Thymic hypoplasia, splenomegaly and immune depression in guinea pigs with neonatal cytomegalovirus infection
Zheng Z, Lavallee J, Bia F, Griffith B. Thymic hypoplasia, splenomegaly and immune depression in guinea pigs with neonatal cytomegalovirus infection. Developmental & Comparative Immunology 1987, 11: 407-418. PMID: 3040485, DOI: 10.1016/0145-305x(87)90084-x.Peer-Reviewed Original ResearchConceptsGuinea pigsCMV infectionCytomegalovirus infectionThymic hypoplasiaProliferative responseImmune proliferative responsesNeonatal cytomegalovirus infectionAcute CMV infectionT lymphocyte populationsNeonatal guinea pigsT cell mitogensConcanavalin AB cell mitogensImmunodepressive effectImmune depressionLymphocyte populationsSpleen cellsInfectious virusGrowth retardationDissimilar alterationsHigh titersSpleenInfectionThymusSplenomegaly