2023
Hypertension, Blood Pressure Variability, and Acute Kidney Injury in Hospitalized Children
Nugent J, Ghazi L, Yamamoto Y, Bakhoum C, Wilson F, Greenberg J. Hypertension, Blood Pressure Variability, and Acute Kidney Injury in Hospitalized Children. Journal Of The American Heart Association 2023, 12: e029059. PMID: 37119062, PMCID: PMC10227226, DOI: 10.1161/jaha.122.029059.Peer-Reviewed Original ResearchConceptsAcute kidney injuryBlood pressure variabilityBlood pressure measurementsHospitalized childrenKidney injuryBlood pressurePressure variabilityIncident acute kidney injuryTime-updated Cox modelsMean blood pressureEnd-organ complicationsAnalysis of hypertensionAKI riskConclusions HypertensionHypertension thresholdInpatient hypertensionNormotensive patientsOrgan complicationsNonpharmacologic interventionsRetrospective cohortPediatric inpatientsMultivariable modelPediatric encountersHypertensionCox model
2022
Urine Uromodulin as a Biomarker of Kidney Tubulointerstitial Fibrosis
Melchinger H, Calderon-Gutierrez F, Obeid W, Xu L, Shaw MM, Luciano RL, Kuperman M, Moeckel GW, Kashgarian M, Wilson FP, Parikh CR, Moledina DG. Urine Uromodulin as a Biomarker of Kidney Tubulointerstitial Fibrosis. Clinical Journal Of The American Society Of Nephrology 2022, 17: 1284-1292. PMID: 35948365, PMCID: PMC9625093, DOI: 10.2215/cjn.04360422.Peer-Reviewed Original ResearchConceptsInterstitial fibrosis/tubular atrophyUrine uromodulinTubular atrophyThick ascending limbUrine albuminSerum creatinineKidney biopsyTubulointerstitial fibrosisMultivariable linear regression modelsTime of biopsyKidney's thick ascending limbAcademic medical centerHuman kidney biopsiesKidney tubulointerstitial fibrosisTubular healthMultivariable analysisHistologic featuresHistologic findingsHistologic changesKidney fibrosisIndependent associationFibrotic modelMultivariable modelMedical CenterMurine modelUrine testing to differentiate glomerular from tubulointerstitial diseases on kidney biopsy
Tran AC, Melchinger H, Weinstein J, Shaw M, Kent C, Perazella MA, Wilson FP, Parikh CR, Moledina DG. Urine testing to differentiate glomerular from tubulointerstitial diseases on kidney biopsy. Practical Laboratory Medicine 2022, 30: e00271. PMID: 35465621, PMCID: PMC9018443, DOI: 10.1016/j.plabm.2022.e00271.Peer-Reviewed Original ResearchTubulointerstitial diseaseKidney biopsyGlomerular diseaseUrine albuminHistological diagnosisUrine uromodulinUrine testsHigher urine albuminUrine sediment microscopyCohort of participantsDipstick hematuriaTubular injuryAppropriate patientsUrine testingMultivariable modelHigher oddsBiopsyClinical decisionSediment microscopyDiseasePatientsHealth biomarkersUrine samplesDiagnosisCohortExcessive Blood Pressure Response to Clonidine in Hospitalized Patients With Asymptomatic Severe Hypertension
Hanna J, Ghazi L, Yamamoto Y, Simonov M, Shah T, Wilson F, Peixoto A. Excessive Blood Pressure Response to Clonidine in Hospitalized Patients With Asymptomatic Severe Hypertension. American Journal Of Hypertension 2022, 35: 433-440. PMID: 35038322, PMCID: PMC9088839, DOI: 10.1093/ajh/hpac004.Peer-Reviewed Original ResearchConceptsAsymptomatic severe hypertensionBlood pressure responseSevere hypertensionHospitalized patientsPressure responseExcessive blood pressure responseMean arterial pressure reductionMAP reductionAcute kidney injuryBlood pressure declineArterial pressure reductionHours of administrationClonidine doseKidney injuryPrimary endpointAdverse eventsIschemic eventsBlood pressureIll patientsClinical groundsMedian timePatient sexFemale sexVascular diseaseMultivariable model