2020
Management of Lung Nodules and Lung Cancer Screening During the COVID-19 Pandemic CHEST Expert Panel Report
Mazzone PJ, Gould MK, Arenberg DA, Chen AC, Choi HK, Detterbeck FC, Farjah F, Fong KM, Iaccarino JM, Janes SM, Kanne JP, Kazerooni EA, MacMahon H, Naidich DP, Powell CA, Raoof S, Rivera MP, Tanner NT, Tanoue LK, Tremblay A, Vachani A, White CS, Wiener RS, Silvestri GA. Management of Lung Nodules and Lung Cancer Screening During the COVID-19 Pandemic CHEST Expert Panel Report. Journal Of The American College Of Radiology 2020, 17: 845-854. PMID: 32485147, PMCID: PMC7177099, DOI: 10.1016/j.jacr.2020.04.024.Peer-Reviewed Original ResearchConceptsLung cancer screeningCell lung cancerCancer screeningLung nodule evaluationConsensus statementLung nodulesLung cancerStage INodule evaluationAnnual lung cancer screeningHigh-risk lung nodulesLung cancer screening programsClinical stage ICHEST Expert Panel ReportCurrent guideline recommendationsCancer screening programsPatient-related factorsCommon clinical scenariosCoronavirus disease 2019Balance of benefitsIndividual patient careCOVID-19 pandemicExpert Panel ReportPotential exposureGuideline recommendations
2017
“What if I do nothing?” The natural history of operable cancer of the alimentary tract
Keshava HB, Rosen JE, DeLuzio MR, Kim AW, Detterbeck FC, Boffa DJ. “What if I do nothing?” The natural history of operable cancer of the alimentary tract. European Journal Of Surgical Oncology 2017, 43: 788-795. PMID: 28131669, DOI: 10.1016/j.ejso.2016.12.006.Peer-Reviewed Original ResearchMeSH KeywordsAdenocarcinomaAdultAgedAged, 80 and overCarcinoma, Signet Ring CellCarcinoma, Squamous CellColonic NeoplasmsDatabases, FactualDisease ProgressionEsophageal NeoplasmsFemaleGastrointestinal NeoplasmsHumansMaleMiddle AgedNeoplasm StagingRectal NeoplasmsStomach NeoplasmsSurvival RateUnited StatesWatchful WaitingConceptsAlimentary tract cancersTract cancerNatural historyUntreated patientsCancer surgeryClinical stage IStage-specific survivalOperable cancerInoperable patientsMedian survivalRectal cancerClinical stagePreoperative counselingPatientsStage ISurgeryCancerPoor healthAlimentary tractSurvivalHealth reasonsStudy objectiveTreatmentCIICIII
2016
Defining outcomes of patients with clinical stage I small cell lung cancer upstaged at surgery
Thomas DC, Arnold BN, Rosen JE, Salazar MC, Blasberg JD, Detterbeck FC, Boffa DJ, Kim AW. Defining outcomes of patients with clinical stage I small cell lung cancer upstaged at surgery. Lung Cancer 2016, 103: 75-81. PMID: 28024700, DOI: 10.1016/j.lungcan.2016.11.016.Peer-Reviewed Original ResearchMeSH KeywordsAgedAged, 80 and overCarcinoma, Non-Small-Cell LungChemotherapy, AdjuvantCombined Modality TherapyDatabases, FactualFemaleGuidelines as TopicHumansLung NeoplasmsLymphatic MetastasisMaleMiddle AgedNeoplasm StagingOutcome Assessment, Health CarePneumonectomyPostoperative PeriodRadiotherapySmall Cell Lung CarcinomaSurvival AnalysisConceptsStage I small cell lung cancerClinical stage ISmall cell lung cancerCell lung cancerAdjuvant chemotherapySurgical resectionPathologic upstagingStage IRadiation therapyNodal diseaseLung cancerPositive lymph node involvementNational Cancer DatabaseOutcomes of patientsLymph node involvementProportion of patientsCurative intentNodal upstagingSCLC patientsUpstaged patientsAdjuvant therapyNode involvementIndependent predictorsInferior survivalT descriptorLobectomy versus stereotactic body radiotherapy in healthy patients with stage I lung cancer
Rosen JE, Salazar MC, Wang Z, Yu JB, Decker RH, Kim AW, Detterbeck FC, Boffa DJ. Lobectomy versus stereotactic body radiotherapy in healthy patients with stage I lung cancer. Journal Of Thoracic And Cardiovascular Surgery 2016, 152: 44-54.e9. PMID: 27131846, DOI: 10.1016/j.jtcvs.2016.03.060.Peer-Reviewed Original ResearchConceptsStage I lung cancerStereotactic body radiotherapyI lung cancerNational Cancer DatabaseClinical stage I lung cancerNon-small cell lung cancerCell lung cancerBody radiotherapyHealthy patientsLung cancerCancer DatabaseClinical stage I non-small cell lung cancerStage I non-small cell lung cancerBetter outcomesEarly-stage non-small cell lung cancerPatient healthCox proportional hazards modelComorbidity-free patientsClinical stage IPropensity-matched analysisProportional hazards modelLong-term survivalHealth-related reasonsStereotactic patientsT1N0M0 tumorsThe Natural History of Operable Non-Small Cell Lung Cancer in the National Cancer Database
Rosen JE, Keshava HB, Yao X, Kim AW, Detterbeck FC, Boffa DJ. The Natural History of Operable Non-Small Cell Lung Cancer in the National Cancer Database. The Annals Of Thoracic Surgery 2016, 101: 1850-1855. PMID: 27041452, DOI: 10.1016/j.athoracsur.2016.01.077.Peer-Reviewed Original ResearchConceptsOperable non-small cell lung cancerNon-small cell lung cancerNational Cancer DatabaseUntreated NSCLC patientsClinical stage ICell lung cancerNSCLC patientsNatural historyStage ILung cancerCancer DatabaseUntreated non-small cell lung cancerIIIA non-small cell lung cancerMultivariable Cox regression modelsLarge cell histologyNatural history cohortOperable NSCLC patientsCox regression modelMedian survivalUntreated patientsCell histologyMeier estimatesSurgical resectionClinical stageSquamous cellsDetection of Occult Micrometastases in Patients With Clinical Stage I Non–Small-Cell Lung Cancer: A Prospective Analysis of Mature Results of CALGB 9761 (Alliance)
Martin LW, D'Cunha J, Wang X, Herzan D, Gu L, Abraham N, Demmy TL, Detterbeck FC, Groth SS, Harpole DH, Krasna MJ, Kernstine K, Kohman LJ, Patterson GA, Sugarbaker DJ, Vollmer RT, Maddaus MA, Kratzke RA. Detection of Occult Micrometastases in Patients With Clinical Stage I Non–Small-Cell Lung Cancer: A Prospective Analysis of Mature Results of CALGB 9761 (Alliance). Journal Of Clinical Oncology 2016, 34: 1484-1491. PMID: 26926677, PMCID: PMC4872306, DOI: 10.1200/jco.2015.63.4543.Peer-Reviewed Original ResearchConceptsN2 lymph nodesStage I NSCLCDisease-free survivalOccult micrometastasesLymph nodesCell lung cancerOverall survivalLung cancerStage IClinical stage I NSCLCPathologic stage I NSCLCComplete surgical stagingClinical stage IRT-PCRDecreased overall survivalNegative lymph nodesWorse survival rateSquamous cell carcinomaReal-time reverse transcriptase-polymerase chain reactionMulti-institutional trialReverse transcriptase-polymerase chain reactionTranscriptase-polymerase chain reactionWarrants further investigationSurgical stagingPrognostic significance
2015
Bolstering the Case for Lobectomy in Stages I, II, and IIIA Small-Cell Lung Cancer Using the National Cancer Data Base
Combs SE, Hancock JG, Boffa DJ, Decker RH, Detterbeck FC, Kim AW. Bolstering the Case for Lobectomy in Stages I, II, and IIIA Small-Cell Lung Cancer Using the National Cancer Data Base. Journal Of Thoracic Oncology 2015, 10: 316-323. PMID: 25319182, DOI: 10.1097/jto.0000000000000402.Peer-Reviewed Original ResearchConceptsSmall cell lung cancerNational Cancer Data BaseSurgical resectionStage ISCLC patientsSublobar resectionOverall survivalLung cancerIIIA small cell lung cancerFive-year overall survivalAddition of surgeryClinical stage IPatient underwent surgeryPrimary surgical resectionKaplan-Meier methodLikelihood of deathCurative intentComorbidity scoreUnderwent surgeryChemoradiation therapyHazard ratioMetastatic diseaseMultimodality treatmentSelect patientsTreatment regimen
2014
Fewer complications result from a video-assisted approach to anatomic resection of clinical stage I lung cancer
Boffa DJ, Dhamija A, Kosinski AS, Kim AW, Detterbeck FC, Mitchell JD, Onaitis MW, Paul S. Fewer complications result from a video-assisted approach to anatomic resection of clinical stage I lung cancer. Journal Of Thoracic And Cardiovascular Surgery 2014, 148: 637-643. PMID: 24529729, DOI: 10.1016/j.jtcvs.2013.12.045.Peer-Reviewed Original ResearchMeSH KeywordsAdolescentAdultAgedAged, 80 and overFemaleHumansLogistic ModelsLung NeoplasmsMaleMiddle AgedMultivariate AnalysisNeoplasm StagingOdds RatioPneumonectomyPostoperative ComplicationsPropensity ScoreRisk FactorsThoracic Surgery, Video-AssistedThoracotomyTime FactorsTreatment OutcomeYoung AdultConceptsStage I lung cancerClinical stage I lung cancerI lung cancerThoracic Surgeons databaseAnatomic resectionLung cancerSurgeons databaseStage I primary lung cancerVideo-assisted thoracic surgery approachEarly-stage lung cancerMore pulmonary complicationsClinical stage ILung cancer resectionPrimary lung cancerMorbidity of patientsThoracic surgery approachStage lung cancerStandard of careMorbidity of thoracotomyVideo-assisted approachLower mortality rateOverall complicationsPulmonary complicationsThoracotomy groupVATS cohort
2008
Assessing quality of life following neoadjuvant therapy for early stage non-small cell lung cancer (NSCLC): results from a prospective analysis using the Lung Cancer Symptom Scale (LCSS)
Gralla RJ, Edelman MJ, Detterbeck FC, Jahan TM, Loesch DM, Limentani SA, Govindan R, Peng G, Monberg MJ, Obasaju CK, Socinski MA. Assessing quality of life following neoadjuvant therapy for early stage non-small cell lung cancer (NSCLC): results from a prospective analysis using the Lung Cancer Symptom Scale (LCSS). Supportive Care In Cancer 2008, 17: 307-313. PMID: 18781341, DOI: 10.1007/s00520-008-0489-y.Peer-Reviewed Original ResearchConceptsLung Cancer Symptom ScaleNon-small cell lung cancerQuality of lifeCancer Symptom ScaleCell lung cancerNeoadjuvant therapyPostsurgical evaluationLung cancerSymptom ScaleEarly-stage non-small cell lung cancerStage non-small cell lung cancerClinical stage IECOG performance statusSubgroup of patientsModalities of treatmentSignificant survival gainStable QOLConclusionsMost patientsNeoadjuvant trialsAdjuvant approachPerformance statusPreoperative chemotherapyComplete resectionStable symptomsSurvival gain