arteriographyROC curve areaThallium-201TetrofosminDiagnostic testsDiseaseDiagnostic performanceCurve areaInfarctionReference standardPlanar imaging
1996
Comparison of Nifedipine GITS and Hydrochlorothiazide in the Management of Elderly Patients with Stage I–III Diastolic Hypertension*
Dey H, Soufer R, Hoffer P, Wackers F, Black H. Comparison of Nifedipine GITS and Hydrochlorothiazide in the Management of Elderly Patients with Stage I–III Diastolic Hypertension*. American Journal Of Hypertension 1996, 9: 598-606. PMID: 8783785, DOI: 10.1016/0895-7061(96)00168-9.Peer-Reviewed Original ResearchConceptsNifedipine gastrointestinal therapeutic systemGastrointestinal therapeutic systemDiastolic blood pressureBlood pressureDiastolic hypertensionStage IVentricular massCardiovascular functionTreatment differencesGoal diastolic blood pressureSignificant blood pressure reductionWeek placebo washout phasePlacebo washout phaseWeek maintenance phaseBlood pressure reductionGoal blood pressureDiastolic filling rateRenal blood flowGlomerular filtration rateLeft ventricular massBlood urea nitrogenShort-term therapyAdverse side effectsSignificant adverse effectsDiuretic therapyComparison and reproducibility of visual echocardiographic and quantitative radionyclide left ventricular ejection fractions
van Royen N, Jaffe C, Krumholz H, Johnson K, Lynch P, Natale D, Atkinson P, Demon P, Wackers F. Comparison and reproducibility of visual echocardiographic and quantitative radionyclide left ventricular ejection fractions. The American Journal Of Cardiology 1996, 77: 843-850. PMID: 8623737, DOI: 10.1016/s0002-9149(97)89179-5.Peer-Reviewed Original ResearchConceptsEquilibrium radionuclide angiographyVentricular ejection fractionEjection fractionRadionuclide angiographyEchocardiographic LVEFEquilibrium radionuclideRadionuclide LVEFClinical relevanceLeft ventricular ejection fractionCorrelation of LVEFDetermination of LVEFPatient management decisionsPotential clinical relevanceRelevant differencesInter-observer reproducibilityStable patientsLV functionLimits of agreementLVEFIndividual patientsRepeat assessmentEchocardiographyAngiographyBlinded analysisRepeat analysis
1995
Preoperative Dipyridamole Thallium Imaging and Ambulatory Electrocardiographic Monitoring as a Predictor of Perioperative Cardiac Events and Long-term Outcome
Fleisher L, Rosenbaum S, Nelson A, Jain D, Wackers F, Zaret B. Preoperative Dipyridamole Thallium Imaging and Ambulatory Electrocardiographic Monitoring as a Predictor of Perioperative Cardiac Events and Long-term Outcome. Anesthesiology 1995, 83: 906-917.. PMID: 7486176, DOI: 10.1097/00000542-199511000-00003.Peer-Reviewed Original ResearchMeSH KeywordsAgedAged, 80 and overDipyridamoleElectrocardiography, AmbulatoryFemaleHeart DiseasesHumansIntraoperative ComplicationsMaleMiddle AgedPostoperative ComplicationsPredictive Value of TestsPreoperative CarePrognosisProspective StudiesRadionuclide AngiographySensitivity and SpecificitySurvival AnalysisThallium RadioisotopesVasodilator AgentsConceptsPerioperative cardiac eventsPredictive valueDipyridamole thalliumCardiac eventsPreoperative dipyridamole thallium imagingLong-term cardiac survivalGreatest likelihood ratioNoncardiac surgery patientsPerioperative cardiac morbidityDipyridamole-thallium imagingLong-term mortalityLong-term prognosisAmbulatory electrocardiographic monitoringShort-term outcomesLong-term outcomesLikelihood ratioPositive predictive valueLog-rank statisticsNuclear cardiology laboratoryCardiac morbidityNoncardiac surgerySurgery patientsThallium imagingCardiac survivalElectrocardiographic monitoringMyocardial perfusion imaging with 99mTc tetrofosmin. Comparison to 201Tl imaging and coronary angiography in a phase III multicenter trial. Tetrofosmin International Trial Study Group.
Zaret B, Rigo P, Wackers F, Hendel R, Braat S, Iskandrian A, Sridhara B, Jain D, Itti R, Serafini A, Goris M, Lahiri A. Myocardial perfusion imaging with 99mTc tetrofosmin. Comparison to 201Tl imaging and coronary angiography in a phase III multicenter trial. Tetrofosmin International Trial Study Group. Circulation 1995, 91: 313-9. PMID: 7805233, DOI: 10.1161/01.cir.91.2.313.Peer-Reviewed Original ResearchConceptsCoronary artery diseaseArtery diseaseTetrofosmin imagingCoronary angiographyMyocardial perfusionTetrofosmin imagesHealthy subjectsPhase III multicenter trialConventional myocardial perfusionLower likelihoodCentral core laboratoryMyocardial perfusion abnormalitiesNew 99mTcPeak heart rateNegative predictive accuracyMyocardial perfusion imagingNew myocardial imaging agentPlanar 201TlMulticenter trialNormalcy rateCoronary angiogramDouble productPerfusion abnormalitiesMyocardial imaging agentRadiotracer injection
1994
One-year prognosis of patients with normal planar or single-photon emission computed tomographic technetium 99m-labeled sestamibi exercise imaging
Raiker K, Sinusas A, Wackers F, Zaret B. One-year prognosis of patients with normal planar or single-photon emission computed tomographic technetium 99m-labeled sestamibi exercise imaging. Journal Of Nuclear Cardiology 1994, 1: 449-456. PMID: 9420729, DOI: 10.1007/bf02961599.Peer-Reviewed Original ResearchConceptsNondiagnostic exercise electrocardiogramsPositive exercise electrocardiogramExercise electrocardiogramPrognostic significanceSingle photon emissionHigher cardiac event rateCardiac event rateChest pain syndromeNegative exercise electrocardiogramNonfatal myocardial infarctionOne-year prognosisPositive stress electrocardiogramCoronary artery diseaseFavorable prognostic significanceMyocardial perfusion imagingStress perfusion imagesCardiac causesCardiac eventsPain syndromeArtery diseaseConsecutive patientsExercise SPECTMyocardial infarctionFavorable outcomeStress electrocardiogram
1993
Myocardial risk area defined by technetium-99m sestamibi imaging during percutaneous transluminal coronary angioplasty: Comparison with coronary angiography
Haronian H, Remetz M, Sinusas A, Baron J, Miller H, Cleman M, Zaret B, Wackers F. Myocardial risk area defined by technetium-99m sestamibi imaging during percutaneous transluminal coronary angioplasty: Comparison with coronary angiography. Journal Of The American College Of Cardiology 1993, 22: 1033-1043. PMID: 8409038, DOI: 10.1016/0735-1097(93)90413-u.Peer-Reviewed Original ResearchMeSH KeywordsAdultAgedAged, 80 and overAngioplasty, Balloon, CoronaryClinical ProtocolsCollateral CirculationCoronary AngiographyCoronary DiseaseEvaluation Studies as TopicFemaleHumansMaleMiddle AgedMyocardial InfarctionObserver VariationPredictive Value of TestsPrognosisReproducibility of ResultsRisk FactorsSeverity of Illness IndexTechnetium Tc 99m SestamibiTomography, Emission-Computed, Single-PhotonConceptsMyocardial risk areaCoronary angiographyCoronary angioplastyQuantitative myocardial perfusionMyocardial perfusionMyocardial areaPercutaneous transluminal coronary angioplastyAngiographic risk scoresSmall risk areasTransluminal coronary angioplastyCoronary artery diseaseCoronary artery stenosisInitial myocardial uptakeAngioplasty balloon inflationArtery diseaseLeft anteriorNonperfused areaArtery stenosisCoronary anatomyCoronary arteryBalloon inflationPatient managementMyocardial uptakeRisk scoreAngioplasty
1992
Technetium-99m sestamibi myocardial imaging at rest for assessment of myocardial infarction and first-pass ejection fraction
Boucher C, Wackers F, Zaret B, Mena I. Technetium-99m sestamibi myocardial imaging at rest for assessment of myocardial infarction and first-pass ejection fraction. The American Journal Of Cardiology 1992, 69: 22-27. PMID: 1530901, DOI: 10.1016/0002-9149(92)90670-t.Peer-Reviewed Original ResearchConceptsWall motion abnormalitiesFirst-pass ejection fractionEjection fractionQ-wave infarctsMotion abnormalitiesQ wavesAbnormal TcMyocardial infarctionSestamibi studiesFirst-pass imagingAbility of technetiumVentricular ejection fractionOccurrence of infarctionSestamibi myocardial perfusionPerfusion abnormalitiesWall motionRegional perfusionPosterior infarctsMyocardial perfusionMyocardial segmentsPatientsInfarctionSestamibi imagesProtocol IInfarcts
1991
Thallium-201 for assessment of myocardial viability: Quantitative comparison of 24-hour redistribution imaging with imaging after reinjection at rest
Kayden D, Sigal S, Soufer R, Mattera J, Zaret B, Wackers F. Thallium-201 for assessment of myocardial viability: Quantitative comparison of 24-hour redistribution imaging with imaging after reinjection at rest. Journal Of The American College Of Cardiology 1991, 18: 1480-1486. PMID: 1939949, DOI: 10.1016/0735-1097(91)90678-3.Peer-Reviewed Original ResearchConceptsInjection of thalliumRedistribution imagesDefect reversibilityThallium-201 reinjectionThallium-201 defectsLate redistribution imagingPoor quality studiesDiagnostic informationClinical variablesRedistribution imagingThallium defectsThallium imagesMyocardial viabilityReversible defectsStress imagingThallium-201PatientsBetter diagnostic informationStress testingExercisePresent studyQuality studiesInjectionLate redistributionReinjection
1988
Peak filling rate normalized to mitral stroke volume: A new Doppler echocardiographic filling index validated by radionuclide angiographic techniques
Bowman L, Lee F, Jaffe C, Mattera J, Wackers F, Zaret B. Peak filling rate normalized to mitral stroke volume: A new Doppler echocardiographic filling index validated by radionuclide angiographic techniques. Journal Of The American College Of Cardiology 1988, 12: 937-943. PMID: 3417992, DOI: 10.1016/0735-1097(88)90458-5.Peer-Reviewed Original ResearchConceptsPeak filling rateMitral stroke volumeMean peak filling rateEnd-diastolic volumeStroke volumeFilling indexDoppler echocardiographyNormal patientsFilling velocityEarly peak filling velocityLate filling ratioEarly filling velocityDiastolic filling indexesLeft ventricular fillingTime-velocity integralPeak filling velocityRadionuclide angiographic techniquesFilling rateMitral inflowVentricular fillingMitral leafletEchocardiographic determinationMitral apparatusVelocity integralVentricular volume