2020
First-in-Human Experience With Peritoneal Direct Sodium Removal Using a Zero-Sodium Solution
Rao VS, Turner JM, Griffin M, Mahoney D, Asher J, Jeon S, Yoo PS, Boutagy N, Feher A, Sinusas A, Wilson FP, Finkelstein F, Testani JM. First-in-Human Experience With Peritoneal Direct Sodium Removal Using a Zero-Sodium Solution. Circulation 2020, 141: 1043-1053. PMID: 31910658, PMCID: PMC7331276, DOI: 10.1161/circulationaha.119.043062.Peer-Reviewed Original ResearchConceptsStandard PD solutionExperimental heart failureHeart failurePD solutionsAdverse eventsPeritoneal dialysisSignificant discomfortSodium removalEnd-stage renal diseaseEnd pointElevated right atrial pressureMaintenance of euvolemiaPrimary end pointSecondary end pointsRight atrial pressureHuman proofLoss of responseSolute removalPorcine experimentsAtrial pressureRenal diseaseLoop diureticsSerum electrolytesHuman studiesPeritoneal membrane
2019
Patient-Reported Outcome Measures for Adults With Kidney Disease: Current Measures, Ongoing Initiatives, and Future Opportunities for Incorporation Into Patient-Centered Kidney Care
Nair D, Wilson FP. Patient-Reported Outcome Measures for Adults With Kidney Disease: Current Measures, Ongoing Initiatives, and Future Opportunities for Incorporation Into Patient-Centered Kidney Care. American Journal Of Kidney Diseases 2019, 74: 791-802. PMID: 31492487, PMCID: PMC6875620, DOI: 10.1053/j.ajkd.2019.05.025.Peer-Reviewed Reviews, Practice Guidelines, Standards, and Consensus StatementsConceptsPatient-reported outcome measuresHealth care policyKidney diseaseClinical trialsOutcome measuresClinical careCare policyPerception of diseaseLaboratory markersPatient's symptomsKidney carePatient experienceNephrology communityPatient voiceNarrative overviewDiseaseCareSymptomsTrialsAdultsOngoing initiativesNephrologistsPatientsClinicians
2017
Association of Alternative Approaches to Normalizing Peritoneal Dialysis Clearance with Mortality and Technique Failure: A Retrospective Analysis Using the United States Renal Data System-Dialysis Morbidity and Mortality Study, Wave 2
Boyle SM, Li Y, Wilson FP, Glickman JD, Feldman HI. Association of Alternative Approaches to Normalizing Peritoneal Dialysis Clearance with Mortality and Technique Failure: A Retrospective Analysis Using the United States Renal Data System-Dialysis Morbidity and Mortality Study, Wave 2. Advances In Peritoneal Dialysis 2017, 37: 85-93. PMID: 27680757, PMCID: PMC5448711, DOI: 10.3747/pdi.2015.00227.Peer-Reviewed Original ResearchMeSH KeywordsAdultAgedBlood Urea NitrogenCause of DeathCohort StudiesCreatinineDialysis SolutionsFemaleHumansKaplan-Meier EstimateKidney Failure, ChronicKidney Function TestsMaleMiddle AgedPeritoneal Dialysis, Continuous AmbulatoryProportional Hazards ModelsRegistriesRenal DialysisRetrospective StudiesRisk AssessmentSurvival AnalysisUnited StatesUreaConceptsKt/body surface areaKt/VBody surface areaTechnique failureHarrell's C-statisticPeritoneal urea clearanceC-statisticHazard ratioUrea clearanceUrine volumeUnited States Renal Data System Dialysis MorbidityBody mass index strataMortality Study Wave 2Peritoneal Kt/VUnited States Renal Data SystemIncident peritoneal dialysis patientsIdeal weightSignificant differencesCox proportional hazards modelPeritoneal dialysis clearanceMedian patient ageRetrospective cohort studyPeritoneal dialysis patientsGlomerular filtration rateOutcomes of mortality
2016
Lifetime Probabilities of ESRD: A Decade of Disparity
Grams ME, Wilson FP. Lifetime Probabilities of ESRD: A Decade of Disparity. American Journal Of Kidney Diseases 2016, 68: 831-832. PMID: 27884278, DOI: 10.1053/j.ajkd.2016.09.006.Commentaries, Editorials and LettersUrine biomarkers of tubular injury do not improve on the clinical model predicting chronic kidney disease progression
Hsu CY, Xie D, Waikar SS, Bonventre JV, Zhang X, Sabbisetti V, Mifflin TE, Coresh J, Diamantidis CJ, He J, Lora CM, Miller ER, Nelson RG, Ojo AO, Rahman M, Schelling JR, Wilson FP, Kimmel PL, Feldman HI, Vasan RS, Liu KD, Investigators C, Appel L, Feldman H, Go A, He J, Kusek J, Lash J, Ojo A, Rahman M, Townsend R, Consortium C. Urine biomarkers of tubular injury do not improve on the clinical model predicting chronic kidney disease progression. Kidney International 2016, 91: 196-203. PMID: 28029431, PMCID: PMC5362331, DOI: 10.1016/j.kint.2016.09.003.Peer-Reviewed Original ResearchMeSH KeywordsAcetylglucosaminidaseAgedAlbuminuriaBiomarkersCreatinineDisease ProgressionFatty Acid-Binding ProteinsFemaleFollow-Up StudiesGlomerular Filtration RateHepatitis A Virus Cellular Receptor 1HumansKidney Failure, ChronicKidney TubulesLipocalin-2MaleMiddle AgedProportional Hazards ModelsProspective StudiesRenal Insufficiency, ChronicRisk AssessmentRisk FactorsConceptsGlomerular filtration rateUrinary albumin/creatinine ratioAlbumin/creatinine ratioKidney disease progressionTubular injury biomarkersCKD progressionInjury biomarkersFiltration rateClinical modelSerum creatinineCreatinine ratioDisease progressionProspective Chronic Renal Insufficiency Cohort StudyChronic Renal Insufficiency Cohort (CRIC) StudyIncident end-stage renal diseaseUnadjusted Cox proportional hazards modelUrinary kidney injury molecule-1Renal tubular injury biomarkersChronic kidney disease progressionKidney injury molecule-1End-stage renal diseaseNeutrophil gelatinase-associated lipocalinCox proportional hazards modelBase clinical modelInjury molecule-1
2015
Drugs, Dialysis, Decisions, and Data: A Walk through the Minefield of Nephropharmacology
Wilson F, Nolin T, Berns J. Drugs, Dialysis, Decisions, and Data: A Walk through the Minefield of Nephropharmacology. Seminars In Dialysis 2015, 28: 323-324. PMID: 25929704, DOI: 10.1111/sdi.12390.Commentaries, Editorials and LettersPharmacologic Treatment of Common Symptoms in Dialysis Patients: A Narrative Review
Moledina DG, Perry Wilson F. Pharmacologic Treatment of Common Symptoms in Dialysis Patients: A Narrative Review. Seminars In Dialysis 2015, 28: 377-383. PMID: 25913502, DOI: 10.1111/sdi.12378.Peer-Reviewed Reviews, Practice Guidelines, Standards, and Consensus StatementsConceptsTreatment of fatigueCommon symptomsEnd-stage renal disease patientsRenal disease patientsAnabolic steroid nandroloneDisease-related symptomsEvidence-based guidelinesEfficacy of drugsPharmacologic treatmentDialysis patientsCreatine supplementationDisease patientsTreatment decisionsHemodialysis experienceReduced qualityPatientsNarrative reviewSomatic symptomsSymptomsCrampsESRDTreatmentInsomniaTherapyHeavy burden
2014
Urinary Creatinine Excretion, Bioelectrical Impedance Analysis, and Clinical Outcomes in Patients with CKD: The CRIC Study
Wilson FP, Xie D, Anderson AH, Leonard MB, Reese PP, Delafontaine P, Horwitz E, Kallem R, Navaneethan S, Ojo A, Porter AC, Sondheimer JH, Sweeney HL, Townsend RR, Feldman HI, Investigators T. Urinary Creatinine Excretion, Bioelectrical Impedance Analysis, and Clinical Outcomes in Patients with CKD: The CRIC Study. Clinical Journal Of The American Society Of Nephrology 2014, 9: 2095-2103. PMID: 25381342, PMCID: PMC4255402, DOI: 10.2215/cjn.03790414.Peer-Reviewed Original ResearchConceptsLow urinary creatinine excretionUrinary creatinine excretionFat-free massChronic Renal Insufficiency CohortBioelectrical impedance analysisAppendicular lean massClinical outcomesCreatinine excretionLean massSerum cystatin C levelsCox proportional hazards modelLow muscle massChronic disease statesCystatin C levelsDual-energy X-ray absorptiometry assessmentDual-energy X-ray absorptiometry measurementsProportional hazards modelOutcomes of interestCohort of individualsUrinary urea nitrogenCRIC participantsCRIC StudyBlack raceESRDHazards model
2012
Low Cefepime Concentrations during High Blood and Dialysate Flow Continuous Venovenous Hemodialysis
Wilson FP, Bachhuber MA, Caroff D, Adler R, Fish D, Berns J. Low Cefepime Concentrations during High Blood and Dialysate Flow Continuous Venovenous Hemodialysis. Antimicrobial Agents And Chemotherapy 2012, 56: 2178-2180. PMID: 22290968, PMCID: PMC3318326, DOI: 10.1128/aac.05987-11.Peer-Reviewed Original ResearchMeSH KeywordsAdultAnti-Bacterial AgentsCefepimeCephalosporinsChromatography, High Pressure LiquidFemaleHalf-LifeHemofiltrationHumansKidney Failure, ChronicKidney Tubular Necrosis, AcuteMaleMicrobial Sensitivity TestsMiddle AgedPseudomonas aeruginosaShock, CardiogenicSpectrophotometry, UltravioletYoung Adult
2011
Vancomycin levels are frequently subtherapeutic during continuous venovenous hemodialysis (CVVHD)
Wilson FP, Berns JS. Vancomycin levels are frequently subtherapeutic during continuous venovenous hemodialysis (CVVHD). Clinical Nephrology 2011, 77: 329-331. PMID: 22445477, PMCID: PMC3359699, DOI: 10.5414/cn106993.Peer-Reviewed Original ResearchConceptsContinuous renal replacement therapyContinuous venovenous hemodialysisAcute kidney injuryRenal replacement therapyPopulation of patientsDialysis flow rateKidney injuryVancomycin levelsIntensive careReplacement therapyIntermittent dialysisSubtherapeutic levelsLow bloodNephrology traineesAntibioticsHemodialysisPatientsInjuryTherapyPopulationVancomycinBloodDialysisCare