2017
Dried plum alleviates symptoms of inflammatory arthritis in TNF transgenic mice
Mirza F, Lorenzo J, Drissi H, Lee FY, Soung DY. Dried plum alleviates symptoms of inflammatory arthritis in TNF transgenic mice. The Journal Of Nutritional Biochemistry 2017, 52: 54-61. PMID: 29149648, DOI: 10.1016/j.jnutbio.2017.10.002.Peer-Reviewed Original ResearchConceptsTumor necrosis factorTransgenic miceRheumatoid arthritisNuclear factor-kappa B activationDP dietBone-preserving propertiesReduction of synovitisPresence of TNFFour-week treatmentOnset of arthritisResistant acid phosphatase-positive cellsAcid phosphatase-positive cellsDestruction of jointsHuman synovial fibroblastsTNF-transgenic miceHuman tumor necrosis factorKappa B activationActivated T cellsFormation of osteoclastsMouse bone marrow macrophagesBone marrow macrophagesArticular cartilagePostmenopausal womenInflammatory arthritisBone erosionWhole grape alleviates inflammatory arthritis through inhibition of tumor necrosis factor
Stamer D, Nizami S, Lee F, Do Y. Soung. Whole grape alleviates inflammatory arthritis through inhibition of tumor necrosis factor. Journal Of Functional Foods 2017, 35: 458-465. DOI: 10.1016/j.jff.2017.06.018.Peer-Reviewed Original ResearchTumor necrosis factorTransgenic miceRheumatoid arthritisTg miceNecrosis factorMacrophage inflammatory protein-1 alphaInflammatory protein-1 alphaAnti-rheumatic efficacySynovitis/enthesitisGP dietProtein-1 alphaHuman tumor necrosis factorRA symptomsInflammatory arthritisRegular dietBone massOsteoclastogenic factorsPowder dietMatrix metalloproteinasesMiceArthritisDietArticular cartilageWhole grapesGPs
2012
Modern Interpretation of Giant Cell Tumor of Bone: Predominantly Osteoclastogenic Stromal Tumor
Kim Y, Nizami S, Goto H, Lee FY. Modern Interpretation of Giant Cell Tumor of Bone: Predominantly Osteoclastogenic Stromal Tumor. Clinics In Orthopedic Surgery 2012, 4: 107-116. PMID: 22662295, PMCID: PMC3360182, DOI: 10.4055/cios.2012.4.2.107.Peer-Reviewed Original ResearchConceptsGiant cell tumorStromal cell-derived factor-1Tumor necrosis factorCell tumorsBone destructionNuclear factor kappa-B ligandCell-derived factor-1Stromal cell tumorsPro-osteoclastogenic cytokinesGCT treatmentAdjuvant therapySurgical excisionStromal tumorsTumor comprisingInflammatory cytokinesChemoattractant proteinNecrosis factorParacrine loopExcessive osteoclastogenesisReceptor activatorOrthopaedic surgeonsOsteoclast precursorsOsteoclastic cellsMesenchymal originTumors
2007
Orthopedic Implant Particle‐Induced Tumor Necrosis Factor‐α Production in Macrophage–Monocyte Lineage Cells Is Mediated by Nuclear Factor of Activated T Cells
MINEMATSU H, SHIN MJ, AYDEMIR A, SEO SW, KIM DW, BLAINE TA, MACIÁN F, YANG J, LEE F. Orthopedic Implant Particle‐Induced Tumor Necrosis Factor‐α Production in Macrophage–Monocyte Lineage Cells Is Mediated by Nuclear Factor of Activated T Cells. Annals Of The New York Academy Of Sciences 2007, 1117: 143-150. PMID: 18056040, DOI: 10.1196/annals.1402.026.Peer-Reviewed Original ResearchConceptsActivated T cellsT cellsLineage cellsTumor Necrosis Factor-α ProductionNuclear factorMonocyte-macrophage lineage cellsTNF-alpha protein secretionTNF-alpha expressionTNF-alpha productionTNF-alpha gene expressionTumor necrosis factorMurine macrophage-like RAW264.7Macrophage-like RAW264.7TNF-alpha inductionMonocyte-macrophage cellsTNF-alphaNecrosis factorSpecific molecular mechanismsImplant particlesJoint prosthesesMolecular mechanisms