2001
Dobutamine-induced augmentation of left ventricular ejection fraction predicts survival of heart failure patients with severe non-ischaemic cardiomyopathy
Ramahi T, Longo M, Cadariu A, Rohlfs K, Slade M, Carolan S, Vallejo E, Wackers F. Dobutamine-induced augmentation of left ventricular ejection fraction predicts survival of heart failure patients with severe non-ischaemic cardiomyopathy. European Heart Journal 2001, 22: 849-856. PMID: 11350094, DOI: 10.1053/euhj.2001.2654.Peer-Reviewed Original ResearchConceptsLeft ventricular ejection fractionVentricular ejection fractionTransplant-free survivalEjection fractionHeart failureVentricular end-diastolic volume indexOverall transplant-free survivalPeak exercise oxygen consumptionSevere non-ischaemic cardiomyopathyEnd-diastolic volume indexFunctional classStrongest prognostic variableChronic heart failureHeart failure patientsPrognosis of patientsNon-ischemic cardiomyopathyExercise oxygen consumptionEquilibrium radionuclide ventriculographyVentriculographic variablesExercise capacityFailure patientsPrognostic valueRadionuclide ventriculographyIntravenous infusionDeltaLVEFLeft ventricular inotropic reserve and right ventricular function predict increase of left ventricular ejection fraction after beta-blocker therapy in nonischemic cardiomyopathy
Ramahi T, Longo M, Cadariu A, Rohlfs K, Carolan S, Engle K, Samady H, Wackers F. Left ventricular inotropic reserve and right ventricular function predict increase of left ventricular ejection fraction after beta-blocker therapy in nonischemic cardiomyopathy. Journal Of The American College Of Cardiology 2001, 37: 818-824. PMID: 11693757, DOI: 10.1016/s0735-1097(00)01162-1.Peer-Reviewed Original ResearchMeSH KeywordsAdrenergic beta-AntagonistsAdultAgedCardiomyopathiesFemaleHumansMaleMiddle AgedRadionuclide VentriculographyStroke VolumeVentricular Function, LeftVentricular Function, RightConceptsLeft ventricular ejection fractionRight ventricular ejection fractionBeta-blocker therapyVentricular ejection fractionVentricular inotropic reserveNonischemic cardiomyopathyEjection fractionInotropic reserveDobutamine infusionLong-term beta-blocker therapyNormal right ventricular ejection fractionImprovement of LVEFBeta-blocker doseRight ventricular functionSystolic blood pressureIntravenous dobutamine infusionEquilibrium radionuclide ventriculographyVentriculographic variablesLVEF increaseBlood pressureVentricular functionRadionuclide ventriculographyUnderwent assessmentIntravenous infusionBaseline variables
1993
Nuclear Cardiology
Zaret B, Wackers F. Nuclear Cardiology. New England Journal Of Medicine 1993, 329: 855-863. PMID: 8355745, DOI: 10.1056/nejm199309163291208.Peer-Reviewed Original ResearchFrequency and significance of right ventricular dysfunction during inferior wall left ventricular myocardial infarction treated with thrombolytic therapy (results from the Thrombolysis in Myocardial Infarction [TIMI] II trial)
Berger P, Ruocco N, Ryan T, Jacobs A, Zaret B, Wackers F, Frederick M, Faxon D, Group R. Frequency and significance of right ventricular dysfunction during inferior wall left ventricular myocardial infarction treated with thrombolytic therapy (results from the Thrombolysis in Myocardial Infarction [TIMI] II trial). The American Journal Of Cardiology 1993, 71: 1148-1152. PMID: 8097614, DOI: 10.1016/0002-9149(93)90637-r.Peer-Reviewed Original ResearchMeSH KeywordsAdrenergic beta-AntagonistsAngioplasty, Balloon, CoronaryCombined Modality TherapyConstriction, PathologicCoronary VesselsFemaleHeart DiseasesHeart VentriclesHumansMaleMiddle AgedMyocardial InfarctionRadionuclide VentriculographyThrombolytic TherapyTissue Plasminogen ActivatorVentricular Function, LeftVentricular Function, RightConceptsRV wall motion abnormalitiesRight ventricular dysfunctionRV dysfunctionVentricular myocardial infarctionWall motion abnormalitiesVentricular dysfunctionThrombolytic therapyRadionuclide ventriculographyMyocardial infarctionMotion abnormalitiesInferior wallLower mean left ventricular ejection fractionMean left ventricular ejection fractionLeft ventricular ejection fractionBaseline clinical characteristicsInfarct-related arteryMyocardial Infarction (TIMI) II trialVentricular ejection fractionEquilibrium radionuclide ventriculographyHospital complicationsMultivessel diseaseII trialClinical characteristicsHospital dischargeEjection fraction
1992
Assessment of global and regional left ventricular performance at rest and during exercise after thrombolytic therapy for acute myocardial infarction: Results of the Thrombolysis in Myocardial Infarction (TIMI) II study
Zaret B, Wackers F, Terrin M, Ross R, Weiss M, Slater J, Morrison J, Bourge R, Passamani E, Knatterud G, Braunwald E, Investigators. Assessment of global and regional left ventricular performance at rest and during exercise after thrombolytic therapy for acute myocardial infarction: Results of the Thrombolysis in Myocardial Infarction (TIMI) II study. The American Journal Of Cardiology 1992, 69: 1-9. PMID: 1729855, DOI: 10.1016/0002-9149(92)90667-n.Peer-Reviewed Original ResearchConceptsLV ejection fractionLeft ventricular performanceEjection fractionRegional left ventricular performanceRegional ejection fractionHospital dischargeThrombolytic therapyVentricular performanceTreatment strategiesStrategies patientsComparable work loadNormal exercise responseRegional LV performanceMyocardial Infarction (TIMI) II trialAcute myocardial infarctionHospital-discharged patientsConservative strategyII studyII trialDischarge patientsConservative patientsClinical benefitLV performanceExercise studiesMyocardial infarction
1991
Validation of continuous radionuclide left ventricular functioning monitoring in detecting silent myocardial ischemia during balloon angioplasty of the left anterior descending coronary artery
Kayden D, Remetz M, Cabin H, Deckelbaum L, Cleman M, Wackers F, Zaret B. Validation of continuous radionuclide left ventricular functioning monitoring in detecting silent myocardial ischemia during balloon angioplasty of the left anterior descending coronary artery. The American Journal Of Cardiology 1991, 67: 1339-1343. PMID: 2042565, DOI: 10.1016/0002-9149(91)90462-t.Peer-Reviewed Original ResearchMeSH KeywordsAgedAngioplasty, Balloon, CoronaryCoronary DiseaseElectrocardiography, AmbulatoryHumansMaleMiddle AgedRadionuclide VentriculographyStroke VolumeVentricular Function, LeftConceptsSilent myocardial ischemiaLV ejection fractionLV dysfunctionMyocardial ischemiaEjection fractionLV functionBalloon inflationRelative end-systolic volumeTransient ST-segment depressionPercutaneous transluminal coronary angioplastyMean LV ejection fractionST-segment depressionContinuous electrocardiographic monitoringTransluminal coronary angioplastyLeft ventricular functionST-segment changesEnd-diastolic volumeEnd-systolic volumeIschemic decreaseCoronary angioplastyVentricular functionElectrocardiographic changesElectrocardiographic monitoringBalloon angioplastyCoronary artery
1990
Comparison of immediate invasive, delayed invasive, and conservative strategies after tissue-type plasminogen activator. Results of the Thrombolysis in Myocardial Infarction (TIMI) Phase II-A trial.
Rogers W, Baim D, Gore J, Brown B, Roberts R, Williams D, Chesebro J, Babb J, Sheehan F, Wackers F. Comparison of immediate invasive, delayed invasive, and conservative strategies after tissue-type plasminogen activator. Results of the Thrombolysis in Myocardial Infarction (TIMI) Phase II-A trial. Circulation 1990, 81: 1457-1476. PMID: 2110033, DOI: 10.1161/01.cir.81.5.1457.Peer-Reviewed Original ResearchMeSH KeywordsAgedAngioplasty, Balloon, CoronaryCombined Modality TherapyCoronary AngiographyCoronary Artery BypassExercise TestFemaleHumansMaleMiddle AgedMyocardial InfarctionRadionuclide VentriculographyRandomized Controlled Trials as TopicStroke VolumeThrombolytic TherapyTime FactorsTissue Plasminogen ActivatorConceptsCoronary artery bypass graft surgeryPercutaneous transluminal coronary angioplastyInvasive strategy groupConservative-strategy groupAcute myocardial infarctionTreatment groupsPrimary study end pointResidual infarct artery stenosisArtery bypass graft surgeryPatent infarct-related arteryImmediate invasive strategyPredischarge exercise testingSimilar cumulative ratesBypass graft surgeryStudy end pointInfarct-related arteryTransluminal coronary angioplastyVentricular ejection fractionInitial management strategyLong-term outcomesConservative strategyStrategy groupTissue-type plasminogen activatorNonfatal reinfarctionGraft surgery