1987
Thymic hypoplasia, splenomegaly and immune depression in guinea pigs with neonatal cytomegalovirus infection
Zheng Z, Lavallee J, Bia F, Griffith B. Thymic hypoplasia, splenomegaly and immune depression in guinea pigs with neonatal cytomegalovirus infection. Developmental & Comparative Immunology 1987, 11: 407-418. PMID: 3040485, DOI: 10.1016/0145-305x(87)90084-x.Peer-Reviewed Original ResearchConceptsGuinea pigsCMV infectionCytomegalovirus infectionThymic hypoplasiaProliferative responseImmune proliferative responsesNeonatal cytomegalovirus infectionAcute CMV infectionT lymphocyte populationsNeonatal guinea pigsT cell mitogensConcanavalin AB cell mitogensImmunodepressive effectImmune depressionLymphocyte populationsSpleen cellsInfectious virusGrowth retardationDissimilar alterationsHigh titersSpleenInfectionThymusSplenomegaly
1985
Effects of Cyclosporine on the Pathogenesis of Primary Cytomegalovirus Infection in the Guinea Pig
Bia F, Lucia H, Bia M, Vine W, Tuttle A. Effects of Cyclosporine on the Pathogenesis of Primary Cytomegalovirus Infection in the Guinea Pig. Intervirology 1985, 24: 154-165. PMID: 2999030, DOI: 10.1159/000149635.Peer-Reviewed Original ResearchConceptsPrimary cytomegalovirus infectionGuinea pigsCytomegalovirus infectionPrimary CMV infectionEffect of cyclosporinePresence of CMVGuinea pig CMVGuinea pig modelInternal organsHartley guinea pigsTotal body weightUntreated controlsCMV isolationOral CsACMV infectionCsA administrationLymphocyte valuesLymphocytes/Inflammatory responseMean changeViral inclusionsBody weightPig modelDay 0CMV