Autonomic dysfunction independently predicts poor cardiovascular outcomes in asymptomatic individuals with type 2 diabetes in the DIAD study
Chyun DA, Wackers FJ, Inzucchi SE, Jose P, Weiss C, Davey JA, Heller GV, Iskandrian AE, Young LH, Investigators F. Autonomic dysfunction independently predicts poor cardiovascular outcomes in asymptomatic individuals with type 2 diabetes in the DIAD study. SAGE Open Medicine 2015, 3: 2050312114568476. PMID: 26770763, PMCID: PMC4679226, DOI: 10.1177/2050312114568476.Peer-Reviewed Original ResearchCardiac autonomic neuropathyHeart rate ratioAdverse cardiac outcomesHigher pulse pressureAutonomic neuropathyType 2 diabetesCardiac outcomesNon-Black ethnicityHeart rate variabilityInsulin useAsymptomatic individualsPulse pressureCardiac diseaseHeart rateRate ratioGreater systolic blood pressure decreasePower spectral analysisSystolic blood pressure decreaseRate variabilityAsymptomatic Diabetics (DIAD) studyAsymptomatic type 2Composite clinical outcomeHigher glycated hemoglobinPoor cardiac outcomesPoor cardiovascular outcomes