2021
Subtyping CKD Patients by Consensus Clustering: The Chronic Renal Insufficiency Cohort (CRIC) Study
Zheng Z, Waikar SS, Schmidt IM, Landis JR, Hsu CY, Shafi T, Feldman HI, Anderson AH, Wilson FP, Chen J, Rincon-Choles H, Ricardo AC, Saab G, Isakova T, Kallem R, Fink JC, Rao PS, Xie D, Yang W, Investigators C. Subtyping CKD Patients by Consensus Clustering: The Chronic Renal Insufficiency Cohort (CRIC) Study. Journal Of The American Society Of Nephrology 2021, 32: 639-653. PMID: 33462081, PMCID: PMC7920178, DOI: 10.1681/asn.2020030239.Peer-Reviewed Original ResearchConceptsChronic Renal Insufficiency Cohort (CRIC) StudyClinical end pointsKidney function markersCKD subgroupsBaseline characteristicsCohort studyFunction markersCardiovascular diseaseProspective Chronic Renal Insufficiency Cohort StudyEnd pointBaseline kidney functionPatient baseline characteristicsImportant clinical outcomesBone mineral densityPrecision medicineMultiple underlying causesDifferent risksDifferent risk profilesCKD patientsCKD progressionMore medicationsComposite outcomeClinical outcomesKidney functionAdverse outcomes
2018
Attributable Risk and Time Course of Colistin-Associated Acute Kidney Injury
Miano TA, Lautenbach E, Wilson FP, Guo W, Borovskiy Y, Hennessy S. Attributable Risk and Time Course of Colistin-Associated Acute Kidney Injury. Clinical Journal Of The American Society Of Nephrology 2018, 13: 542-550. PMID: 29545383, PMCID: PMC5969457, DOI: 10.2215/cjn.06980717.Peer-Reviewed Original ResearchConceptsBaseline hemoglobin concentrationAKI riskAttributable riskHours of exposureHemoglobin concentrationEquation Poisson regression modelsGlobal Outcomes creatinine criteriaIncidence of AKIAcute kidney injuryRetrospective cohort studyPropensity-matched pairsSimilar baseline characteristicsEarly treatment decisionsIncidence rate ratiosBroad-spectrum antibioticsHours of treatmentPoisson regression modelsColistin groupColistin toxicityHospital mortalityCreatinine criteriaKidney injuryBaseline characteristicsCohort studyKidney function
2017
Association of Alternative Approaches to Normalizing Peritoneal Dialysis Clearance with Mortality and Technique Failure: A Retrospective Analysis Using the United States Renal Data System-Dialysis Morbidity and Mortality Study, Wave 2
Boyle SM, Li Y, Wilson FP, Glickman JD, Feldman HI. Association of Alternative Approaches to Normalizing Peritoneal Dialysis Clearance with Mortality and Technique Failure: A Retrospective Analysis Using the United States Renal Data System-Dialysis Morbidity and Mortality Study, Wave 2. Advances In Peritoneal Dialysis 2017, 37: 85-93. PMID: 27680757, PMCID: PMC5448711, DOI: 10.3747/pdi.2015.00227.Peer-Reviewed Original ResearchMeSH KeywordsAdultAgedBlood Urea NitrogenCause of DeathCohort StudiesCreatinineDialysis SolutionsFemaleHumansKaplan-Meier EstimateKidney Failure, ChronicKidney Function TestsMaleMiddle AgedPeritoneal Dialysis, Continuous AmbulatoryProportional Hazards ModelsRegistriesRenal DialysisRetrospective StudiesRisk AssessmentSurvival AnalysisUnited StatesUreaConceptsKt/body surface areaKt/VBody surface areaTechnique failureHarrell's C-statisticPeritoneal urea clearanceC-statisticHazard ratioUrea clearanceUrine volumeUnited States Renal Data System Dialysis MorbidityBody mass index strataMortality Study Wave 2Peritoneal Kt/VUnited States Renal Data SystemIncident peritoneal dialysis patientsIdeal weightSignificant differencesCox proportional hazards modelPeritoneal dialysis clearanceMedian patient ageRetrospective cohort studyPeritoneal dialysis patientsGlomerular filtration rateOutcomes of mortality
2014
Dialysis versus Nondialysis in Patients with AKI: A Propensity-Matched Cohort Study
Wilson FP, Yang W, Machado CA, Mariani LH, Borovskiy Y, Berns JS, Feldman HI. Dialysis versus Nondialysis in Patients with AKI: A Propensity-Matched Cohort Study. Clinical Journal Of The American Society Of Nephrology 2014, 9: 673-681. PMID: 24651073, PMCID: PMC3974360, DOI: 10.2215/cjn.07630713.Peer-Reviewed Original ResearchMeSH KeywordsAcute Kidney InjuryAdultAgedBiomarkersCreatinineFemaleHospitalizationHumansKaplan-Meier EstimateLogistic ModelsMaleMiddle AgedMultivariate AnalysisOdds RatioPatient SelectionPennsylvaniaPropensity ScoreProportional Hazards ModelsRenal DialysisRisk AssessmentRisk FactorsSeverity of Illness IndexTime FactorsTreatment OutcomeConceptsInitiation of dialysisSerum creatinine concentrationCreatinine concentrationDialysis initiationDialyzed patientsSevere AKICohort studyPropensity-matched cohort studyPropensity scoreElevated creatinine levelOverall hazard ratioGreater survival benefitProportional hazards analysisAcute care hospitalsTime-varying propensity scoresPennsylvania Health SystemCause mortalityCreatinine levelsHazard ratioSurvival benefitCare hospitalDL increaseNondialyzed patientsPatient factorsLaboratory variables