1987
Thymic hypoplasia, splenomegaly and immune depression in guinea pigs with neonatal cytomegalovirus infection
Zheng Z, Lavallee J, Bia F, Griffith B. Thymic hypoplasia, splenomegaly and immune depression in guinea pigs with neonatal cytomegalovirus infection. Developmental & Comparative Immunology 1987, 11: 407-418. PMID: 3040485, DOI: 10.1016/0145-305x(87)90084-x.Peer-Reviewed Original ResearchConceptsGuinea pigsCMV infectionCytomegalovirus infectionThymic hypoplasiaProliferative responseImmune proliferative responsesNeonatal cytomegalovirus infectionAcute CMV infectionT lymphocyte populationsNeonatal guinea pigsT cell mitogensConcanavalin AB cell mitogensImmunodepressive effectImmune depressionLymphocyte populationsSpleen cellsInfectious virusGrowth retardationDissimilar alterationsHigh titersSpleenInfectionThymusSplenomegalyEffects of Cyclosporine on Chronic Cytomegalovirus Infection in the Guinea Pig
Markham D, Griffith B, Lerner E, Lucia H, Bia F. Effects of Cyclosporine on Chronic Cytomegalovirus Infection in the Guinea Pig. Intervirology 1987, 28: 171-180. PMID: 2836336, DOI: 10.1159/000150013.Peer-Reviewed Original ResearchConceptsCytomegalovirus infectionLymphoid tissueGuinea pig cytomegalovirus infectionDetectable systemic diseaseGPCMV-infected animalsChronic cytomegalovirus infectionEffect of cyclosporineCMV isolationImmunosuppressed groupSystemic diseaseGuinea pigsExperimental animalsCs immunosuppressionCyclosporineIsolation rateDrug vehicleInfectionTissueAnimalsImmunosuppressionGavageDisease
1986
Effects of Cyclosporine and Cortisone on the Pathogenesis of Primary Infection with Cytomegalovirus in the Guinea Pig
MacGregor M, Lucia H, Vine W, FitzGerald P, Bia F. Effects of Cyclosporine and Cortisone on the Pathogenesis of Primary Infection with Cytomegalovirus in the Guinea Pig. The Journal Of Infectious Diseases 1986, 153: 503-510. PMID: 3005426, DOI: 10.1093/infdis/153.3.503.Peer-Reviewed Original ResearchConceptsPrimary infectionGuinea pigsTissue culture infectious dosesEffect of cyclosporineGuinea pig modelRate of isolationGuinea pig cytomegalovirusOral CsAImmunosuppressive agentsInflammatory responseInfectious dosesViral inclusionsPig modelDay 14Day 0CortisoneCytomegalovirusMinimal inflammatory responseCsALymphopeniaPathogenesisInfectionUntreated controlsAnimalsTissue
1985
Pulmonary macrophage function during experimental cytomegalovirus interstitial pneumonia
Miller S, Bia F, Coleman D, Lucia H, Young K, Root R. Pulmonary macrophage function during experimental cytomegalovirus interstitial pneumonia. Infection And Immunity 1985, 47: 211-216. PMID: 2981196, PMCID: PMC261498, DOI: 10.1128/iai.47.1.211-216.1985.Peer-Reviewed Original ResearchConceptsPulmonary macrophagesInterstitial pneumoniaCytomegalovirus interstitial pneumoniaMacrophage oxidative functionTissue culture infective dosesH2O2 releaseCMV interstitial pneumoniaPulmonary macrophage functionGuinea pig CMVSalivary gland suspensionsBuffy coat cellsBone marrow cellsPhorbol myristate acetateO2 consumptionCMV pneumoniaPulmonary granulocytesCytomegalovirus infectionVariety of pathogensWhole lungControl animalsPulmonary lavageUninfected controlsMacrophage functionVirus isolationDay 7Effects of Cyclosporine on the Pathogenesis of Primary Cytomegalovirus Infection in the Guinea Pig
Bia F, Lucia H, Bia M, Vine W, Tuttle A. Effects of Cyclosporine on the Pathogenesis of Primary Cytomegalovirus Infection in the Guinea Pig. Intervirology 1985, 24: 154-165. PMID: 2999030, DOI: 10.1159/000149635.Peer-Reviewed Original ResearchConceptsPrimary cytomegalovirus infectionGuinea pigsCytomegalovirus infectionPrimary CMV infectionEffect of cyclosporinePresence of CMVGuinea pig CMVGuinea pig modelInternal organsHartley guinea pigsTotal body weightUntreated controlsCMV isolationOral CsACMV infectionCsA administrationLymphocyte valuesLymphocytes/Inflammatory responseMean changeViral inclusionsBody weightPig modelDay 0CMV
1984
Vaccination Against Transplacental Cytomegalovirus Transmission: Vaccine Reactivation and Efficacy in Guinea Pigs
Bia F, Miller S, Lucia H, Griffith B, Tarsio M, Hsiung G. Vaccination Against Transplacental Cytomegalovirus Transmission: Vaccine Reactivation and Efficacy in Guinea Pigs. The Journal Of Infectious Diseases 1984, 149: 355-362. PMID: 6325549, DOI: 10.1093/infdis/149.3.355.Peer-Reviewed Original ResearchConceptsCMV infectionSubsequent pregnancyThroat swabsCMV transmissionGuinea pigsNonpregnant control animalsCongenital CMV infectionTissue culture infective dosesHartley strain guinea pigsGuinea pig modelCMV vaccineCytomegalovirus transmissionCytomegalovirus infectionFetal infectionPregnant controlsAcute viremiaGeneralized infectionCytomegalovirus vaccineControl animalsInfective dosesPregnancyPregnant animalsVaccineInfectionSwabs
1983
Histopathologic and ultrastructural studies of disseminated cytomegalovirus infection in strain 2 guinea pigs.
Fong C, Lucia H, Bia F, Hsiung G. Histopathologic and ultrastructural studies of disseminated cytomegalovirus infection in strain 2 guinea pigs. Laboratory Investigation 1983, 49: 183-94. PMID: 6308346.Peer-Reviewed Original ResearchMeSH KeywordsAnimalsBrainCytomegalovirus InfectionsFemaleGuinea PigsKidneyLiverLungMaleSalivary GlandsSpleenConceptsStrain 2 guinea pigsGuinea pigsCytomegalovirus infectionSalivary glandsViral inclusionsCultured guinea pig cellsGuinea pig cytomegalovirus infectionDisseminated cytomegalovirus infectionSevere disseminated diseaseHigh mortality rateUseful animal modelGland duct cellsSalivary gland duct cellsDisseminated diseaseGuinea pig cellsHistologic examinationElectron microscopic examinationAnimal modelsMortality rateVirus inoculationGross lesionsInfectious virusVisceral tissuesPig cellsIntranuclear inclusionsCytomegaloviral Infections in the Guinea Pig: Experimental Models for Human Disease
Bia F, Griffith B, Fong C, Hsiung G. Cytomegaloviral Infections in the Guinea Pig: Experimental Models for Human Disease. Clinical Infectious Diseases 1983, 5: 177-195. PMID: 6302812, DOI: 10.1093/clinids/5.2.177.Peer-Reviewed Original ResearchConceptsGuinea pig cytomegalovirusInterstitial pneumoniaTransplacental transmissionGuinea pigsPrimary CMV infectionPolymorphonuclear leukocyte functionGuinea pig modelSalivary gland virusHuman viral infectionsCongenital infectionCytomegaloviral infectionCMV infectionBlood transfusionFungal superinfectionsViremic infectionAntigen vaccineTransmission of virusesSuch vaccinesLeukocyte functionHuman diseasesCocultivation techniquesViral infectionPig modelCytomegalovirusInfectious diseases
1982
Effects of Vaccination on Cytomegalovirus-Associated Interstitial Pneumonia in Strain 2 Guinea Pigs
Bia F, Lucia H, Fong C, Tarsio M, Hsiung G. Effects of Vaccination on Cytomegalovirus-Associated Interstitial Pneumonia in Strain 2 Guinea Pigs. The Journal Of Infectious Diseases 1982, 145: 742-747. PMID: 6281341, DOI: 10.1093/infdis/145.2.742.Peer-Reviewed Original ResearchConceptsStrain 2 guinea pigsInterstitial pneumoniaCMV infectionGuinea pigsMinimal histopathologic changesTissue culture infective dosesBilateral interstitial pneumoniaEffect of vaccinationStudy of pathogenesisGuinea pig cytomegalovirusHistologic evidenceHistopathologic changesPneumoniaVaccinated animalsInfective dosesCytomegalovirusInfectionLungInfected tissuesPathogenesisPigsTissuePreventionAnimalsViremiaNeutrophil response and function during acute cytomegalovirus infection in guinea pigs
Yourtee E, Bia F, Griffith B, Root R. Neutrophil response and function during acute cytomegalovirus infection in guinea pigs. Infection And Immunity 1982, 36: 11-16. PMID: 6281184, PMCID: PMC351177, DOI: 10.1128/iai.36.1.11-16.1982.Peer-Reviewed Original ResearchConceptsAcute cytomegalovirus infectionTissue culture infective dosesCytomegalovirus infectionPolymorphonuclear leukocytesGuinea pig cytomegalovirusPeritoneal polymorphonuclear leukocytesGuinea pigsInfected animalsInflammatory stimuliUninfected controlsInfective dosesHartley strain guinea pigsType of infectionPhorbol myristate acetateAcute infectionGranulocyte numbersNeutrophil responseCasein injectionNeutrophil activatorInflammatory sitesBacterial stimuliControl animalsBone marrowDecreased mobilizationBacterial killing
1981
Cytomegalovirus-induced mononucleosis in guinea pigs
Griffith B, Lucia H, Bia F, Hsiung G. Cytomegalovirus-induced mononucleosis in guinea pigs. Infection And Immunity 1981, 32: 857-863. PMID: 6265366, PMCID: PMC351522, DOI: 10.1128/iai.32.2.857-863.1981.Peer-Reviewed Original ResearchConceptsGuinea pigsAcute infectionLymphoid tissueBone marrowB-lymphocyte-enriched populationsTransient hematological changesB-cell areasCMV mononucleosisAtypical lymphocytesCMV infectionCytomegalovirus infectionLymph nodesBlood countMononuclear cellsChronic infectionSpleen sizeHematological changesSplenic macrophagesVirus persistenceVirus inoculationInfectionBlood parametersVirus distributionMononucleosisSpleen
1980
Vaccination for the Prevention of Maternal and Fetal Infection with Guinea Pig Cytomegalovirus
Bia F, Griffith B, Tarsio M, Hsiung G. Vaccination for the Prevention of Maternal and Fetal Infection with Guinea Pig Cytomegalovirus. The Journal Of Infectious Diseases 1980, 142: 732-738. PMID: 6257798, DOI: 10.1093/infdis/142.5.732.Peer-Reviewed Original ResearchConceptsFetal infectionAcute viremiaPregnant animalsGuinea pigsGuinea pig cytomegalovirusCMV vaccineAntigen vaccineNonimmune controlsCytomegalovirus vaccineLower incidenceControl animalsImmunized animalsVaccinated animalsCMVViremiaVaccineVirulent virusInfectionSerial passageAnimalsPigsDense bodiesTissue cultureVaccinationCytomegalovirusNew endogenous herpesvirus of guinea pigs: biological and molecular characterization
Bia F, Summers W, Fong C, Hsiung G. New endogenous herpesvirus of guinea pigs: biological and molecular characterization. Journal Of Virology 1980, 36: 245-253. PMID: 6255209, PMCID: PMC353635, DOI: 10.1128/jvi.36.1.245-253.1980.Peer-Reviewed Original ResearchConceptsGuinea pig herpes-like virusGuinea pig cytomegalovirusGuinea pigsStrain 2 guinea pigsCharacteristic cytopathic effectViral DNACross-neutralization testsVirus-infected cellsGuinea pig cellsRestriction endonuclease cleavage analysisCytopathic effectHerpes-like virusPig cellsHerpesvirusFibroblastic cellsPigsImmunoferritin electron microscopyVirusDistinct patternsCellsEndogenous herpesvirusesMolecular characterizationCytomegalovirusLeukocytesViruses of guinea pigs: considerations for biomedical research.
Hsiung G, Bia F, Fong C. Viruses of guinea pigs: considerations for biomedical research. Microbiology And Molecular Biology Reviews 1980, 44: 468-90. PMID: 6252434, PMCID: PMC373189, DOI: 10.1128/mr.44.3.468-490.1980.Peer-Reviewed Reviews, Practice Guidelines, Standards, and Consensus StatementsUltrastructural development and persistence of guinea pig cytomegalovirus in duct cells of guinea pig submaxillary gland
Fong C, Bia F, Hsiung G. Ultrastructural development and persistence of guinea pig cytomegalovirus in duct cells of guinea pig submaxillary gland. Archives Of Virology 1980, 64: 97-108. PMID: 6247997, DOI: 10.1007/bf01318013.Peer-Reviewed Original Research
1979
Cytomegalovirus Infection in Guinea Pigs. III. Persistent Viruria, Blood Transmission, and Viral Interference
Bia F, Hastings K, Hsiung G. Cytomegalovirus Infection in Guinea Pigs. III. Persistent Viruria, Blood Transmission, and Viral Interference. The Journal Of Infectious Diseases 1979, 140: 914-920. PMID: 232118, DOI: 10.1093/infdis/140.6.914.Peer-Reviewed Original ResearchConceptsStrain 2 animalsStrain 2 guinea pigsHerpes-like virusBuffy coatGuinea pig herpes-like virusInfected guinea pigsInbred strain 2 guinea pigsCytomegalovirus infectionBlood recipientsGuinea pigsExperimental CMV infectionsIsolation of cytomegalovirusChronic persistent infectionPigsActive cytomegalovirusUninfected donorsCytomegalovirusPersistent infectionRenal tissueSalivary glandsEndogenous virusInfectious virusViruriaVirusInfectionUltrastructural Development of Guinea Pig Cytomegalovirus in Cultured Guinea Pig Embryo Cells
Fong C, Bia F, Hsiung G, Madore P, Chang P. Ultrastructural Development of Guinea Pig Cytomegalovirus in Cultured Guinea Pig Embryo Cells. Journal Of General Virology 1979, 42: 127-140. PMID: 215704, DOI: 10.1099/0022-1317-42-1-127.Peer-Reviewed Original ResearchConceptsGuinea pig cytomegalovirusUltrastructural developmentInner nuclear membraneNucleus of virusEmbryo cellsVirus capsidNuclear poresDense bodiesCytoplasmic membraneNuclear membraneImmunoelectron microscopyCytoplasmVirus nucleocapsidsCapsidNucleocapsidsVirionsCellsCultured guinea pig embryo (GPE) cellsMembraneGuinea pig embryo cellsNucleusSimilar mannerIntranuclear inclusionsTubular structures